Pain in extremity and Macule


Macule is found among people with Pain in extremity, especially for people who are female, 60+ old.

The study analyzes which people have Macule with Pain in extremity. It is created by eHealthMe based on reports of 6 people who have Pain in extremity from the Food and Drug Administration (FDA), and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 17, 2022

6 people who have Pain In Extremity and Macule are studied.

What is Pain in extremity?

Pain in extremity is found to be associated with 4,220 drugs and 3,928 conditions by eHealthMe.

What is Macule?

Macule (a discoloured spot on the skin) is found to be associated with 953 drugs and 612 conditions by eHealthMe.

Number of Macule in Pain in extremity reports submitted per year:

Would you have Macule when you have Pain in extremity?

Gender of people who have Pain In Extremity and experienced Macule *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Pain In Extremity and experienced Macule *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 16.67 %
  • 50-59: 0.0 %
  • 60+: 83.33 %

Common co-existing conditions for these people *:

  1. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 5 people, 83.33%
  2. Urination - Excessive Volume: 4 people, 66.67%
  3. Thyroid Diseases: 4 people, 66.67%
  4. Sleep Disorder: 4 people, 66.67%
  5. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 66.67%
  6. Pain: 4 people, 66.67%
  7. High Blood Pressure: 4 people, 66.67%
  8. Spinal Osteoarthritis (joint cartilage loss in spine): 1 person, 16.67%
  9. Rash Pruritic (redness with itching): 1 person, 16.67%
  10. Joint Pain: 1 person, 16.67%

Common drugs taken by these people *:

  1. Xeljanz Xr: 4 people, 66.67%
  2. Vitamin D3: 4 people, 66.67%
  3. Melatonin: 4 people, 66.67%
  4. Baby Aspirin: 4 people, 66.67%
  5. Aleve: 4 people, 66.67%
  6. Advil Liqui-Gels: 4 people, 66.67%
  7. Advil: 3 people, 50.00%
  8. Xyzal: 1 person, 16.67%
  9. Plavix: 1 person, 16.67%
  10. Maxzide: 1 person, 16.67%

Common symptoms for these people *:

  1. Weight Increased: 4 people, 66.67%
  2. Headache (pain in head): 4 people, 66.67%
  3. Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 4 people, 66.67%
  4. Skin Discoloration: 4 people, 66.67%
  5. Fungal Skin Infection: 4 people, 66.67%
  6. Renal Impairment (severely reduced kidney function): 2 people, 33.33%
  7. Nasopharyngitis (inflammation of the nasopharynx): 2 people, 33.33%
  8. Malaise (a feeling of general discomfort or uneasiness): 2 people, 33.33%
  9. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 1 person, 16.67%
  10. Confusional State: 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take medications and have Macule?

Check whether Macule is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Treatments, associated drugs and conditions:

COVID vaccines that are related to Macule:

Common drugs associated with Macule:

All the drugs that are associated with Macule:

Common conditions associated with Macule:

All the conditions that are associated with Macule:

How the study uses the data?

The study is based on Macule and Pain in extremity, and their synonyms.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: