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Review: could Tramadol cause Leg pain?

Summary: Leg pain could be caused by Tramadol, especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years, also take Tramadol hydrochloride, and have Gerd.

We study 38,402 people who have side effects while taking Tramadol from FDA and social media. Among them, 7 have Leg pain. Find out below who they are, when they have Leg pain and more.

On Apr, 16, 2014: 38,402 people reported to have side effects when taking Tramadol. Among them, 7 people (0.02%) have Leg Pain. They amount to 0.34% of all the 2,070 people who have Leg Pain on eHealthMe.

Trend of Leg pain in Tramadol reports

Time on Tramadol when people have Leg pain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Leg pain0.00%28.57%0.00%42.86%14.29%14.29%0.00%

Gender of people who have Leg pain when taking Tramadol * :

Leg pain85.71%14.29%

Age of people who have Leg pain when taking Tramadol * :

Leg pain0.00%0.00%0.00%0.00%0.00%0.00%42.86%57.14%

Severity of Leg pain when taking Tramadol ** :

leastmoderateseveremost severe
Leg pain0.00%14.29%57.14%28.57%

How people recovered from Leg pain ** :

while on the drugafter off the drugnot yet
Leg pain0.00%25.00%75.00%

Top conditions involved for these people * :

  1. Gerd (2 people, 28.57%)
  2. Pain (2 people, 28.57%)
  3. Anemia (2 people, 28.57%)
  4. Pernicious anaemia (1 people, 14.29%)
  5. Depression (1 people, 14.29%)

Top co-used drugs for these people * :

  1. Tramadol hydrochloride (4 people, 57.14%)
  2. Vitamin d (2 people, 28.57%)
  3. Furosemide (2 people, 28.57%)
  4. Omeprazole (2 people, 28.57%)
  5. Gabapentin (2 people, 28.57%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Tramadol, Leg pain

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used for pain. Find out below the conditions Tramadol is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Tramadol used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (6 months ago):

  • I had spinal fusion and bone graft two years ago for broken lower back and also had a tumor on top of the nerve on top of the break. Since that time the pain has never gone away and I do suffer back spasms. The strange thing is I really have gastric problems now (I do know that dairy products are a no-no - this is pretty severe and I am probably sick about 75% of the time.) Now I increasing have a pain in my left leg that is getting more and more constant and painful.


  • From this study (12 months ago):

  • I have had leg cramps during the night for a number of years. I started taking Gabapentin January 2013 1 capsule evening then increased to 1 capsule in the morning and one at night. March 28, 2013, reduced to 1 capsule at night for one week and then discontinued. Since then I have had severe leg cramps at night. Sometimes waking up every hour all night long. The pharmacist said that I stopped the medication too soon. During that time I had problems with phlegm. I started taking Allegra. The leg cramps continued and I thought it was the Allegra, so I stopped taking that. I have always had low potassium and I had a blood sample taken today. I will have the results tomorrow, but wondered if any of these medications could cause the leg cramps. They are really very severe. I drink water during the day and have been eating a banana every day for the potassium.


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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