Review: could Tramadol cause Serotonin Syndrome?


Serotonin syndrome is found among people who take Tramadol, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Citalopram, and have Depression . We study 15,018 people who have side effects while taking Tramadol from FDA and social media. Among them, 108 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

You are not alone

Join a support group for people who take Tramadol and have Serotonin syndrome >>>

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 49,036 users)

Serotonin Syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) has been reported by people with disease complication, insomnia, feeling jittery, vaginal discharge, bruxism (latest reports from 7,451 Serotonin syndrome patients).

On Aug, 24, 2016

15,018 people reported to have side effects when taking Tramadol.
Among them, 108 people (0.72%) have Serotonin Syndrome

Number of reports submitted per year:

Could Tramadol cause Serotonin syndrome?

Time on Tramadol when people have Serotonin Syndrome *:

  • < 1 month: 33.33 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 11.11 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 18.52 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 3.7 %

Gender of people who have Serotonin Syndrome when taking Tramadol *:

  • female: 51.46 %
  • male: 48.54 %

Age of people who have Serotonin Syndrome when taking Tramadol *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 1.05 %
  • 20-29: 7.37 %
  • 30-39: 11.58 %
  • 40-49: 17.89 %
  • 50-59: 22.11 %
  • 60+: 40.0 %

Severity if Serotonin Syndrome when taking Tramadol **:

  • least: 0.0 %
  • moderate: 100 %
  • severe: 0.0 %
  • most severe: 0.0 %

How people recovered from Serotonin Syndrome **:

  • while on drug: 0.0 %
  • after off the drug: 50 %
  • not yet: 50 %

Top conditions involved for these people *:

  • Depression (40 people)
  • Pain (23 people)
  • Analgesic Therapy (19 people)
  • Psychotic Disorder (10 people)
  • Neuralgia (9 people)

Top co-used drugs for these people *:

  • Citalopram (23 people)
  • Omeprazole (17 people)
  • Amitriptyline (17 people)
  • Gabapentin (16 people)
  • Lorazepam (12 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Serotonin syndrome when taking Tramadol?

Browse all side effects of Tramadol

a b c d e f g h i j k l m n o p q r s t u v w x y z

Drugs that are associated with Serotonin syndrome

Serotonin syndrome

Could your condition cause Serotonin syndrome

Serotonin syndrome

Can you answer these questions?

More questions for: Tramadol, Serotonin syndrome

You may be interested in these reviews

More reviews for: Tramadol, Serotonin syndrome

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.