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Review: could Zonisamide cause Serotonin syndrome?

We study 2,538 people who have side effects while taking Zonisamide from FDA and social media. Among them, 9 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

Stay connected: join a mobile support group for people who take Zonisamide and have Serotonin syndrome >>>

Zonisamide

Zonisamide (latest outcomes from 2,678 users) has active ingredients of zonisamide. It is often used in epilepsy.

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,498 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.

On Jul, 18, 2014: 2,538 people reported to have side effects when taking Zonisamide. Among them, 9 people (0.35%) have Serotonin Syndrome. They amount to 0.03% of all the 34,497 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Zonisamide reports

Time on Zonisamide when people have Serotonin syndrome * :

n/a

Gender of people who have Serotonin syndrome when taking Zonisamide * :

FemaleMale
Serotonin syndrome100.00%0.00%

Age of people who have Serotonin syndrome when taking Zonisamide * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%0.00%0.00%100.00%0.00%0.00%0.00%

Severity of Serotonin syndrome when taking Zonisamide ** :

n/a

How people recovered from Serotonin syndrome ** :

n/a

Top conditions involved for these people * :

  1. Pelvic pain (7 people, 77.78%)
  2. Pain (1 people, 11.11%)
  3. Dysuria (1 people, 11.11%)

Top co-used drugs for these people * :

  1. Prochlorperazine (8 people, 88.89%)
  2. Gabapentin (8 people, 88.89%)
  3. Levothyroxine sodium (8 people, 88.89%)
  4. Buspirone hcl (8 people, 88.89%)
  5. Promethazine (8 people, 88.89%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

  • From this study (2 weeks ago):

  • Seizures began 2 years after a MVA with a mild concussion, as Grand Mal. They reduced in severity to absence seizures with current medication regimen. I experience severe mood swings and have become so agitated I was committed to a mental health facility for evaluation at one time. Recently I awoke to find my left hand in a severe contracture. I had spent the previous day in 105 degree weather, unaware of the temperature due to my seizure medications. I am curious to know if this is drug related or an acute sign of MS.

    Reply

  • From this study (1 month ago):

  • can any of these meds cause trigeminal neuralgia?

    Reply

  • From this study (2 months ago):

  • 1st 3 symptoms due to a tooth extraction on 10/22/12 by an over-zealous dentist. After much effort the tooth finally came out and he exclaimed, "Most dentists would have sent a patient with a tooth like that to an oral surgeon, but I seem to have very good luck in getting them out." Little did I know that he had broken my maxillary bone and a week later I almost died from multiple bacterial infections in my sinus cavity. The bacteria damaged all 3 branches of my Trigeminal nerve and 3 surgeries later I have seen no improvement. Now have double vision in right eye and trigeminal pain 24/7. Gabapentin was a life saver, but only decreases pain and never eliminates it. Severe coughing started soon after starting gabapentin and cough is very wet, as if I have bronchitis. Chest x-Ray 4/7/14 shows normal and my doctor is perplexed. Neurologist has me taking Dextromorphan Hydrobromide, but seems to be ineffective. Help!

    Reply

    08trish on May, 5, 2014:

    Age 66, F, Southern California. After fighting Trigeminal Neuralgia with meds, Shots, and other things I has Gamma Knife Radiation. It took 1 1/2hrs, of radiation and got up and walked with not pain. I am now on my 2nd year and can't beleive I went through 10 years of pain. Might look into it, you might be happy with results for many.

    Reply

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Can you answer these questions (what is this?):

  • Has anyone experienced high glucose levels with zonisamide?
    Just started on 200 mg; was on 150 for a week and before that, 100 mg since early Aug. Have had flu-like symptoms for 2 days, fainted once, low b/p (stopped COQ 10 and Losartan) a month ago; extreme fatigue; loss of appetite; light-headed. Being light-headed is not new; I used to think it was low b ...

  • Whether use of zonisamide drug causes gum hypertrophy as a side effect?
    please inform whether zonisamide causes gum hypertrophy as a side effect so that our child can be given alternate drug in consultation with our neuro.

  • Does zonegran have sexual side effects?
    I currently take Topamax,lamictal and wellbutrin. I'm thinking of switching from Topamax to zonegran and I'm curious about the side effects. I do not have too much of a sex drive anymore and I would hate to make matters worse:(

More questions for: Zonisamide, Serotonin syndrome

More reviews for: Zonisamide, Serotonin syndrome

On eHealthMe, Zonisamide (zonisamide) is often used for epilepsy. Find out below the conditions Zonisamide is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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