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Review: could Wellbutrin cause Serotonin syndrome?

We study 49,107 people who have side effects while taking Wellbutrin from FDA and social media. Among them, 142 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

Get connected: join a mobile support group for people who take Wellbutrin and have Serotonin syndrome >>>

Wellbutrin

Wellbutrin (latest outcomes from 54,854 users) has active ingredients of bupropion hydrochloride. It is often used in depression.

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,524 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.

On Sep, 17, 2014: 49,107 people reported to have side effects when taking Wellbutrin. Among them, 142 people (0.29%) have Serotonin Syndrome.

Trend of Serotonin syndrome in Wellbutrin reports

Time on Wellbutrin when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome14.29%57.14%0.00%0.00%0.00%28.57%0.00%

Age of people who have Serotonin syndrome when taking Wellbutrin * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%3.92%2.94%9.80%14.71%25.49%43.14%

Severity of Serotonin syndrome when taking Wellbutrin ** :

leastmoderateseveremost severe
Serotonin syndrome14.29%42.86%28.57%14.29%

How people recovered from Serotonin syndrome ** :

while on the drugafter off the drugnot yet
Serotonin syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (46 people, 32.39%)
  2. Anxiety (18 people, 12.68%)
  3. Pain (9 people, 6.34%)
  4. Anaesthesia (9 people, 6.34%)
  5. Smoking cessation therapy (7 people, 4.93%)

Top co-used drugs for these people * :

  1. Cymbalta (31 people, 21.83%)
  2. Paxil (25 people, 17.61%)
  3. Clonazepam (24 people, 16.90%)
  4. Lisinopril (21 people, 14.79%)
  5. Fentanyl (20 people, 14.08%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Serotonin Syndrome while taking Wellbutrin?

Get connected! Join a mobile support group:
- group for people who take Wellbutrin and have Serotonin Syndrome
- group for people who take Wellbutrin
- group for people who have Serotonin Syndrome

Comments from related studies:

  • From this study (1 year ago):

  • I was in a MVA 2 1/2 years ago, I was an RN and was left unable to work. 3 months after the MVA I underwent a Hysterectomy found 4th grade Endometriosis with Adhesions. Only able to remove uterus, cervix is stuck to bowel unable to remove both ovaries retained. Underwent 2 rounds of 6 months each of Depro Lupron injections endometriosis symptoms subsided for 6-8 months and has since returned being cyclic for 12-15 days a month. During the time between the mva and hysterectomy 2 week period of stiffness, unable to move easily sent to rhuematologist found to recently had Parvo Recovered from that. Over time Rheumatologist diagnosed with connective tissue disorder started on Plaquenil and Prednisone. Diagnosed with Fibromyalgia. Sent to pain management diagnosed with pelvic floor tension myalgia, vuvlodynia, vaginal spasms, low testosterone and intersticial cystitis. Sent to sexual medicine doctor, found muscle damage from hysterectomy did trigger point injections and physical therapy deep tissue massage. Then I tore ACL and Medial Meniscus, unable to continue with pelvic pain doctor because gait was messing up what they were fixing. routine blood test found K+ to be 2.5 started on supplements of 40 meq a day of K+. Total body swelling started overnight started on Lasix, no improvement changed to Bumex edema decreased, potassium increased to 60 meq a day. I have been on pain medication since the MVA I have gone from Vicodin, valium to Percocet oxicontin, to MS Contin, Methadone, Butrans Patch and Now I am on Exalgo 12 mg once a day with 2 mg of dilaudid at bedtime. This does not seem to be working. I have constant abdominal/pelvic pain, vaginal spasms, bladder pain, kidney pain after the Bumex has worn off. I have developed Peripheral Neuropathy of my feet from taking crestor and hydroxychloroquine together, then they changed me to Lipitor, which is a statin and will do the same, Primary MD disagrees. I have suffered from Depression, anxiety, Panic attacks and migraines for over 10 years these are inherited conditions in Maternal Grandmother and Mother, migraines in Father also. They are now looking at Sjogrens Syndrome. Was on Vitamin B6 new medical journals say women should not take more than 10-50 mg a day-otc bottles say 100mg so pain management said I am suffering from vitamin B3 overdose and serotonin syndrome, trying to cut back on anti depressives and anti anxiety meds, but now is not really the time to do, I have been turned down for disability X2

    Reply

    Priti on May, 7, 2013:

    Become a vegan, leave animal protein, do yoga and chant " Nam myoho renge Kyo". Search the website "Soka Gakkai International" , practice this philosophy and see the results.

    Reply

  • From this study (1 year ago):

  • depression and anxiety x 12 years genetic. Migraines x 15 years genetic, Hyperlipidemia x7 years changed to lipitor from crestor due to peripheral neuropathy from taking plaquenil and crestor together, lipitor will do the same?? MVA january 2011, diagnosed with grade 4 endometriosis w/adhesions March 2011 partial hysterectomy. Bowel stuck to cervix, only uterus removed, both overies remain. 2 Rounds of 6 months depo lupron, diagnosed with connective tissue disorder, Parvo virus, inflammatory response june 2011, Chronic pain started after hysterectomy, pelvic floor tension myalgia, fibromyalgia diagnosed july 2011. Muscle Damage in abdomen after hysterectomy Interstitial cystitis diagnosed 2012, vulvodyna diagnosed 2012, routine bmp showed K+ level 2.7 12/2012, started on K+ 40 meq q day. Whole body swelling started 3/2013 started on lasix did not waork changed to bumex potassium level never higher than 3.2 currently taking k+ 60 meq a day. currently having issues with fibro, IC, Abd Pain, auto immune tissue inflammation and Endo has returned. Now they are thinking Serotonin Syndrome and possible sjogrnes syndrome as well as scleroderma.

    Reply

Can you answer these questions (what is this?):

  • I'm on 1 1/12 mg of suboxone. would i have to go off of it if i need major surgery?
    I was taking about 5 to 15 mg of Percocet a day and wanted to get off them. If I don't take suboxone at night I get EXTREME discomfort down my left leg & can not sleep due to pressure on my lower back (that's why I had to take Percocet). I have tried NUMEROUS meds over the past 20 yrs & nothing work ...

  • Is dramamine ok to take with afib
    I want to take Dramamine for dizziness....is it ok with all these other meds. I have afib

  • Exercise intolerance
    I've been running for 2 years and recently it has become harder to run and I've lost 45 seconds off my pace. It's harder becuase my hips/.thighs hurt and not because of reduced lung capacity. It isn't temperature related. I've been taking 40 mg Prozac, 450 mg Wellbutrin, and .5 mg Xanax XR for 4 y ...

More questions for: Wellbutrin, Serotonin syndrome

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    I am on the very edge of crazy. So starting this is pushing ne way over. I'm 49 for crap sakes. I am so tired of the pain in my body and I am just tired, this is the last slap I can't anymore. Naturally alcohol I am sure is just about the end game along with cuts. Just want to bleed out and not hur ...

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On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used for depression. Find out below the conditions Wellbutrin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Wellbutrin used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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