Tramadol and Serotonin syndrome - from FDA reports


Summary

Serotonin syndrome is found among people who take Tramadol, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Mirtazapine, and have Depression. This review analyzes which people have Serotonin syndrome with Tramadol. It is created by eHealthMe based on reports of 79,416 people who have side effects when taking Tramadol from FDA, and is updated regularly.

What to expect?

If you take Tramadol and have Serotonin syndrome, find out what symptoms you could have in 1 year or longer.

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On May, 14, 2017

79,416 people reported to have side effects when taking Tramadol.
Among them, 1,024 people (1.29%) have Serotonin Syndrome


Number of reports submitted per year:

Could Tramadol cause Serotonin syndrome?

Time on Tramadol when people have Serotonin Syndrome *:

  • < 1 month: 59.67 %
  • 1 - 6 months: 15.47 %
  • 6 - 12 months: 4.42 %
  • 1 - 2 years: 2.21 %
  • 2 - 5 years: 18.23 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Serotonin Syndrome when taking Tramadol *:

  • female: 64.74 %
  • male: 35.26 %

Age of people who have Serotonin Syndrome when taking Tramadol *:

  • 0-1: 0.12 %
  • 2-9: 0.0 %
  • 10-19: 1.39 %
  • 20-29: 9.82 %
  • 30-39: 18.01 %
  • 40-49: 16.86 %
  • 50-59: 18.59 %
  • 60+: 35.22 %

Top conditions involved for these people *:

  • Depression (299 people, 29.20%)
  • Pain (241 people, 23.54%)
  • Analgesic Therapy (79 people, 7.71%)
  • Back Pain (74 people, 7.23%)
  • Neck Pain (50 people, 4.88%)

Top co-used drugs for these people *:

  • Mirtazapine (116 people, 11.33%)
  • Diazepam (105 people, 10.25%)
  • Omeprazole (73 people, 7.13%)
  • Cymbalta (73 people, 7.13%)
  • Lorazepam (68 people, 6.64%)

Top other side effects for these people *:

  • Hyperhidrosis (159 people, 15.53%)
  • Arrhythmias (156 people, 15.23%)
  • Tremor (149 people, 14.55%)
  • Agitation (145 people, 14.16%)
  • Fever (132 people, 12.89%)

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Serotonin syndrome when taking Tramadol?

Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 84,575 users)

Serotonin Syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) has been reported by people with depression, pain, stress and anxiety, major depression, insomnia (latest reports from 10,171 Serotonin syndrome patients).

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What would happen?

Forecast new side effects and undetected conditions when you take Tramadol and have Serotonin syndrome.

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