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Review: Tizanidine hydrochloride side effects

In this review, we analyze Tizanidine hydrochloride side effects by the time on the drug, gender and age (0-60+) of the people who have side effects while taking Tizanidine hydrochloride. The review is based on 1,211 people who have side effects while taking Tizanidine hydrochloride from FDA and social media, and is updated regularly.

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What is Tizanidine hydrochloride

Tizanidine hydrochloride (latest outcomes from 1,556 users) has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms.

Other drugs that have the same active ingredients (tizanidine hydrochloride): Zanaflex.

On Mar, 9, 2015: 1,211 people who reported to have side effects when taking Tizanidine hydrochloride are studied


Most common side effects over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hypotension (abnormally low blood pressure)Aspartate Aminotransferase IncreasedHallucination, Visual (seeing things that aren't there)High Blood PressureHypokalaemia (low potassium)Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)Dysaesthesia (abnormal sensation)Fatigue (feeling of tiredness)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)Alanine Aminotransferase IncreasedBlood Creatine Phosphokinase IncreasedHair LossNeutropenia (an abnormally low number of neutrophils)VomitingParotitis (inflammation of a parotid gland)Pain
PneumoniaDiffuse Large B-cell Lymphoma (cancer of b cells, a type of white blood cell)Aspartate Aminotransferase IncreasedConstipation AggravatedNeutropenic Sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)Low Blood Pressure (abnormally low blood pressure)Pyrexia (fever)
Nausea (feeling of having an urge to vomit)Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)Intentional OverdoseBack InjuryFungal Sepsis (whole body infection by fungus)Gastric Ulcer (stomach ulcer)Erectile DysfunctionVomiting
Pyrexia (fever)Hepatic Function AbnormalMood Swings (an extreme or rapid change in mood)Depression Postmenopausal (depression during menopause is a mood disorder characterized by symptoms of persistent sadness, and apathy, as well as physical symptoms)Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)Loss Of ConsciousnessSwollen Tongue (swelling of tongue)Nausea (feeling of having an urge to vomit)
Suicide AttemptBlood Lactate Dehydrogenase IncreasedMissed Periods (skipped menstrual cycle)DizzinessAnaemia (lack of blood)Emotional DistressDiarrhoea
DizzinessAnorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)Pain - Head (pain in head)Basilar Migraine (migraine with neurological symptoms related to the brain stem or with neurological symptoms on both sides of the body)Condition AggravatedHypoaesthesia (reduced sense of touch or sensation)Abdominal Pain
Coma (state of unconsciousness lasting more than six hours)Somnolence (a state of near-sleep, a strong desire for sleep)Stiffness In A Joint (difficulty in moving neck)Hot Flushes (sudden feelings of heat)Pericardial Effusion (fluid around the heart)Muscular Weakness (muscle weakness)Headache (pain in head)
Loss Of ConsciousnessNausea (feeling of having an urge to vomit)Hearing LossMigraine (headache)Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)Deep Vein Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)Fall
Fatigue (feeling of tiredness)Muscle Rigidity (muscle stiffness)Low Platelet Count (decrease of platelets in blood)Weight Gain - UnintentionalInsomnia (sleeplessness)Sudden DeathDyspnoea (difficult or laboured respiration)

Most common side effects by gender * :

Nausea (feeling of having an urge to vomit)Hypotension (abnormally low blood pressure)
PainPyrexia (fever)
Fatigue (feeling of tiredness)Pneumonia
VomitingFatigue (feeling of tiredness)
Pyrexia (fever)Headache (pain in head)
Pruritus (severe itching of the skin)Dizziness
Abdominal PainAsthenia (weakness)
DiarrhoeaThrombocytopenia (decrease of platelets in blood)
Oedema Peripheral (superficial swelling)Pain

Most common side effects by age * :

Accidental ExposureNeuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)Cardiac DisorderVentricular Fibrillation (abnormally irregular heart rhythm)Fatigue (feeling of tiredness)Nausea (feeling of having an urge to vomit)PainVomiting
Rectal Prolapse (falling of rectum from normal place)Cardiac DisorderVomitingCardiac ArrestDyspnoea (difficult or laboured respiration)Pyrexia (fever)Anaemia (lack of blood)Hypotension (abnormally low blood pressure)
Cardio-respiratory Arrest (sudden dysfunction of heart and lungs)Epstein-barr Virus InfectionTorsade De Pointes (a abnormal heart rate with abnormal beating pattern)Suicide AttemptHeadache (pain in head)PneumoniaMalaise (a feeling of general discomfort or uneasiness)
PneumoniaInjuryPainLoss Of ConsciousnessFatigue (feeling of tiredness)AnxietySomnolence (a state of near-sleep, a strong desire for sleep)
Sudden DeathHypersensitivityComa (state of unconsciousness lasting more than six hours)Pyrexia (fever)FallEmotional DistressAsthenia (weakness)
Bradyarrhythmia (heart slowness)Abdominal TendernessDrug DependenceSyncope (loss of consciousness with an inability to maintain postural tone)Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)Abdominal PainPyrexia (fever)
Somnolence (a state of near-sleep, a strong desire for sleep)Cholecystitis Chronic (long lasting infection of gallbladder)Upper Respiratory Tract InfectionAsthenia (weakness)VomitingCoughDiarrhoea
Abscess (pus)Decreased Appetite (decreased appetite occurs when you have a reduced desire to eat)Drug IneffectiveMultiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)DizzinessDiverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)Nausea (feeling of having an urge to vomit)
Hypotonia (low muscle tone)Food Intolerance (inability to have food)Sudden DeathMalaise (a feeling of general discomfort or uneasiness)Blood Pressure Decreased (abnormally low blood pressure)Nausea (feeling of having an urge to vomit)Hyperkalaemia (damage to or disease of the kidney)
Tremor (trembling or shaking movements in one or more parts of your body)Abdominal PainBlood Potassium DecreasedAltered State Of Consciousness (altered state of mind)ConstipationHypophagia (reduced food intake)Decreased Appetite (decreased appetite occurs when you have a reduced desire to eat)

* Some reports may have incomplete information.

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Are you taking Tizanidine hydrochloride?




On eHealthMe, Tizanidine Hydrochloride (tizanidine hydrochloride) is often used for muscle spasms. Find out below the conditions Tizanidine Hydrochloride is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Tizanidine Hydrochloride used for and how effective is it:

Other drugs that are used to treat the same conditions:

Studies of common Tizanidine hydrochloride drug interactions:

Browse Tizanidine hydrochloride drug interactions with drugs from A to Z:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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