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Review: could Wellbutrin cause Spotting?

Summary: Spotting could be caused by Wellbutrin, especially for people who are female, 30-39 old, have been taking the drug for < 1 month, also take Ortho evra, and have Contraception.

We study 48,943 people who have side effects while taking Wellbutrin from FDA and social media. Among them, 146 have Spotting. Find out below who they are, when they have Spotting and more.

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Wellbutrin (latest outcomes from 54,620 users) has active ingredients of bupropion hydrochloride. It is often used in depression.


Spotting (bleed during pregnancy) (latest reports from 57,451 patients) has been reported by people with birth control, menorrhagia, depression, endometriosis, menstruation irregular.

On Apr, 16, 2014: 48,927 people reported to have side effects when taking Wellbutrin. Among them, 146 people (0.30%) have Spotting. They amount to 0.25% of all the 57,439 people who have Spotting on eHealthMe.

Trend of Spotting in Wellbutrin reports

Time on Wellbutrin when people have Spotting * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Age of people who have Spotting when taking Wellbutrin * :


Severity of Spotting when taking Wellbutrin ** :

leastmoderateseveremost severe

How people recovered from Spotting ** :

while on the drugafter off the drugnot yet

Top conditions involved for these people * :

  1. Contraception (45 people, 30.82%)
  2. Depression (27 people, 18.49%)
  3. Premenstrual syndrome (4 people, 2.74%)
  4. Adhd (4 people, 2.74%)
  5. Bipolar disorder (3 people, 2.05%)

Top co-used drugs for these people * :

  1. Ortho evra (56 people, 38.36%)
  2. Wellbutrin xl (20 people, 13.70%)
  3. Wellbutrin sr (15 people, 10.27%)
  4. Zoloft (13 people, 8.90%)
  5. Nuvaring (12 people, 8.22%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Wellbutrin, Spotting

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On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used for depression. Find out below the conditions Wellbutrin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Wellbutrin used for and how effective is it:

Other drugs that are used to treat the same conditions:

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Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (13 months ago):

  • After starting with Vyvanse, spotting started after my 2nd period. I'm usually steady with a 28 day cycle. I'm due for my next period in a few days and am still spotting from the last one. Also having some bleeding after sex. I haven't lost weight and, if anything, Vyvanse and the Adderall, that I tried previously, caused weight gain. (Oddly enough, the Seroquel caused weight loss). I don't get any of the usual amphetamine symptoms. Similar to caffeine, it doesn't give me any energy or rapid pulse or keep my up, just a better ability to focus. Had a tubal ligation years ago so no birth control pills or hormones. Have a flare of canker sores the week before my period--not too bad this time. Dry mouth is probably due to all of the meds, had it before the Vyvanse, only slightly worse after taking the Vyvanse once in the morning. Vyvanse only lasts about two hours instead of all day. Will be talking about increasing the dosage at next visit. I suppose I could be starting menopause but it just seems weird that it would suddenly start after taking the Vyvanse after having such regular cycles.

    If the spotting and bleeding after sex are caused by Vyvanse, will they go away on their own? Can I expect it to get worse? Is there anything that I can do besides stopping and taking something else?


  • From this study (1 year ago):

  • I am 24 years old, female. I have been on Wellbutrin XL 150mg for 2 months, and I have been on Strattera for 1.5 weeks now, the first week I was on 25mg and the past 3 days or so I am taking 40mg. 1 day ago I found that I had very light spotting, a brown discharge. My period is only due in 2 weeks or so. I have never experienced this before. I am also on YAZ birth control have been using it for more than 4 years. I suspect the spotting is from the Strattera 40mg.

    I would like to know if it will stop after a month of getting used to the medication? or will this be a constant problem? Should I consult my phsyciatrist or rather talk to my GP?


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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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Related study

- Wellbutrin side effects


Related symptom

- Spotting



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