Tramadol and Serotonin syndrome - from FDA reports


Summary

Serotonin syndrome is found among people who take Tramadol, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Mirtazapine, and have Depression. This review analyzes which people have Serotonin syndrome with Tramadol. It is created by eHealthMe based on reports of 83,165 people who have side effects when taking Tramadol from FDA , and is updated regularly.

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On Oct, 23, 2017

83,165 people reported to have side effects when taking Tramadol.
Among them, 1,052 people (1.26%) have Serotonin syndrome


Number of reports submitted per year:

Could Tramadol cause Serotonin syndrome?

Time on Tramadol when people have Serotonin syndrome *:

  • < 1 month: 61.17 %
  • 1 - 6 months: 14.36 %
  • 6 - 12 months: 4.79 %
  • 1 - 2 years: 2.13 %
  • 2 - 5 years: 17.55 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Serotonin syndrome when taking Tramadol *:

  • female: 65.13 %
  • male: 34.87 %

Age of people who have Serotonin syndrome when taking Tramadol *:

  • 0-1: 0.11 %
  • 2-9: 0.0 %
  • 10-19: 1.57 %
  • 20-29: 10.21 %
  • 30-39: 17.73 %
  • 40-49: 16.39 %
  • 50-59: 18.74 %
  • 60+: 35.24 %

Top conditions involved for these people *:

  • Depression (304 people, 28.90%)
  • Analgesic Therapy (80 people, 7.60%)
  • Back Pain (76 people, 7.22%)
  • Neck Pain (51 people, 4.85%)
  • Psychotic Disorder (42 people, 3.99%)

Top co-used drugs for these people *:

  • Mirtazapine (116 people, 11.03%)
  • Diazepam (105 people, 9.98%)
  • Cymbalta (74 people, 7.03%)
  • Omeprazole (73 people, 6.94%)
  • Lorazepam (68 people, 6.46%)

Top other side effects for these people *:

  • Hyperhidrosis (159 people, 15.11%)
  • Tremor (150 people, 14.26%)
  • Agitation (145 people, 13.78%)
  • Arrhythmias (144 people, 13.69%)
  • Fever (134 people, 12.74%)

* Approximation only. Some reports may have incomplete information.

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Serotonin syndrome and Tramadol from FDA and eHealthMe reports

Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 88,458 users)

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) has been reported by people with depression, pain, stress and anxiety, major depression, insomnia (latest reports from 10,388 Serotonin syndrome patients).

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