Tysabri and Progressive multifocal leukoencephalopathy - from FDA reports


Summary

Progressive multifocal leukoencephalopathy is found among people who take Tysabri, especially for people who are female, 40-49 old , have been taking the drug for 2 - 5 years, also take medication Baclofen, and have Depression. This review analyzes which people have Progressive multifocal leukoencephalopathy with Tysabri. It is created by eHealthMe based on reports of 167,501 people who have side effects when taking Tysabri from FDA , and is updated regularly.

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On Sep, 20, 2017

167,501 people reported to have side effects when taking Tysabri.
Among them, 4,332 people (2.59%) have Progressive multifocal leukoencephalopathy


Number of reports submitted per year:

Could Tysabri cause Progressive multifocal leukoencephalopathy?

Time on Tysabri when people have Progressive multifocal leukoencephalopathy *:

  • < 1 month: 1.74 %
  • 1 - 6 months: 2.41 %
  • 6 - 12 months: 3.85 %
  • 1 - 2 years: 14.84 %
  • 2 - 5 years: 64.31 %
  • 5 - 10 years: 12.74 %
  • 10+ years: 0.11 %

Gender of people who have Progressive multifocal leukoencephalopathy when taking Tysabri *:

  • female: 68.65 %
  • male: 31.35 %

Age of people who have Progressive multifocal leukoencephalopathy when taking Tysabri *:

  • 0-1: 0.05 %
  • 2-9: 0.03 %
  • 10-19: 0.87 %
  • 20-29: 5.94 %
  • 30-39: 24.34 %
  • 40-49: 37.05 %
  • 50-59: 22.43 %
  • 60+: 9.29 %

Top conditions involved for these people *:

  • Depression (228 people, 5.26%)
  • Muscle Spasticity (157 people, 3.62%)
  • Pain (143 people, 3.30%)
  • Fatigue (99 people, 2.29%)
  • High Blood Pressure (75 people, 1.73%)

Top co-used drugs for these people *:

  • Baclofen (234 people, 5.40%)
  • Lyrica (157 people, 3.62%)
  • Avonex (121 people, 2.79%)
  • Neurontin (110 people, 2.54%)
  • Prozac (92 people, 2.12%)

Top other side effects for these people *:

  • Immune Reconstitution Syndrome (867 people, 20.01%)
  • Urinary Tract Infection (221 people, 5.10%)
  • Convulsion (188 people, 4.34%)
  • Depression (168 people, 3.88%)
  • Epilepsy (151 people, 3.49%)

* Approximation only. Some reports may have incomplete information.

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Do you have Progressive multifocal leukoencephalopathy when taking Tysabri?

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Progressive multifocal leukoencephalopathy and Tysabri from FDA and eHealthMe reports

Tysabri

Tysabri has active ingredients of natalizumab. It is often used in multiple sclerosis. (latest outcomes from Tysabri 167,935 users)

Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells) has been reported by people with multiple sclerosis, relapsing-remitting multiple sclerosis, chronic lymphocytic leukaemia, non-hodgkin's lymphoma, rheumatoid arthritis (latest reports from 7,860 Progressive multifocal leukoencephalopathy patients).

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