Anaprox and Tramadol drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among people who take Anaprox and Tramadol. Common interactions include arthropathy among females and hallucination among males.

The phase IV clinical study analyzes what interactions people who take Anaprox and Tramadol have. It is created by eHealthMe based on reports of 96 people who take Anaprox and Tramadol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 24, 2022

96 people who take Anaprox and Tramadol together, and have interactions are studied.

What is Anaprox?

Anaprox has active ingredients of naproxen sodium. eHealthMe is studying from 1,316 Anaprox users for its effectiveness, alternative drugs and more.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 200,042 Tramadol users for its effectiveness, alternative drugs and more.

Number of Anaprox and Tramadol reports submitted per year:

Anaprox and Tramadol drug interactions.

Common Anaprox and Tramadol drug interactions by gender *:


  1. Arthropathy
  2. Intervertebral disc protrusion
  3. Autoimmune disorder
  4. Chest pain
  5. Cognitive disorder
  6. Connective tissue disorder
  7. Ear disorder
  8. Fall
  9. Headache
  10. Inflammation


  1. Hallucination
  2. Asthenia
  3. Chest discomfort
  4. Chest pain
  5. Deafness
  6. Diabetes mellitus
  7. Dizziness
  8. Drug toxicity
  9. Headache
  10. Loss of consciousness

Common Anaprox and Tramadol drug interactions by age *:






  1. Application site discomfort
  2. Implant site pain


  1. Acute myeloid leukaemia
  2. Blood bilirubin increased


  1. Acute myocardial infarction
  2. Angina unstable
  3. Anxiety
  4. Chest pain
  5. Cough
  6. Depression
  7. Hypomagnesaemia
  8. Musculoskeletal discomfort
  9. Abnormal behaviour
  10. Cardiac enzymes increased


  1. Muscle spasms
  2. Night sweats
  3. Osteoarthritis
  4. Otorrhoea
  5. Palpitations
  6. Pancytopenia
  7. Raynaud's phenomenon
  8. Sinusitis
  9. Staphylococcal infection
  10. Swollen tongue


  1. Somnolence
  2. Drug hypersensitivity
  3. Stress cardiomyopathy
  4. Blood pressure increased
  5. Ear disorder
  6. Chronic kidney disease
  7. Foot fracture
  8. Nausea
  9. Abscess rupture
  10. Arthralgia


  1. Fall
  2. Asthenia
  3. Arthralgia
  4. Blood glucose decreased
  5. Concussion
  6. Depression
  7. Dizziness
  8. Dysstasia
  9. Fatigue
  10. Febrile neutropenia

Common conditions people have *:

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 37 people, 38.54%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 12.50%
  3. Hepatitis C: 10 people, 10.42%
  4. Muscle Spasms (muscle contraction): 8 people, 8.33%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 8.33%
  6. Depression: 8 people, 8.33%
  7. Back Pain: 8 people, 8.33%
  8. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 7 people, 7.29%
  9. Neuropathy Peripheral (surface nerve damage): 7 people, 7.29%
  10. Stress And Anxiety: 6 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Anaprox and Tramadol?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Common Anaprox and Tramadol interactions:

Browse all drug interactions of Anaprox and Tramadol:

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Common Anaprox interactions:

Browse all interactions between Anaprox and drugs from A to Z:

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Common Tramadol interactions:

Browse all interactions between Tramadol and drugs from A to Z:

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How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium and tramadol hydrochloride (the active ingredients of Anaprox and Tramadol, respectively), and Anaprox and Tramadol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Anaprox and Tramadol.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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