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Review: could Tramadol cause Depression?

Summary: Depression is found among people who take Tramadol, especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years, also take medication Tramadol hcl, and have Pain. We study 38,732 people who have side effects while taking Tramadol from FDA and social media. Among them, 1,244 have Depression. Find out below who they are, when they have Depression and more.

You are not alone: join a support group for people who take Tramadol and have Depression >>>

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>

 

Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from 41,598 Tramadol users)

Depression

Depression has been reported by people with quit smoking, multiple sclerosis, pain, osteoporosis, acne. (latest reports from 277,750 Depression patients)

On May, 2, 2015: 38,732 people reported to have side effects when taking Tramadol. Among them, 1,244 people (3.21%) have Depression.

Trend of Depression in Tramadol reports

Time on Tramadol when people have Depression * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Depression17.13%14.92%7.18%9.39%37.57%9.94%3.87%

Gender of people who have Depression when taking Tramadol * :

FemaleMale
Depression70.44%29.56%

Age of people who have Depression when taking Tramadol * :

0-12-910-1920-2930-3940-4950-5960+
Depression0.00%0.00%2.19%5.66%18.63%23.38%27.85%22.28%

Severity of Depression when taking Tramadol ** :

leastmoderateseveremost severe
Depression9.76%36.59%34.15%19.51%

How people recovered from Depression ** :

while on the drugafter off the drugnot yet
Depression7.41%22.22%70.37%

Top conditions involved for these people * :

  1. Pain (275 people, 22.11%)
  2. Depression (254 people, 20.42%)
  3. Anxiety (159 people, 12.78%)
  4. Smoking cessation therapy (148 people, 11.90%)
  5. Hypertension (74 people, 5.95%)

Top co-used drugs for these people * :

  1. Tramadol hcl (832 people, 66.88%)
  2. Aspirin (196 people, 15.76%)
  3. Omeprazole (183 people, 14.71%)
  4. Lorazepam (170 people, 13.67%)
  5. Neurontin (162 people, 13.02%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of tramadol and depression on

Do you have Depression while taking Tramadol?

 

You are not alone! Join a support group on :
- support group for people who take Tramadol and have Depression
- support group for people who take Tramadol
- support group for people who have Depression

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More questions for: Tramadol, Depression

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More reviews for: Tramadol, Depression

Comments from related studies:

  • From this study (8 months ago):

  • Low testosterone in the low 100s

    Reply

  • From this study (8 months ago):

  • Help

    Reply

  • From this study (9 months ago):

  • I started losing my hair more when I started taking the tramadol for pain. I have lost quite a bit of hair since then and started balding on the top of my head. I don't know if it is hormonal or from all the medication I am on because I know that can cause hair loss also. My hair is also limp and lifeless and I have gained about 15 pounds since being on the tramadol. It is the only medication that helps with my pain and chronic anxiety caused by the Cymbalta so I don't know what else to do.

    Reply

    axeman225 on Sep, 17, 2014:

    Hi! I am a 26yr old male. I saw this and seems like we are taking the same meds and I wanted to compare. I have been on tramadol for almost 3 years for herniated discs from playing football. I recently have noticed and heard that long term use affects testosterone levels, so I got bloodwork done...turns out I am below range on all levels...which sucks because I am fit (or was) and pretty big. So my doc prescribed testim 1% 50mg/day (as of yesterday) and I wanted to see how it affected you along with takign the tramadol. I dont have hair issues, but I have had weight gain and general feminization due to loss of testosterone....so gross and sad for me. Idk if you are male or female...but I would love to hear what the combo has done for you. If anyone else can chime in it would be great. (fyi..tramadol is a low dose opiate agonist for pain; testim is testosterone gel)

    Reply

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