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Review: Tizanidine hydrochloride side effects

In this review, we analyze Tizanidine hydrochloride side effects by the time on the drug, gender and age (0-60+) of the people who have side effects while taking Tizanidine hydrochloride. The review is based on 1,197 people who have side effects while taking Tizanidine hydrochloride from FDA and social media, and is updated regularly.

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What is Tizanidine hydrochloride

Tizanidine hydrochloride (latest outcomes from 1,543 users) has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms.

Other drugs that have the same active ingredients (tizanidine hydrochloride): Zanaflex.

On Jan, 4, 2015: 1,197 people who reported to have side effects when taking Tizanidine hydrochloride are studied


Most common side effects over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hypotension (abnormally low blood pressure)Alanine Aminotransferase IncreasedHallucination, Visual (seeing things that aren't there)High Blood PressureHypokalaemia (low potassium)Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)Dysaesthesia (abnormal sensation)Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)Aspartate Aminotransferase IncreasedBlood Creatine Phosphokinase IncreasedBasilar Migraine (migraine with neurological symptoms related to the brain stem or with neurological symptoms on both sides of the body)Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)VomitingParotitis (inflammation of a parotid gland)Pain
DizzinessDiffuse Large B-cell Lymphoma (cancer of b cells, a type of white blood cell)Aspartate Aminotransferase IncreasedHot Flushes (sudden feelings of heat)Neutropenic Sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)Low Blood Pressure (abnormally low blood pressure)Pyrexia (fever)
Suicide AttemptAnorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)Intentional OverdoseConstipation AggravatedFungal Sepsis (whole body infection by fungus)Gastric Ulcer (stomach ulcer)Erectile DysfunctionVomiting
PneumoniaSomnolence (a state of near-sleep, a strong desire for sleep)Hearing LossBack InjuryConvulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)Loss Of ConsciousnessSwollen Tongue (swelling of tongue)Nausea (feeling of having an urge to vomit)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)Pain - Head (pain in head)Hair LossAnaemia (lack of blood)Hypoaesthesia (reduced sense of touch or sensation)Diarrhoea
Pyrexia (fever)Acute Myocardial Infarction (acute heart attack)Stiffness In A Joint (difficulty in moving neck)Rigors (an episode of shaking or exaggerated shivering)Condition AggravatedMuscular Weakness (muscle weakness)Abdominal Pain
Aspartate Aminotransferase IncreasedMuscle Rigidity (muscle stiffness)Headache (pain in head)Depression Postmenopausal (depression during menopause is a mood disorder characterized by symptoms of persistent sadness, and apathy, as well as physical symptoms)Pericardial Effusion (fluid around the heart)Disturbance In AttentionHeadache (pain in head)
Alanine Aminotransferase IncreasedNausea (feeling of having an urge to vomit)Low Platelet Count (decrease of platelets in blood)Personality ChangeNeutropenia (an abnormally low number of neutrophils)Emotional DistressFall
Fatigue (feeling of tiredness)Blood Lactate Dehydrogenase IncreasedIntervertebral Disc Degeneration (spinal disc degeneration)Short-term Memory LossInsomnia (sleeplessness)Pain In ExtremityDyspnoea (difficult or laboured respiration)

Most common side effects by gender * :

Nausea (feeling of having an urge to vomit)Hypotension (abnormally low blood pressure)
PainPyrexia (fever)
Fatigue (feeling of tiredness)Fatigue (feeling of tiredness)
Pyrexia (fever)Headache (pain in head)
Pruritus (severe itching of the skin)Asthenia (weakness)
Abdominal PainDizziness
Oedema Peripheral (superficial swelling)Pain
FallThrombocytopenia (decrease of platelets in blood)

Most common side effects by age * :

Accidental ExposureNeuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)Cardiac DisorderVentricular Fibrillation (abnormally irregular heart rhythm)Fatigue (feeling of tiredness)Nausea (feeling of having an urge to vomit)PainVomiting
Rectal Prolapse (falling of rectum from normal place)Cardiac DisorderVomitingCardiac ArrestDyspnoea (difficult or laboured respiration)Pyrexia (fever)Anaemia (lack of blood)Hypotension (abnormally low blood pressure)
Cardio-respiratory Arrest (sudden dysfunction of heart and lungs)Epstein-barr Virus InfectionTorsade De Pointes (a abnormal heart rate with abnormal beating pattern)Suicide AttemptHeadache (pain in head)AnxietyMalaise (a feeling of general discomfort or uneasiness)
PneumoniaInjuryPainPyrexia (fever)FallPneumoniaSomnolence (a state of near-sleep, a strong desire for sleep)
Sudden DeathHypersensitivityComa (state of unconsciousness lasting more than six hours)Loss Of ConsciousnessFatigue (feeling of tiredness)Emotional DistressDiarrhoea
Bradyarrhythmia (heart slowness)Abdominal TendernessDrug DependenceSyncope (loss of consciousness with an inability to maintain postural tone)Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)Abdominal PainPyrexia (fever)
Somnolence (a state of near-sleep, a strong desire for sleep)Cholecystitis Chronic (long lasting infection of gallbladder)Upper Respiratory Tract InfectionAsthenia (weakness)VomitingCoughAsthenia (weakness)
Abscess (pus)Decreased Appetite (decreased appetite occurs when you have a reduced desire to eat)Drug IneffectiveMultiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)DizzinessNausea (feeling of having an urge to vomit)Nausea (feeling of having an urge to vomit)
Hypotonia (low muscle tone)Food Intolerance (inability to have food)Sudden DeathMalaise (a feeling of general discomfort or uneasiness)Blood Pressure Decreased (abnormally low blood pressure)Hypophagia (reduced food intake)Hyperkalaemia (damage to or disease of the kidney)
Tremor (trembling or shaking movements in one or more parts of your body)Abdominal PainBlood Potassium DecreasedAltered State Of Consciousness (altered state of mind)ConstipationDepressionDecreased Appetite (decreased appetite occurs when you have a reduced desire to eat)

* Some reports may have incomplete information.

Browse Tizanidine hydrochloride side effects from A to Z:

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Are you taking Tizanidine hydrochloride?

Comments from related studies:

  • From this study (1 week ago):

  • low in iron


  • From this study (3 weeks ago):

  • I have an ache and pain in right leg, started hurting in thigh area, then is now moving down my leg and into heel area


  • From this study (3 weeks ago):

  • i started doing things I normally wouldn't do I had no remorse or care about doing them didn't remember doing them


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    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
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  • Off label use of drugs for peripheral neuropathy causing memory loss (1 response)
    I have peripheral neuropathy with standard symptoms of burning, tingling, stabbing pain on the tops of my feet. I have had this condition for over 15 years getting worse over time. The last 5 years I have seen a couple of doctors and through trial and error we settled on a combination of Savella and Methadone to dampen the pain which can go from a nuisance constant 2 to "I'm ready to cut off my feet" constant 8. Taking Savella and Methadone keeps me at a 2 or below except in the evenings when it can get to 5 or 6 and keep me awake. Over a period of a year or so, and I can't remember when it started, I was given Tizanidine, Pramipexole, Oxcarbazpine, Gabapentin and Lyrica (at separate times). I do not remember which of these I was on for the longest or at what point I noticed I was unable to remember what happened the day before, conversations I had with co-workers, decisions and agreements with my manager and things I had done earlier in the week or month. I'm sure a timeline could be put together but since I had lost short term memory I could not do it even now. When I finally figured out what was happening, I was close to losing my job as a Computer Hardware Engineer, which requires extreme concentration and memory. I stopped taking whatever I was on at the time and looked for anything to help me regain my memory and ability to concentrate. I am now taking herbal supplements and using iPhone apps to help me regain concentration and memory. After over 6 months of being off of these drugs I am close to having my previous facilities back. I cannot stress enough the importance of a doctor talking with their patients about memory loss and the ability to concentrate when taking these types of drugs. One of my doctors just gave me Topiramate to try and help with the evening pain and after reading the side effects I will not even try it. Better to be in pain and keep my job.

    What really bothers me is I think simply taking one additional pill of Savella will solve my pain issue, but my doctors scoff whenever I make a suggestion and try to put me on something else. After making a medication suggestion one doctor threatened to take me off all medication. I guess he showed me who's the boss. All this is causing me to trust doctors less and less.

More reviews for: Tizanidine hydrochloride

On eHealthMe, Tizanidine Hydrochloride (tizanidine hydrochloride) is often used for muscle spasms. Find out below the conditions Tizanidine Hydrochloride is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Tizanidine Hydrochloride used for and how effective is it:

Other drugs that are used to treat the same conditions:

Studies of common Tizanidine hydrochloride drug interactions:

Browse Tizanidine hydrochloride drug interactions with drugs from A to Z:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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