Acetaminophen and Ibuprofen drug interactions - from FDA reports


Drug interactions are reported among people who take Acetaminophen and Ibuprofen together. This review analyzes the effectiveness and drug interactions between Acetaminophen and Ibuprofen. It is created by eHealthMe based on reports of 5,511 people who take the same drugs from FDA , and is updated regularly.



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On Jun, 03, 2018

5,511 people who take Acetaminophen, Ibuprofen are studied.


Number of reports submitted per year:

Acetaminophen and Ibuprofen drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Vomiting
  2. Renal failure acute (rapid kidney dysfunction)
  3. Diarrhoea
  4. Pyrexia (fever)
  5. Suicide attempt
1 - 6 months:
  1. Nausea (feeling of having an urge to vomit)
  2. Speech disorder
  3. General physical health deterioration (weak health status)
  4. Insomnia (sleeplessness)
  5. Malaise (a feeling of general discomfort or uneasiness)
6 - 12 months:
  1. Renal failure acute (rapid kidney dysfunction)
  2. Renal impairment (severely reduced kidney function)
  3. Disease progression
  4. Lung adenocarcinoma (a form of non-small cell lung cancer)
  5. Renal failure (kidney dysfunction)
1 - 2 years:
  1. Anaemia (lack of blood)
  2. Haemorrhage (bleeding)
  3. Hypoaesthesia (reduced sense of touch or sensation)
  4. International normalised ratio increased
  5. Paraplegia (paralysis of the legs and lower body)
2 - 5 years:
  1. Dyspnoea (difficult or laboured respiration)
  2. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  3. Oedema peripheral (superficial swelling)
  4. Pulmonary embolism (blockage of the main artery of the lung)
  5. Anxiety
5 - 10 years:
  1. Gallbladder disorder
  2. Injury
  3. Loss of consciousness
  4. Pyrexia (fever)
  5. Renal failure (kidney dysfunction)
10+ years:
  1. Injury
  2. Abdominal pain
  3. Nausea (feeling of having an urge to vomit)
  4. Pulmonary embolism (blockage of the main artery of the lung)
  5. Dyspnoea (difficult or laboured respiration)
not specified:
  1. Nausea (feeling of having an urge to vomit)
  2. Anxiety
  3. Vomiting
  4. Completed suicide (act of taking one's own life)
  5. Pyrexia (fever)
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Most common drug interactions by gender *:

female:
  1. Pyrexia (fever)
  2. Pulmonary embolism (blockage of the main artery of the lung)
  3. Depression
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Asthenia (weakness)
male:
  1. Pyrexia (fever)
  2. Vomiting
  3. Diarrhoea
  4. Dizziness
  5. Asthenia (weakness)
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Most common drug interactions by age *:

0-1:
  1. Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
  2. Dehydration (dryness resulting from the removal of water)
  3. Decreased appetite
  4. Pyrexia (fever)
  5. Somnolence (a state of near-sleep, a strong desire for sleep)
2-9:
  1. Renal papillary necrosis (a disorder of the kidneys in which all or part of the renal papillae die)
  2. Renal failure acute (rapid kidney dysfunction)
  3. Ureteric obstruction
  4. Vomiting
  5. Renal failure (kidney dysfunction)
10-19:
  1. Vomiting
  2. Nausea (feeling of having an urge to vomit)
  3. Completed suicide (act of taking one's own life)
  4. Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  5. Abdominal pain
20-29:
  1. Completed suicide (act of taking one's own life)
  2. Acute hepatic failure
  3. Vomiting
  4. Hepatic necrosis (large portions of liver die off due to severe liver disease)
  5. Hepatic failure (liver failure)
30-39:
  1. Completed suicide (act of taking one's own life)
  2. Nausea (feeling of having an urge to vomit)
  3. Anxiety
  4. Pulmonary embolism (blockage of the main artery of the lung)
  5. Pyrexia (fever)
40-49:
  1. Nausea (feeling of having an urge to vomit)
  2. Anxiety
  3. Fatigue (feeling of tiredness)
  4. Completed suicide (act of taking one's own life)
  5. Pyrexia (fever)
50-59:
  1. Anxiety
  2. Depression
  3. Completed suicide (act of taking one's own life)
  4. Pyrexia (fever)
  5. Back pain
60+:
  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Urinary tract infection
  3. Anxiety
  4. Dizziness
  5. Pneumonia
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* Approximation only. Some reports may have incomplete information.

What's next:

Do you take Acetaminophen with Ibuprofen?



Related studies

Acetaminophen

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Acetaminophen 76,319 users)

Ibuprofen

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from Ibuprofen 107,282 users)


Interactions between Acetaminophen and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Ibuprofen and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Acetaminophen and Ibuprofen
a b c d e f g h i j k l m n o p q r s t u v w x y z

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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