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Review: could Tramadol cause Heartburn (Gastroesophageal reflux disease)?

We study 38,575 people who have side effects while taking Tramadol from FDA and social media. Among them, 36 have Heartburn. Find out below who they are, when they have Heartburn and more.

Get connected: join a mobile support group for people who take Tramadol and have Heartburn >>>


Tramadol (latest outcomes from 41,430 users) has active ingredients of tramadol hydrochloride. It is often used in pain.


Heartburn (a condition in which stomach contents leak backward from the stomach into the oesophagus) (latest reports from 46,017 patients) has been reported by people with high blood pressure, depression, osteoporosis, high blood cholesterol, pain.

On Sep, 13, 2014: 38,575 people reported to have side effects when taking Tramadol. Among them, 36 people (0.09%) have Heartburn.

Trend of Heartburn in Tramadol reports

Time on Tramadol when people have Heartburn * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Heartburn when taking Tramadol * :


Age of people who have Heartburn when taking Tramadol * :


Severity of Heartburn when taking Tramadol ** :

leastmoderateseveremost severe

How people recovered from Heartburn ** :

while on the drugafter off the drugnot yet

Top conditions involved for these people * :

  1. Pain (7 people, 19.44%)
  2. Asthma (5 people, 13.89%)
  3. Nausea (3 people, 8.33%)
  4. Back pain (3 people, 8.33%)
  5. Glossitis (2 people, 5.56%)

Top co-used drugs for these people * :

  1. Tramadol hcl (17 people, 47.22%)
  2. Celebrex (7 people, 19.44%)
  3. Ibuprofen (6 people, 16.67%)
  4. Lisinopril (6 people, 16.67%)
  5. Omeprazole (6 people, 16.67%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Heartburn while taking Tramadol?

Get connected! Join a mobile support group:
- support group for people who take Tramadol and have Heartburn
- support group for people who take Tramadol
- support group for people who have Heartburn

Comments from related studies:

  • From this study (5 months ago):

  • phyllis on May, 24, 2014:

    How can you determine what is causing the GERD? You are on a medley of pain killers and now sleeping medication (doesn't matter whether it's script or over the counter. I take many medications for fibromyalgia, rheumatoid arthritis, depression and anxiety. However ONE for pain, one for depression, one for anxiety - not a garrison of drugs!! Sounds like the next doctor you need to see is a psych doctor and/or a therapist. The therapist can help you learn how to control pain without using a boatload of drugs!
    Make some changes now or you will be totally addicted to the pain and sleeping pills and no amount will relieve the pain and the sleeping problems.


    Christa on Oct, 20, 2012:

    Wow, was I glad to see this. 27 doesnt seem like a lot - but when you are one of them ... 40 y/o female - coughing was primary symptom when went to ENT - was given Tramadol as rx to help suppress cough ... stopped coughing a while but seemed more related to weather changes which is the norm for me ... but kept taking rx - a month in and now having pretty uncomfortable acid reflux symptoms and even some asthma like stuff going on - weird. Quitting the stuff tonite.


    Tom on Jan, 7, 2013:

    I'm a male, 58 years old. Have been taking Tramadol for 3-4 years, currently using (3) 50mg tabs in the evening, one between 5:00-7:00,one at 9:00 & one around 1:00 A.M. Also, take (2)Vicodin(7.5/325) at night, Gabapentin (2)(300mg) capsules at night, flexeril (1)(10mg) and was using ibuprofen when needed. This is all for lower back pain that only bothers me at night. Even applying DMSO & Ben Gay topically when the pills don't quite take away the pain. I let the DMSO soak in for 20-30 minutes and the put Ben Gay on top of it. I spent many years lifting heavy weights and wore the cartilage down in my back and other joints. One year ago I woke up at 4:00 A.M. with "fluttering" feeling behind my sternum. Went to the emergency, heart was fine. Idiot doctors diagnosed it as anxiety. Same thing happened the next night. Same diagnosis. First of all, don't most people going to the emergency have some level of anxiety? After going to my GP he diagnosed it as GERD. Why don't emergency room doctors and nurses know all the symptoms of GERD, such as palpitations behind the sternum where you heart & esophagus are located. Cost me two emergency visits with no insurance. IDIOTS!! I was taking (6) Tramadol a year ago, now down to 2 1/2 to 3 nightly. I think the Tramadol causes insomnia also, I use over the counter sleeping pills & melatonin & valerian to help me sleep. I'm now looking into everything that I take to determine which might cause GERD.


  • From this study (7 months ago):

  • Suspicion that general muscle pain is caused by meds. Both Tylenol and Tramadol are taken TID to QID rather than PRN.


Post a new comment    OR    Read more comments

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used for pain. Find out below the conditions Tramadol is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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