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Review: could Tramadol cause Stomach upset (Nausea and vomiting)?

Summary: Stomach upset is found among people who take Tramadol, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Tramadol hcl, and have Pain.

We study 38,712 people who have side effects while taking Tramadol from FDA and social media. Among them, 2,194 have Stomach upset. Find out below who they are, when they have Stomach upset and more.

You are not alone: join a support group for people who take Tramadol and have Stomach upset >>>



Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from 41,576 Tramadol users)

Stomach upset

Stomach upset has been reported by people with high blood pressure, pain, depression, multiple sclerosis, rheumatoid arthritis. (latest reports from 142,488 Stomach upset patients)

On Mar, 28, 2015: 38,712 people reported to have side effects when taking Tramadol. Among them, 1,980 people (5.11%) have Stomach Upset.

Trend of Stomach upset in Tramadol reports

Time on Tramadol when people have Stomach upset * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Stomach upset66.89%12.25%4.30%3.31%12.58%0.66%0.00%

Gender of people who have Stomach upset when taking Tramadol * :

Stomach upset69.70%30.30%

Age of people who have Stomach upset when taking Tramadol * :

Stomach upset0.11%0.00%2.89%7.46%11.92%15.57%19.16%42.90%

Severity of Stomach upset when taking Tramadol ** :

leastmoderateseveremost severe
Stomach upset3.03%51.52%42.42%3.03%

How people recovered from Stomach upset ** :

while on the drugafter off the drugnot yet
Stomach upset15.38%30.77%53.85%

Top conditions involved for these people * :

  1. Pain (397 people, 20.05%)
  2. Depression (161 people, 8.13%)
  3. Hypertension (137 people, 6.92%)
  4. Rheumatoid arthritis (126 people, 6.36%)
  5. Back pain (113 people, 5.71%)

Top co-used drugs for these people * :

  1. Tramadol hcl (1,574 people, 79.49%)
  2. Aspirin (336 people, 16.97%)
  3. Omeprazole (260 people, 13.13%)
  4. Tramadol hydrochloride (240 people, 12.12%)
  5. Acetaminophen (220 people, 11.11%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of tramadol and stomach upset on

Do you have Stomach Upset while taking Tramadol?




You are not alone! Join a support group on :
- support group for people who take Tramadol and have Stomach Upset
- support group for people who take Tramadol
- support group for people who have Stomach Upset

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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