Zonisamide and Serotonin syndrome - from FDA reports


Serotonin syndrome is found among people who take Zonisamide, especially for people who are female, 30-39 old also take medication Gabapentin, and have Pelvic pain. This review analyzes which people have Serotonin syndrome with Zonisamide. It is created by eHealthMe based on reports of 3,992 people who have side effects when taking Zonisamide from FDA, and is updated regularly.

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If you take Zonisamide and have Serotonin syndrome, find out what symptoms you could have in 1 year or longer.

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On Apr, 12, 2017

3,992 people reported to have side effects when taking Zonisamide.
Among them, 14 people (0.35%) have Serotonin Syndrome

Number of reports submitted per year:

Could Zonisamide cause Serotonin syndrome?

Gender of people who have Serotonin Syndrome when taking Zonisamide *:

  • female: 76.92 %
  • male: 23.08 %

Age of people who have Serotonin Syndrome when taking Zonisamide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 23.08 %
  • 20-29: 0.0 %
  • 30-39: 76.92 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Top conditions involved for these people *:

  • Pelvic Pain (8 people, 57.14%)
  • Bipolar Disorder (4 people, 28.57%)
  • Abnormal Behavior (3 people, 21.43%)
  • Urination - Painful (1 person, 7.14%)
  • Pain (1 person, 7.14%)

Top co-used drugs for these people *:

  • Prochlorperazine (9 people, 64.29%)
  • Gabapentin (9 people, 64.29%)
  • Levothyroxine Sodium (8 people, 57.14%)
  • Citalopram Hydrobromide (8 people, 57.14%)
  • Buspirone Hcl (8 people, 57.14%)

Top other side effects for these people *:

  • Urinary Tract Infection (4 people, 28.57%)
  • Rhabdomyolysis (4 people, 28.57%)
  • Renal Failure Acute (3 people, 21.43%)
  • Hyperhidrosis (2 people, 14.29%)
  • Mydriasis (1 person, 7.14%)

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Serotonin syndrome when taking Zonisamide?


Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. (latest outcomes from Zonisamide 4,281 users)

Serotonin Syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) has been reported by people with depression, pain, stress and anxiety, major depression, insomnia (latest reports from 10,171 Serotonin syndrome patients).

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What would happen?

Forecast new side effects and undetected conditions when you take Zonisamide and have Serotonin syndrome.

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