Review: could Xeloda cause Large Intestine Perforation?


Large intestine perforation is found among people who take Xeloda, especially for people who are male, 60+ old , have been taking the drug for < 1 month, also take medication Avastin, and have Rectal cancer . We study 27,978 people who have side effects while taking Xeloda from FDA and social media. Among them, 72 have Large intestine perforation. Find out below who they are, when they have Large intestine perforation and more.

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Xeloda has active ingredients of capecitabine. It is often used in breast cancer metastatic. (latest outcomes from Xeloda 28,214 users)

Large Intestine Perforation

Large intestine perforation (hole in large intestine) has been reported by people with rheumatoid arthritis, crohn's disease, high blood pressure, multiple sclerosis, pain (latest reports from 4,073 Large intestine perforation patients).

On Oct, 11, 2016

27,978 people reported to have side effects when taking Xeloda.
Among them, 72 people (0.26%) have Large Intestine Perforation

Number of reports submitted per year:

Could Xeloda cause Large intestine perforation?

Time on Xeloda when people have Large Intestine Perforation *:

  • < 1 month: 64.44 %
  • 1 - 6 months: 31.11 %
  • 6 - 12 months: 4.44 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Large Intestine Perforation when taking Xeloda *:

  • female: 33.82 %
  • male: 66.18 %

Age of people who have Large Intestine Perforation when taking Xeloda *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 1.56 %
  • 40-49: 14.06 %
  • 50-59: 34.38 %
  • 60+: 50.0 %

Top conditions involved for these people *:

  • Rectal Cancer (20 people, 27.78%)
  • Colon Cancer (9 people, 12.50%)
  • Colon Cancer Metastatic (7 people, 9.72%)
  • Rectal Cancer Metastatic (6 people, 8.33%)
  • Neoplasm Malignant (5 people, 6.94%)

Top co-used drugs for these people *:

  • Avastin (35 people, 48.61%)
  • Elplat (18 people, 25.00%)
  • Oxaliplatin (16 people, 22.22%)
  • Loxonin (7 people, 9.72%)
  • Zocor (5 people, 6.94%)

Top other side effects for these people *:

  • Peritonitis (12 people, 16.67%)
  • Diarrhoea (9 people, 12.50%)
  • Intestinal Ischaemia (7 people, 9.72%)
  • Rectal Perforation (6 people, 8.33%)
  • Mucosal Inflammation (5 people, 6.94%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

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