Review: could Tysabri cause Progressive multifocal leukoencephalopathy?
Summary: Progressive multifocal leukoencephalopathy is found among people who take Tysabri, especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years, also take medication Baclofen, and have Multiple sclerosis. We study 97,550 people who have side effects while taking Tysabri from FDA and social media. Among them, 2,943 have Progressive multifocal leukoencephalopathy. Find out below who they are, when they have Progressive multifocal leukoencephalopathy and more.
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Tysabri has active ingredients of natalizumab. It is often used in multiple sclerosis. (latest outcomes from 97,690 Tysabri users)
Progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells) has been reported by people with multiple sclerosis, relapsing-remitting multiple sclerosis, chronic lymphocytic leukaemia, rheumatoid arthritis, non-hodgkin's lymphoma. (latest reports from 5,167 Progressive multifocal leukoencephalopathy patients)
On Apr, 26, 2015: 97,549 people reported to have side effects when taking Tysabri. Among them, 2,943 people (3.02%) have Progressive Multifocal Leukoencephalopathy.
Time on Tysabri when people have Progressive multifocal leukoencephalopathy * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Progressive multifocal leukoencephalopathy||2.76%||3.48%||4.88%||15.32%||68.96%||4.56%||0.04% |
Gender of people who have Progressive multifocal leukoencephalopathy when taking Tysabri * :
|Progressive multifocal leukoencephalopathy||68.23%||31.77% |
Age of people who have Progressive multifocal leukoencephalopathy when taking Tysabri * :
|Progressive multifocal leukoencephalopathy||0.00%||0.00%||0.74%||6.41%||23.34%||37.93%||21.97%||9.62% |
Severity of Progressive multifocal leukoencephalopathy when taking Tysabri ** :
|least||moderate||severe||most severe |
|Progressive multifocal leukoencephalopathy||0.00%||0.00%||0.00%||100.00% |
How people recovered from Progressive multifocal leukoencephalopathy ** :
Top conditions involved for these people * :
- Multiple sclerosis (2,186 people, 74.28%)
- Relapsing-remitting multiple sclerosis (638 people, 21.68%)
- Depression (180 people, 6.12%)
- Muscle spasticity (146 people, 4.96%)
- Fatigue (99 people, 3.36%)
Top co-used drugs for these people * :
- Baclofen (213 people, 7.24%)
- Vitamin d (146 people, 4.96%)
- Lyrica (108 people, 3.67%)
- Provigil (103 people, 3.50%)
- Zanaflex (100 people, 3.40%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Get connected: join our support group of tysabri and progressive multifocal leukoencephalopathy on
Do you have Progressive Multifocal Leukoencephalopathy while taking Tysabri?
You are not alone! Join a support group on :
- support group for people who take Tysabri and have Progressive Multifocal Leukoencephalopathy
- support group for people who take Tysabri
- support group for people who have Progressive Multifocal Leukoencephalopathy
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Comments from related studies:
From this study (4 weeks ago):
Diagnosed with MS in 2008, following optical neuropathy. Steroids in hospital, Took Copaxone, good results, just hated daily injections. Switch to Tysabri. Loved it. Main symptoms fatigue, nerve pain.
July 2013 suffered a fall at home, seemingly for no reason. Resulted in fractured left ankle, requiring surgery, Bone healed immediately, ligaments have taken quite a bit longer, still have numbness on foot, below toes, although I can move all toes independently.
I never was told of a correlation between Tysabri and falling. I'm just reading about this here.
From this study (5 months ago):
I do have Relapsing-Remitting MS. Went to doctor the other day I thought the issue in my hips, leg which is occasional in the right hip but pretty constant in the left. It is not painful- but it feels tight- and I have slight problem walking. Also having balance issues. Doctor things the hip is bursitis and not related to the MS. I think it is spasticity.
From this study (5 months ago):
I was on Tysabri for 6 months and ended up with breast cancer 2 months after I stopped taking it. Is there a correlation. I heard if you are Brac 1 or Brac 2 positive Tysbri could be the culprit. If anyone has family members that have had cancer, check if you are BRAC positive. It could save your life or at least a horrible ordeal.
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