Valproic acid and Hypothyroidism - from FDA reports


Hypothyroidism is found among people who take Valproic Acid, especially for people who are male, 40-49 old also take medication Levothyroxine Sodium, and have Bipolar disorder . We study 13,532 people who have side effects while taking Valproic acid from FDA. Among them, 47 have Hypothyroidism. Find out below who they are, when they have Hypothyroidism and more.

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Valproic Acid

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. (latest outcomes from Valproic acid 13,822 users)


Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) has been reported by people with osteoporosis, hypothyroidism, high blood pressure, osteopenia, depression (latest reports from 77,433 Hypothyroidism patients).

On Feb, 17, 2017

13,532 people reported to have side effects when taking Valproic Acid.
Among them, 47 people (0.35%) have Hypothyroidism

Number of reports submitted per year:

Could Valproic acid cause Hypothyroidism?

Gender of people who have Hypothyroidism when taking Valproic Acid *:

  • female: 33.33 %
  • male: 66.67 %

Age of people who have Hypothyroidism when taking Valproic Acid *:

  • 0-1: 11.11 %
  • 2-9: 5.56 %
  • 10-19: 2.78 %
  • 20-29: 11.11 %
  • 30-39: 16.67 %
  • 40-49: 27.78 %
  • 50-59: 13.89 %
  • 60+: 11.11 %

Top conditions involved for these people *:

  • Bipolar Disorder (8 people, 17.02%)
  • Depression (6 people, 12.77%)
  • Schizoaffective Disorder (3 people, 6.38%)
  • Metabolic Syndrome (3 people, 6.38%)
  • Convulsion (2 people, 4.26%)

Top co-used drugs for these people *:

  • Levothyroxine Sodium (9 people, 19.15%)
  • Risperidone (8 people, 17.02%)
  • Zocor (6 people, 12.77%)
  • Lithium Carbonate (6 people, 12.77%)
  • Effexor (6 people, 12.77%)

Top other side effects for these people *:

  • Weight Increased (7 people, 14.89%)
  • Fatigue (7 people, 14.89%)
  • Rhabdomyolysis (6 people, 12.77%)
  • Fainting (6 people, 12.77%)
  • Chest Pain (6 people, 12.77%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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