Tysabri and Progressive multifocal leukoencephalopathy - from FDA reports


Summary

Progressive multifocal leukoencephalopathy is found among people who take Tysabri, especially for people who are female, 40-49 old , have been taking the drug for 2 - 5 years, also take medication Baclofen, and have Multiple sclerosis . We study 160,334 people who have side effects while taking Tysabri from FDA. Among them, 4,000 have Progressive multifocal leukoencephalopathy. Find out below who they are, when they have Progressive multifocal leukoencephalopathy and more.

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Tysabri

Tysabri has active ingredients of natalizumab. It is often used in multiple sclerosis. (latest outcomes from Tysabri 160,733 users)

Progressive Multifocal Leukoencephalopathy

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells) has been reported by people with multiple sclerosis, relapsing-remitting multiple sclerosis, chronic lymphocytic leukaemia, non-hodgkin's lymphoma, rheumatoid arthritis (latest reports from 7,273 Progressive multifocal leukoencephalopathy patients).

On Jan, 21, 2017

160,334 people reported to have side effects when taking Tysabri.
Among them, 4,000 people (2.49%) have Progressive Multifocal Leukoencephalopathy


Number of reports submitted per year:

Could Tysabri cause Progressive multifocal leukoencephalopathy?

Time on Tysabri when people have Progressive Multifocal Leukoencephalopathy *:

  • < 1 month: 1.95 %
  • 1 - 6 months: 2.58 %
  • 6 - 12 months: 3.95 %
  • 1 - 2 years: 15.15 %
  • 2 - 5 years: 65.83 %
  • 5 - 10 years: 10.48 %
  • 10+ years: 0.06 %

Gender of people who have Progressive Multifocal Leukoencephalopathy when taking Tysabri *:

  • female: 68.68 %
  • male: 31.32 %

Age of people who have Progressive Multifocal Leukoencephalopathy when taking Tysabri *:

  • 0-1: 0.06 %
  • 2-9: 0.03 %
  • 10-19: 0.89 %
  • 20-29: 6.01 %
  • 30-39: 24.1 %
  • 40-49: 37.17 %
  • 50-59: 22.24 %
  • 60+: 9.5 %

Top conditions involved for these people *:

  • Multiple Sclerosis (2,892 people, 72.30%)
  • Relapsing-Remitting Multiple Sclerosis (887 people, 22.18%)
  • Depression (216 people, 5.40%)
  • Muscle Spasticity (152 people, 3.80%)
  • Pain (136 people, 3.40%)

Top co-used drugs for these people *:

  • Baclofen (234 people, 5.85%)
  • Lyrica (147 people, 3.67%)
  • Avonex (121 people, 3.02%)
  • Neurontin (107 people, 2.67%)
  • Provigil (89 people, 2.23%)

Top other side effects for these people *:

  • Immune Reconstitution Syndrome (867 people, 21.68%)
  • Multiple Sclerosis Relapse (559 people, 13.98%)
  • Urinary Tract Infection (216 people, 5.40%)
  • Convulsion (188 people, 4.70%)
  • Multiple Sclerosis (176 people, 4.40%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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