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Review: Pseudoephedrine hydrochloride side effects

In this review, we analyze Pseudoephedrine hydrochloride side effects by the time on the drug, gender and age (0-60+) of the people who have side effects while taking Pseudoephedrine hydrochloride. The review is based on 187 people who have side effects while taking Pseudoephedrine hydrochloride from FDA and social media, and is updated regularly.

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What is Pseudoephedrine hydrochloride

Pseudoephedrine hydrochloride (latest outcomes from 674 users) has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion.

Other drugs that have the same active ingredients (pseudoephedrine hydrochloride): Novafed, Sudafed 12 Hour, Sudafed 24 Hour, Sudafed.

On Jan, 13, 2015: 187 people who reported to have side effects when taking Pseudoephedrine hydrochloride are studied


Most common side effects over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessIrritabilityAcne (skin problems that cause pimples)Edema (excess of watery fluid collecting in the cavities or tissues of the body)Intestinal SpasmShoulder PainLeg SwellingRectal Haemorrhage (bleeding from anus)
DeathAngerTremor (trembling or shaking movements in one or more parts of your body)Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)Shortness Of BreathDiarrheaInfusion Site Haemorrhage (bleeding from infusion site)
Dizziness AggravatedHeat Intolerance (feeling of being overheated)Sexual Dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)Sleepiness - During The Day (excess sleeping during day time)Tinnitus (a ringing in the ears)AnxietyHaemorrhoids (a swollen vein or group of veins in the region of the anus)
Menstrual Cycle Prolonged (long menstrual cycle)Confusional StateHeart Palpitations (feelings or sensations that your heart is pounding or racing)Chronic Depression (long lasting stress state of low mood)Encephalopathy (functioning of the brain is affected by some agent or condition)
Caecum Perforation (hole in caecum)Agitation (state of anxiety or nervous excitement)Goiter (a swelling of the thyroid gland)Sensory Loss (senses loss)Blood Pressure Increased
Bleeding TendencySleepiness (excess sleeping)Nausea And VomitingRash Follicular (redness of hair follicle)Blood Creatinine Increased
AnxietyDouble Vision (double vision)Fatigue (feeling of tiredness)Tension HeadachesMood Swings (an extreme or rapid change in mood)
Rapid Heart BeatParanoia (psychotic disorder characterized by delusions of persecution with or without grandeur)Nausea (feeling of having an urge to vomit)Rash (redness)Insomnia (sleeplessness)
Tiredness (feeling of tiredness)Anxiety AggravatedAnxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry)Drug IneffectiveHeadache (pain in head)
Restlessness (not able to rest)Hypertension (high blood pressure)Feeling JitteryNormochromic Normocytic Anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits)

Most common side effects by gender * :

Nausea (feeling of having an urge to vomit)Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Dry MouthCardiac Arrest
Hypertension (high blood pressure)Delirium (wild excitement)
Agitation (state of anxiety or nervous excitement)Multiple Drug Overdose
Fatigue (feeling of tiredness)Body Temperature Increased
VomitingDizziness Aggravated
Insomnia (sleeplessness)Hypertension (high blood pressure)
DeathDysphonia (speech disorder attributable to a disorder of phonation)
Headache (pain in head)Cough
Malaise (a feeling of general discomfort or uneasiness)Nausea (feeling of having an urge to vomit)

Most common side effects by age * :

n/aHallucination (an experience involving the perception of something not present)Leukocytosis (increased white blood cells)Hypertension (high blood pressure)Fatigue (feeling of tiredness)ConstipationNausea (feeling of having an urge to vomit)Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Normochromic Normocytic Anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits)Tachycardia (a heart rate that exceeds the range of 100 beats/min)DeathOvarian Cancer Nos (cancer of ovary)Heart Rate IncreasedRectal Haemorrhage (bleeding from anus)
Proteinuria (presence of protein in the urine)Cardiac ArrestDrug AbuseRespiratory Arrest (cessation of normal respiration due to failure of the lungs to function effectively)Drug Effect IncreasedInfusion Site Haemorrhage (bleeding from infusion site)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)Body Temperature IncreasedBlood Gases AbnormalDry MouthPanic AttackFatigue (feeling of tiredness)
Headache (pain in head)Delirium (wild excitement)Blood Bicarbonate DecreasedAgitation (state of anxiety or nervous excitement)Aspartate Aminotransferase IncreasedInfluenza Like Illness
Blood Creatinine IncreasedMultiple Drug OverdoseBlood Glucose IncreasedParanoia (psychotic disorder characterized by delusions of persecution with or without grandeur)Blood Uric Acid IncreasedDepression Nec
Blood Pressure IncreasedNausea (feeling of having an urge to vomit)Cardiac Failure CongestiveHeadache Nos (pain in head)Blood Creatine IncreasedMalaise (a feeling of general discomfort or uneasiness)
Encephalopathy (functioning of the brain is affected by some agent or condition)Acne (skin problems that cause pimples)Cold SweatSkin Lesion Nos (redness)Abdominal Pain UpperAllergy Aggravated
VomitingRash (redness)Cardiomyopathy (weakening of the heart muscle)Pelvic MassAgitation (state of anxiety or nervous excitement)Alopecia (absence of hair from areas of the body)
Benign Intracranial Hypertension (benign intracranial hypertension (bih) is a headache syndrome)Shivering (felling of cold)Arrhythmia (irregular heartbeat)Hallucination (an experience involving the perception of something not present)Sensory Loss (senses loss)Sedation

* Some reports may have incomplete information.

Browse Pseudoephedrine hydrochloride side effects from A to Z:

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Are you taking Pseudoephedrine hydrochloride?

Comments from related studies:

  • From this study (3 weeks ago):



  • From this study (1 month ago):

  • Was taking sudaphed for mega sinuses and chronic sinutitis.Have to take more now to get relief.Now trying to withdraw and this walking problem started. Legs feel real heavy.Move hips to walk instead of legs because of the pain.Also legs get fatigued real easy and then weakness comes over and have to sit down.


  • From this study (1 month ago):

  • Red rash over arms. Hardly raised. Not itchy or painful


Post a new comment    OR    Read more comments

Can you answer these questions (Ask a question):

  • Hallucinations and skin thas red and hurts (1 answer)
    I am having horrable hallucinations.manic episodes because i slam on the brakes to avoid people or animals that are not there.i feel like im going to razy.high bood pressure, heavy breathing and face and body have spoys that are like a sun burn and blisters in my mouth.emergency room accused me of being drugy and said the blood tests came back that i had meth in my blood..i not breathing deep enough and would stop by hen the tubes were removed.i also experience episodes if slured speech and confusion.i am no way a meth user ad soon as it was thought that i used drugs.i was discharged i read my paperwork that said.METHAMPHETAMINE USER. WHY?- I need answers. Would any or all cause this? But i have still the problems i went there for am i allergic to my meds levothyroxine?
  • Wondering if dexilant is causing my problem (2 answers)
    have had my prostate checked by urologist and prostate is slightly enlarged but not enough to cause problems.urinary track ok,bladder ok etc.
    drank a liter of water and bladder emptied ok in test.
    seem to urinate good after consuming coffee or beer but lately having more whiskey than beer.
    when I drink whiskey I don't urinate much in evening but have to get up 3 or 4 times during the night to urinate.amlodipine,ramipril,atenolol are for blood pressure.
    rosuvastatin for cholesterol,methocarbonal for sore back,pseudoephedrine and ibuprofen are for sinus headaches caused from smoking cigarettes.
    so anybody out there think dexilant might be causing my urinating during the night problem ?
    plus when I do go during the night I don't seem to completely empty my bladder!
    any ideas ?
  • Could this drug cause periodontal bone loss, bone loss around teeth (4 answers)
    Do you suffer from periodontal bone loss or periodontal disease, or bone loss around teeth after taking this drug? Are your sodium levels low after taking this drug? I am a dentist and keep my teeth plaque free, but have had periodontal bone loss for which, I believe, must be drug related.
  • Can i take saphris with sudafed and benadryl
    Is it ok to take sudafed and Benadryl cold and flu tablets with saphris bipolar tablets?
  • How do i become a part of this study?
    I was taking Sudafed and had a stroke took Sudafed again and had a second stroke

More questions for: Pseudoephedrine hydrochloride

You may be interested at these reviews (Write a review):

  • Skin burning sensation with delsym (1 response)
    I had been sick for about a week and had been taking Sudafed every 4-6 hours for congestion for the past couple of days. I also take wellbutrin SR daily as an antidepressant. I started taking the suspension formula of Delsym 12 hour release about 24 hours previously (so I had already had two doses) I took my third dose. Within 10-20 minutes of swallowing it I started to feel things were somewhat surreal and then noticed a skin burning sensation particularly on my neck and face. The skin burning sensation intensified spreading throughout my body and caused a panic attack. The skin burning persisted off and on for at least the next 12 hours. I have not taken delsym since and am no longer experiencing the feeling.
  • Bad nosebleed (sudafed related?) (1 response)
    I have the rhinitis as a result of rebound syndrome from using nasal sprays for years. I use the Flonase to somewhat alleviate the need for the over-the-counter sprays (first two drugs listed). In spite of that, I rarely, if ever, have nosebleeds. I also rarely, if ever, get colds. However, yesterday I decided I definitely was getting a cold and decided to take some 12-hour Sudafed. I took my second dose a couple of hours early and next thing you know my nose was bleeding fairly profusely all night. I tried the recommended method of tilting the head forward and holding the nose shut for 10 minutes but all that did was fill my head with blood and when I let go all kinds of blood and clotted blood came out of my nose and mouth making a huge mess. What worked for me after hours of trying was tilting the head slightly back, putting up with the blood trickling down my throat and trying not to breathe or irritate the bleeding nostril. Periodically I'd have to cough up or blow out some clotting because it became too much to handle but eventually this method worked for me. I've decided to refrain from taking anymore Sudafed or nasal sprays for the time being at least until I'm sure the nosebleed is completely gone.

More reviews for: Pseudoephedrine hydrochloride

On eHealthMe, Pseudoephedrine Hydrochloride (pseudoephedrine hydrochloride) is often used for nasal congestion. Find out below the conditions Pseudoephedrine Hydrochloride is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Pseudoephedrine Hydrochloride used for and how effective is it:

Other drugs that are used to treat the same conditions:

Studies of common Pseudoephedrine hydrochloride drug interactions:

Browse Pseudoephedrine hydrochloride drug interactions with drugs from A to Z:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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