Xeloda and Large intestine perforation - from FDA reports


Summary

Large intestine perforation is found among people who take Xeloda, especially for people who are male, 60+ old , have been taking the drug for < 1 month, also take medication Avastin, and have Rectal cancer. This review analyzes which people have Large intestine perforation with Xeloda. It is created by eHealthMe based on reports of 28,732 people who have side effects when taking Xeloda from FDA , and is updated regularly.

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On Oct, 18, 2017

28,732 people reported to have side effects when taking Xeloda.
Among them, 74 people (0.26%) have Large intestine perforation


Number of reports submitted per year:

Could Xeloda cause Large intestine perforation?

Time on Xeloda when people have Large intestine perforation *:

  • < 1 month: 63.83 %
  • 1 - 6 months: 31.91 %
  • 6 - 12 months: 4.26 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Large intestine perforation when taking Xeloda *:

  • female: 32.86 %
  • male: 67.14 %

Age of people who have Large intestine perforation when taking Xeloda *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 1.52 %
  • 40-49: 13.64 %
  • 50-59: 34.85 %
  • 60+: 50.0 %

Top conditions involved for these people *:

  • Rectal Cancer (20 people, 27.03%)
  • Colon Cancer Metastatic (7 people, 9.46%)
  • Rectal Cancer Metastatic (6 people, 8.11%)
  • Neoplasm Malignant (5 people, 6.76%)
  • Nausea (4 people, 5.41%)

Top co-used drugs for these people *:

  • Avastin (37 people, 50.00%)
  • Oxaliplatin (16 people, 21.62%)
  • Zocor (5 people, 6.76%)
  • Fluorouracil (4 people, 5.41%)
  • Compazine (4 people, 5.41%)

Top other side effects for these people *:

  • Peritonitis (12 people, 16.22%)
  • Diarrhea (9 people, 12.16%)
  • Intestinal Ischaemia (7 people, 9.46%)
  • Rectal Perforation (6 people, 8.11%)
  • Sepsis (5 people, 6.76%)

* Approximation only. Some reports may have incomplete information.

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Large intestine perforation and Xeloda from FDA and eHealthMe reports

Xeloda

Xeloda has active ingredients of capecitabine. It is often used in breast cancer metastatic. (latest outcomes from Xeloda 29,056 users)

Large intestine perforation

Large intestine perforation (hole in large intestine) has been reported by people with rheumatoid arthritis, crohn's disease, high blood pressure, multiple sclerosis, pain (latest reports from 4,449 Large intestine perforation patients).

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