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Review: could Tramadol cause Serotonin syndrome?

Summary: Serotonin syndrome could be caused by Tramadol, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Tramadol hcl, and have Depression.

We study 38,402 people who have side effects while taking Tramadol from FDA and social media. Among them, 549 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

On Apr, 7, 2014: 38,376 people reported to have side effects when taking Tramadol. Among them, 549 people (1.43%) have Serotonin Syndrome. They amount to 1.60% of all the 34,351 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Tramadol reports

Time on Tramadol when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome53.66%10.57%3.25%3.25%28.46%0.81%0.00%

Gender of people who have Serotonin syndrome when taking Tramadol * :

FemaleMale
Serotonin syndrome73.46%26.54%

Age of people who have Serotonin syndrome when taking Tramadol * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.19%0.00%0.75%8.26%24.58%20.45%16.89%28.89%

Severity of Serotonin syndrome when taking Tramadol ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%33.33%33.33%33.33%

How people recovered from Serotonin syndrome ** :

while on the drugafter off the drugnot yet
Serotonin syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (183 people, 33.33%)
  2. Pain (97 people, 17.67%)
  3. Neck pain (50 people, 9.11%)
  4. Back pain (49 people, 8.93%)
  5. Psychotic disorder (41 people, 7.47%)

Top co-used drugs for these people * :

  1. Tramadol hcl (453 people, 82.51%)
  2. Mirtazapine (120 people, 21.86%)
  3. Diazepam (112 people, 20.40%)
  4. Tramadol hydrochloride (99 people, 18.03%)
  5. Paroxetine hcl (81 people, 14.75%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Tramadol, Serotonin syndrome

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used for pain. Find out below the conditions Tramadol is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Tramadol used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (13 months ago):

  • Dr. thinking I may have an issue with serotonin carcinoid/syndrome-bad reaction to prednisone therapy this time? stomach acid, then crazy flashing of skin/hive like? with and without sweating, agitation, rapid heart beat, high blood pressure-150/85, and running temp 101.5
    just seen, took me off tramadol, (which I have taken for years), added hydroxyzine, and is having me do 5-HIAA. Question is what caused all this? Never had an issue before now with prednisone or tramadol?
    Is it possible that the prednisone caused this?

    Reply

  • From this study (2 years ago):

  • Have had several episodes of seratonin syndrome with mild to moderate symptoms. Reglan causes severe muscle spasms in the jaw.

    Reply

  • From this study (3 years ago):

  • After finding that the Humira made me nauseous I started to use Medical Marijuana for the nausea. It seems to get rid of nausea for a couple of hours but still came back.

    Reply

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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