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Review: could Tramadol cause Serotonin syndrome?

Summary: Serotonin syndrome is found among people who take Tramadol, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Tramadol hcl, and have Depression.

We study 38,699 people who have side effects while taking Tramadol from FDA and social media. Among them, 550 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

You are not alone: join a mobile support group for people who take Tramadol and have Serotonin syndrome >>>

 

 

 

 

Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from 41,556 Tramadol users)

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder. (latest reports from 6,558 Serotonin syndrome patients)

On Feb, 24, 2015: 38,682 people reported to have side effects when taking Tramadol. Among them, 550 people (1.42%) have Serotonin Syndrome.

Trend of Serotonin syndrome in Tramadol reports

Time on Tramadol when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome54.03%10.48%3.23%3.23%28.23%0.81%0.00%

Gender of people who have Serotonin syndrome when taking Tramadol * :

FemaleMale
Serotonin syndrome73.33%26.67%

Age of people who have Serotonin syndrome when taking Tramadol * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.19%0.00%0.75%8.24%24.53%20.60%16.85%28.84%

Severity of Serotonin syndrome when taking Tramadol ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%50.00%25.00%25.00%

How people recovered from Serotonin syndrome ** :

while on the drugafter off the drugnot yet
Serotonin syndrome0.00%33.33%66.67%

Top conditions involved for these people * :

  1. Depression (183 people, 33.27%)
  2. Pain (97 people, 17.64%)
  3. Neck pain (50 people, 9.09%)
  4. Back pain (49 people, 8.91%)
  5. Psychotic disorder (41 people, 7.45%)

Top co-used drugs for these people * :

  1. Tramadol hcl (453 people, 82.36%)
  2. Mirtazapine (120 people, 21.82%)
  3. Diazepam (112 people, 20.36%)
  4. Tramadol hydrochloride (99 people, 18.00%)
  5. Paroxetine hcl (81 people, 14.73%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of tramadol and serotonin syndrome on

Do you have Serotonin Syndrome while taking Tramadol?

You are not alone! Join a mobile support group:
- support group for people who take Tramadol and have Serotonin Syndrome
- support group for people who take Tramadol
- support group for people who have Serotonin Syndrome

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More questions for: Tramadol, Serotonin syndrome

You may be interested at these reviews (Write a review):

  • Roaring in the ears from tramadol (taken with dexamethasone)
    It seems the roaring in my right ear happens more around taking the tramadol (2-3/day). Of course, I have a (5) day regiment of dexamethasone at (2/day) so maybe there's a connection. This was prescribed by my GP ( highly regarded) for severe lower back bulging disc pain and down left leg. Also prescribed tizanidine for muscle spasms and gabapentin for, maybe nerve swelling? Both at 2/day but I take less of these two.

    Back pain much better but have the roaring in right ear and can't sleep much. Also doing the Dr recommended exercises daily. Will follow up with chiropractic if this doesn't get me there.

    This is a chronic condition, maybe 20 years, no specific injury, just an accumulation of doing dumb things in my youth.
  • Tramadol and severe rls and restless arms
    After back surgery I was prescribed Tramadol for pain. After about a month I developed severe RLS and also restless arms that seemed to make it hard to breath. Like a weight on my chest. I noticed that after taking the Tramadol, only at night for sleep, the restless symptoms got worse for about an hour and then settled down some. Before long there was no settling down. My pain after several months being better in my back I, not liking to take medicine period, decided to stop the Tramadol. To my surprise my RLS came to almost a complete halt. After about a week it was gone completely.
  • Mom died of stomach blockage while on tramadol
    my mom was taking tramadol for hip pain. she went in the hospital for a hip replacement and died 3 days after the surgery in the hospital from an intestinal blockage
  • Using tramadol with anti-depressants
    Using Tramadol with Anti-depressants

    I was taking Tramadol for pain instead of Endone to cut out the opiates as well as my usual anti-depressant. After about 6 months of feeling dizzy spells and nausea I stumbled across information that these two medications should not be mixed. After all of the extensive tests they did to find out why I had these symptoms, I informed my Doctor of what I had discovered. Much the their embarrassment, they realised I was correct and immediately took me off the tramadol. I just thought I would share this information in case any one else is going through what I did.
  • No noticeable effects
    No noticeable effects when used together. Tramadol dose 50-100 mg's four times a day.

More reviews for: Tramadol, Serotonin syndrome

Comments from related studies:

  • From this study (4 months ago):

  • elevated heart rate and palpitation, using Colona pin to relax and slow heart beat not working

    Reply

  • From this study (2 years ago):

  • Dr. thinking I may have an issue with serotonin carcinoid/syndrome-bad reaction to prednisone therapy this time? stomach acid, then crazy flashing of skin/hive like? with and without sweating, agitation, rapid heart beat, high blood pressure-150/85, and running temp 101.5
    just seen, took me off tramadol, (which I have taken for years), added hydroxyzine, and is having me do 5-HIAA. Question is what caused all this? Never had an issue before now with prednisone or tramadol?
    Is it possible that the prednisone caused this?

    Reply

  • From this study (3 years ago):

  • Have had several episodes of seratonin syndrome with mild to moderate symptoms. Reglan causes severe muscle spasms in the jaw.

    Reply

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