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Review: Zestoretic side effects

In this review, we analyze Zestoretic side effects by the time on the drug, gender and age (0-60+) of the people who have side effects while taking Zestoretic. The review is based on 2,540 people who have side effects while taking Zestoretic from FDA and social media, and is updated regularly.

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What is Zestoretic

Zestoretic (latest outcomes from 2,604 users) has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure.

Other drugs that have the same active ingredients (hydrochlorothiazide; lisinopril): Prinzide, Lisinopril And Hydrochlorothiazide.

On Dec, 2, 2014: 2,540 people who reported to have side effects when taking Zestoretic are studied


Most common side effects over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe)Cardiac Failure CongestiveRenal Failure Acute (rapid kidney dysfunction)DiarrhoeaCerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)Hypotension (abnormally low blood pressure)Angioedema (rapid swelling of the dermis)Pain
Diabetes Mellitus Inadequate ControlCoughSepsis (a severe blood infection that can lead to organ failure and death)Dyspnoea (difficult or laboured respiration)Headache (pain in head)Dehydration (dryness resulting from the removal of water)Toxic Skin Eruption (skin breakdown due to toxic substance)Nausea (feeling of having an urge to vomit)
Interstitial Lung DiseaseChronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe)Respiratory Failure (inadequate gas exchange by the respiratory system)Alveolitis (inflammation in the socket of a tooth)Malaise (a feeling of general discomfort or uneasiness)Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)Hypertension (high blood pressure)
Coronary Arterial Stent InsertionDyspnoea (difficult or laboured respiration)Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)Eosinophilia (eosinophil count in the peripheral blood exceeds)Heart Rate IrregularSyncope (loss of consciousness with an inability to maintain postural tone)Breast Cancer MetastaticFatigue (feeling of tiredness)
Cytomegalovirus InfectionAtrial Fibrillation (fibrillation of the muscles of the atria of the heart)Pyrexia (fever)Blood Alkaline Phosphatase IncreasedTransient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)Tongue Oedema (swelling of tongue)Injury
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)Sepsis (a severe blood infection that can lead to organ failure and death)DiarrhoeaVomitingHypertension (high blood pressure)Hyperkalaemia (damage to or disease of the kidney)Cholecystitis (infection of gallbladder)Anxiety
Bacterial InfectionDrug HypersensitivityNausea (feeling of having an urge to vomit)DizzinessTympanic Membrane Perforation (a break in continuity of ear drum)Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)SurgeryAsthenia (weakness)
Blood Creatinine AbnormalHeart Rate IrregularVomitingRespiratory Distress (difficulty in breathing)Renal Failure (kidney dysfunction)Cardiac FailureErythema (redness of the skin)Hypotension (abnormally low blood pressure)
Loss Of ConsciousnessRenal Failure Acute (rapid kidney dysfunction)Lung Infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)Gastric Ulcer (stomach ulcer)Tinnitus (a ringing in the ears)Neutropenia (an abnormally low number of neutrophils)Cervix Erythema (cervix redness)Decreased Appetite (decreased appetite occurs when you have a reduced desire to eat)
Back PainRenal Failure (kidney dysfunction)Muscle Strain (an injury to a muscle in which the muscle fibres tear)CoughDeafnessDrug Eruption (adverse drug reaction of the skin)Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)Fall

Most common side effects by gender * :

Nausea (feeling of having an urge to vomit)Drug Ineffective
Chest PainMyocardial Infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Asthenia (weakness)Hypotension (abnormally low blood pressure)
Fatigue (feeling of tiredness)Pyrexia (fever)
FallNausea (feeling of having an urge to vomit)
Hypotension (abnormally low blood pressure)Renal Failure Acute (rapid kidney dysfunction)
Hypertension (high blood pressure)Fatigue (feeling of tiredness)
Weight IncreasedHyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Headache (pain in head)Coronary Artery Disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dehydration (dryness resulting from the removal of water)Constipation

Most common side effects by age * :

Hypokalaemia (low potassium)n/aHepatitis Nos (inflammation of the liver)Somnolence (a state of near-sleep, a strong desire for sleep)Oedema Peripheral (superficial swelling)Hypertension (high blood pressure)Nausea (feeling of having an urge to vomit)Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Amyotrophic Lateral Sclerosis (nervous system disease that attacks nerve cells called neurons in your brain and spinal cord)Hypotension (abnormally low blood pressure)SedationAnxietyChest PainAnxietyAsthenia (weakness)
CoughProthrombin Level DecreasedDiabetes Mellitus Inadequate ControlPainWeight IncreasedDepressionNausea (feeling of having an urge to vomit)
Hypokalaemic Syndrome (serum concentration of potassium <3.5)Thrombocytopenia (decrease of platelets in blood)Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)InjuryNausea (feeling of having an urge to vomit)PainFatigue (feeling of tiredness)
Sinus Bradycardia (an unusually slow heartbeat due to heart disease)Haemoglobin DecreasedType 2 Diabetes MellitusFluid Retention (an abnormal accumulation of fluid in the blood)Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling)Hypotension (abnormally low blood pressure)Hypotension (abnormally low blood pressure)
Urticaria (rash of round, red welts on the skin that itch intensely)Hepatomegaly (abnormal enlargement of the liver)HypersensitivityDeep Vein Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)Drug IneffectiveChest PainMyocardial Infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Melaena (the passage of black, tarry stools)Dermatitis Nos (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)Subclavian Vein Thrombosis (abnormal condition in which a clot develops within the subclavian or axillary vein)Pulmonary Embolism (blockage of the main artery of the lung)DepressionGastrooesophageal Reflux Disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)Pyrexia (fever)
Throat IrritationCoagulation Factor V Level DecreasedPainDysphagia (condition in which swallowing is difficult or painful)ConstipationAnaemia (lack of blood)Fall
Pancreatitis Acute (sudden inflammation of pancreas)Cerebral Oedema (swelling of brain)Thrombosis (formation of a blood clot inside a blood vessel)Dyspnoea Nos (difficult or laboured respiration)Renal Failure (kidney dysfunction)DiarrhoeaDrug Ineffective
Respiratory Failure (inadequate gas exchange by the respiratory system)Convulsions Nos (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)Affective Disorder (mental disorder)Platelet Count DecreasedFatigue (feeling of tiredness)FallRenal Failure Acute (rapid kidney dysfunction)

* Some reports may have incomplete information.

Browse Zestoretic side effects from A to Z:

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Comments from related studies:

  • From this study (1 month ago):

  • Generally happens every couple of mnths has now moved to mnthly and las two episodes were within 2 weeks of each other. Oct 12-13& oct31-nov 1. I believe pain to be mittleschmirtz the hot flashes and vomiting just started within the last year.


  • From this study (1 month ago):

  • lips have been sort of numb and eyes feel like they are abut to fall out of my head. My face is red and skin is dry and itchy. Gaining weight and have lowered calories to 300 per day and increased water to one and a half gallons a day.


  • From this study (1 month ago):

  • Started using omeprazole 2 months ago. Just noticed skipped heartbeats. 1-2 per minute.


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Can you answer these questions (Ask a question):

  • I feel cold all the time
    (Asked by a 54 year old woman who has Feeling Cold, and takes Metformin, Lisinopril And Hydrochlorothiazide)
    I feel cold all the time even when it is warm out.
  • Is nyquil / alkaseltzer plus safe to take with parkinson's meds: azilect and mirapex er
    (Asked by a 64 year old woman who has Cold Symptoms, and takes Lisinopril And Hydrochlorothiazide)
    What is safe to take with Parkinson's meds?? I am taking Azilect and Mirapex ER; along with high blood pressure meds; lisinopril and hydrochloride ; and anti-inflammatory Diclophenic . I want to know what cold/cough meds are safe to take without drug interactions.
  • Mixing methamphatamine and lisinapril hydrocloathyaxide together is it dangetous
    (Asked by a 42 year old woman who has Chest Tightness Or Pressure, Lightheadedness - Dizzy, Hand Tingling Numb, Shortness Of Breath, and takes Hydrochlorothiazide, Lisinopril And Hydrochlorothiazide, Methamphetamine Hydrochloride)
    I feel really terrible shortness of breath blood pressure keeps dropping up and down my chest is very heavy and tight
  • What would cause a false positive for valium? i.e. i didnt take it, but has shown up in several of my urine test (1 answer)
    (Asked by a 32 year old woman who takes Suboxone, Lisinopril And Hydrochlorothiazide, Melatonin, Benadryl, Excedrin, Ranitidine)
    I've been going to my Suboxone doctor for over a year now. In that time all I have done (as far as "narcotic" go) is my Suboxone and when my grandpa passed she wrote me a small script, on 2 different occasion for Xanax 0.5 (which I was actually able to hold onto until about a month ago..) Well, yest ...
  • Anybody else can't lay on their back to sleep? (1 answer)
    (Asked by a 60 year old woman who has Relapsing-remitting Multiple Sclerosis, Degenerative Disc Disease, Arthritis, and takes Tramadol, Rebif, Celebrex, Soma, Gabapentin, Lisinopril And Hydrochlorothiazide)
    Laying on my back causes severe pain and muscle spasms. Does anyone have a possible solution?

More questions for: Zestoretic

You may be interested at these reviews (Write a review):

  • Teatical adnoma was told i had testicular cancer until doctor said i did not
    (Posted by a 48 year old man who has Testicle Lump, Testicular Pain, and takes Lisinopril And Hydrochlorothiazide)
    I was told by a Doctor that I had Testicula cancer and he set up surgery right away. I was preped and ready to go into the surgery room and I had to ask my surgen a quick question regarding the surgery he called it an orchietomy and I asked him so you are going to cut me open and remove the Tumor ? ...
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    I started taking Cymbalta in August for pain. By September I was suffering from shortness of breath. Visited Doctors asking if Cymbalta could be the cause. Answer was no. By the end of September I was no longer taking Cymbalta but still suffering from shortness of breath. It was getting severe a ...

More reviews for: Zestoretic

On eHealthMe, Zestoretic (hydrochlorothiazide; lisinopril) is often used for high blood pressure. Find out below the conditions Zestoretic is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Zestoretic used for and how effective is it:

Other drugs that are used to treat the same conditions:

Studies of common Zestoretic drug interactions:

Browse Zestoretic drug interactions with drugs from A to Z:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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