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Review: could Wellbutrin cause Serotonin syndrome?

Summary: Serotonin syndrome is found among people who take Wellbutrin, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Cymbalta, and have Depression.

We study 49,281 people who have side effects while taking Wellbutrin from FDA and social media. Among them, 142 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

You are not alone: join a mobile support group for people who take Wellbutrin and have Serotonin syndrome >>>

 

 

 

 

Wellbutrin

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from 55,018 Wellbutrin users)

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder. (latest reports from 6,557 Serotonin syndrome patients)

On Jan, 1, 2015: 49,243 people reported to have side effects when taking Wellbutrin. Among them, 142 people (0.29%) have Serotonin Syndrome.

Trend of Serotonin syndrome in Wellbutrin reports

Time on Wellbutrin when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome14.29%57.14%0.00%0.00%0.00%28.57%0.00%

Age of people who have Serotonin syndrome when taking Wellbutrin * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%3.92%2.94%9.80%14.71%25.49%43.14%

Severity of Serotonin syndrome when taking Wellbutrin ** :

leastmoderateseveremost severe
Serotonin syndrome14.29%42.86%28.57%14.29%

How people recovered from Serotonin syndrome ** :

while on the drugafter off the drugnot yet
Serotonin syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (46 people, 32.39%)
  2. Anxiety (18 people, 12.68%)
  3. Pain (9 people, 6.34%)
  4. Anaesthesia (9 people, 6.34%)
  5. Smoking cessation therapy (7 people, 4.93%)

Top co-used drugs for these people * :

  1. Cymbalta (31 people, 21.83%)
  2. Paxil (25 people, 17.61%)
  3. Clonazepam (24 people, 16.90%)
  4. Lisinopril (21 people, 14.79%)
  5. Fentanyl (20 people, 14.08%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Serotonin Syndrome while taking Wellbutrin?

You are not alone! Join a mobile support group:
- support group for people who take Wellbutrin and have Serotonin Syndrome
- support group for people who take Wellbutrin
- support group for people who have Serotonin Syndrome

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More questions for: Wellbutrin, Serotonin syndrome

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    I was given a prescription for Wellbutrin in approximately 1998. I had has my ocular pressure checked a year prior to this and it was okay. At the time, I only needed to wear reading glasses, common in people over 45. I took the drug at the full prescribed dosage for two weeks. Immediately prior to the narrow angle glaucoma episode, my vision had actually seemed to improve. For one day, prior, I could read without reading glasses. The following night, I was watching tv, and things suddenly became foggy. It was actually as if a fog had enveloped the room. I could not see anything except to discern between light and dark areas. I had to have emergency laser surgery the next morning. I mentioned to the doctor that Iwas taking Wellbutrin to stop smoking, and asked if it could have caused the ocular pressure increase. he consulted the PDR, and said there was no mention of it causing increases in ocular pressure. One year later my primary care doctor again insisted that I stop smoking, and again I mentioned that I thought it might increase ocular pressure. She told me to take a half dose, I did, and I took it one week, at which time I again experienced another episode of narrow angle glaucoma. When I go to the doctor's office my pressure in my left eye was 72, and 68 in my right eye. I was then referred on a triage basis to another doctor. I spent the rest of the day in his office having drops administered every fifteen minutes(extremely painful). I had extensive laser surgery the next morning.It required over fifty shots from the laser machine into each eye, (also extremely painful). I had lost considerable peripheral AND CENTRAL VISION in my left eye, and a good deal in my right. As a result of having to have such extensive laser surgery I also had cataracts that began at 50% maturity. I was advised by the surgeon that I should wait to have the cataracts removed "until my vision and quality of life was so poor that I was ready to commit suicide" because having the cataracts removed would cause the pressure in my eyes to become very difficult to control, and that more than likely I would end up being black blind. I would never use Wellbutrin under any circumstances, and I always check to make sure that any new meds I may be put on don't have anything to do with an increase in ocular pressure. If they do, I refuse to take them. The surgeon said he was surprised that I didn't lose more vision than I did, and I am grateful that I didn't, and that he was a good surgen. He wrote an article concerning this case for a medical journal since he said he had been seeing a recent increase of narrow angle glaucoma.
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  • Wellbutrin caused my trigeminal neurlagia
    So I'm writing this to hopefully shed light to other users in the same position I was in. I had taken Wellbutrin for about 4 years. The pain experienced in my face was excruciatingly painful. It was just on one side of my face between my temple and upper lip. All the symptoms reflected Trigeminal Neuralgia. But even with an MRI nothing could be found. I suffered for 3 of those years with pain coming and going, not understanding what was going on. Finally one day I decided hell with Wellbutrin and just stopped taking it. It's been 6 months now and I have yet to have a single shred of pain. Coincidence? I doubt it.

More reviews for: Wellbutrin, Serotonin syndrome

Comments from related studies:

  • From this study (2 years ago):

  • I was in a MVA 2 1/2 years ago, I was an RN and was left unable to work. 3 months after the MVA I underwent a Hysterectomy found 4th grade Endometriosis with Adhesions. Only able to remove uterus, cervix is stuck to bowel unable to remove both ovaries retained. Underwent 2 rounds of 6 months each of Depro Lupron injections endometriosis symptoms subsided for 6-8 months and has since returned being cyclic for 12-15 days a month. During the time between the mva and hysterectomy 2 week period of stiffness, unable to move easily sent to rhuematologist found to recently had Parvo Recovered from that. Over time Rheumatologist diagnosed with connective tissue disorder started on Plaquenil and Prednisone. Diagnosed with Fibromyalgia. Sent to pain management diagnosed with pelvic floor tension myalgia, vuvlodynia, vaginal spasms, low testosterone and intersticial cystitis. Sent to sexual medicine doctor, found muscle damage from hysterectomy did trigger point injections and physical therapy deep tissue massage. Then I tore ACL and Medial Meniscus, unable to continue with pelvic pain doctor because gait was messing up what they were fixing. routine blood test found K+ to be 2.5 started on supplements of 40 meq a day of K+. Total body swelling started overnight started on Lasix, no improvement changed to Bumex edema decreased, potassium increased to 60 meq a day. I have been on pain medication since the MVA I have gone from Vicodin, valium to Percocet oxicontin, to MS Contin, Methadone, Butrans Patch and Now I am on Exalgo 12 mg once a day with 2 mg of dilaudid at bedtime. This does not seem to be working. I have constant abdominal/pelvic pain, vaginal spasms, bladder pain, kidney pain after the Bumex has worn off. I have developed Peripheral Neuropathy of my feet from taking crestor and hydroxychloroquine together, then they changed me to Lipitor, which is a statin and will do the same, Primary MD disagrees. I have suffered from Depression, anxiety, Panic attacks and migraines for over 10 years these are inherited conditions in Maternal Grandmother and Mother, migraines in Father also. They are now looking at Sjogrens Syndrome. Was on Vitamin B6 new medical journals say women should not take more than 10-50 mg a day-otc bottles say 100mg so pain management said I am suffering from vitamin B3 overdose and serotonin syndrome, trying to cut back on anti depressives and anti anxiety meds, but now is not really the time to do, I have been turned down for disability X2

    Reply

    Priti on May, 7, 2013:

    Become a vegan, leave animal protein, do yoga and chant " Nam myoho renge Kyo". Search the website "Soka Gakkai International" , practice this philosophy and see the results.

    Reply

  • From this study (2 years ago):

  • depression and anxiety x 12 years genetic. Migraines x 15 years genetic, Hyperlipidemia x7 years changed to lipitor from crestor due to peripheral neuropathy from taking plaquenil and crestor together, lipitor will do the same?? MVA january 2011, diagnosed with grade 4 endometriosis w/adhesions March 2011 partial hysterectomy. Bowel stuck to cervix, only uterus removed, both overies remain. 2 Rounds of 6 months depo lupron, diagnosed with connective tissue disorder, Parvo virus, inflammatory response june 2011, Chronic pain started after hysterectomy, pelvic floor tension myalgia, fibromyalgia diagnosed july 2011. Muscle Damage in abdomen after hysterectomy Interstitial cystitis diagnosed 2012, vulvodyna diagnosed 2012, routine bmp showed K+ level 2.7 12/2012, started on K+ 40 meq q day. Whole body swelling started 3/2013 started on lasix did not waork changed to bumex potassium level never higher than 3.2 currently taking k+ 60 meq a day. currently having issues with fibro, IC, Abd Pain, auto immune tissue inflammation and Endo has returned. Now they are thinking Serotonin Syndrome and possible sjogrnes syndrome as well as scleroderma.

    Reply

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