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From FDA reports: Xeloda and Large intestine perforation

This is a study of Large intestine perforation among people who take Xeloda. The study analyzes: the time on Xeloda when people have Large intestine perforation, age of these people, the severity of Large intestine perforation, how they recovered, and common conditions and drugs used besides Xeloda. In total 16,662 Xeloda users are studied. The study is created by eHealthMe based on reports from FDA and is updated regularly.

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Xeloda

Xeloda has active ingredients of capecitabine. It is used in colon cancer, breast cancer metastatic, cancer, breast cancer, colon cancer metastatic. Commonly reported side effects of Xeloda include diarrhea, nausea, palmar-plantar erythrodysaesthesia syndrome, nausea and vomiting, pain.

Large intestine perforation

Large intestine perforation has been reported by people with rheumatoid arthritis, high blood pressure, crohn's disease, multiple sclerosis, acne.

On Jun, 17, 2013: 16,662 people reported to have side effects when taking Xeloda. Among them, 48 people (0.29%) have Large Intestine Perforation.

Trend of Large intestine perforation in Xeloda reports

Time on Xeloda when people have Large intestine perforation * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Large intestine perforation55.56%40.74%3.70%0.00%0.00%0.00%0.00%

Age of people who have Large intestine perforation when taking Xeloda * :

0-12-910-1920-2930-3940-4950-5960+
Large intestine perforation0.00%0.00%0.00%0.00%0.00%13.64%40.91%45.45%

Severity of Large intestine perforation when taking Xeloda ** :

n/a

How people recovered from Large intestine perforation ** :

n/a

Top conditions involved for these people * :

  1. Rectal cancer (13 people, 27.08%)
  2. Colon cancer metastatic (4 people, 8.33%)
  3. Neoplasm malignant (4 people, 8.33%)
  4. Rectal cancer metastatic (4 people, 8.33%)
  5. Nausea (3 people, 6.25%)

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Top co-used drugs for these people * :

  1. Avastin (26 people, 54.17%)
  2. Oxaliplatin (16 people, 33.33%)
  3. Elplat (8 people, 16.67%)
  4. Zocor (6 people, 12.50%)
  5. Loxonin (6 people, 12.50%)

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* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

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Next: check whether large intestine perforation is from a drug or a condition

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On eHealthMe, Xeloda (capecitabine) is often used for colon cancer. Find out below the conditions Xeloda is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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