Arava and Tagamet drug interactions - from FDA reports


Drug interactions are reported among people who take Arava and Tagamet together. This study is created by eHealthMe based on reports of 36 people who take Arava and Tagamet from FDA, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on leflunomide and cimetidine (the active ingredients of Arava and Tagamet, respectively), and Arava and Tagamet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. (latest outcomes from Arava 34,016 users)

What is Tagamet?

Tagamet has active ingredients of cimetidine. It is often used in gastroesophageal reflux disease. (latest outcomes from Tagamet 7,115 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Feb, 24, 2019

36 people who take Arava, Tagamet are studied.

Number of reports submitted per year:

Arava and Tagamet drug interactions.

Most common drug interactions over time *:

6 - 12 months:


1 - 2 years:


2 - 5 years:
  1. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  2. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  3. Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
  4. Ascites (accumulation of fluid in the abdominal cavity)
  5. Dehydration (dryness resulting from the removal of water)
  6. Diarrhoea
  7. Hepatorenal syndrome (renal failure in patients with advanced chronic liver disease)
  8. Joint dislocation (a joint position is changed from normal position)
  9. Renal failure acute (rapid kidney dysfunction)
  10. Vomiting
5 - 10 years:


10+ years:


not specified:
  1. Cataract (clouding of the lens inside the eye)
  2. Condition
  3. Diarrhoea
  4. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  5. Haemoglobin decreased
  6. Interstitial lung disease
  7. Mitral valve incompetence (inefficient heart valve)
  8. Nausea (feeling of having an urge to vomit)
  9. Pleural effusion (water on the lungs)
  10. Pulmonary oedema (fluid accumulation in the lungs)

Most common drug interactions by gender *:

  1. Abdominal distension
  2. Abdominal pain upper
  3. Arthralgia (joint pain)
  4. Choking (mechanical obstruction of the flow of air from the environment into the lungs)
  5. Diarrhoea
  6. Interstitial lung disease
  7. Joint dislocation (a joint position is changed from normal position)
  8. Joint stiffness
  9. Vomiting

Most common drug interactions by age *:









  1. Diarrhoea
  2. Haemorrhagic ovarian cyst (bleeding ovarian cyst)
  3. Pruritus (severe itching of the skin)
  4. Alanine aminotransferase increased
  5. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  6. Aspartate aminotransferase increased
  7. Blood alkaline phosphatase increased
  8. Blood lactate dehydrogenase increased
  9. Calculus ureteric (stone in ureter)
  10. Nausea (feeling of having an urge to vomit)
  1. Haemoglobin decreased
  2. Hypertension (high blood pressure)
  3. Hypertensive crisis
  4. Lymphocyte percentage decreased
  5. Monocyte percentage decreased
  6. Monocyte percentage increased
  7. Nasopharyngitis (inflammation of the nasopharynx)
  8. Nausea (feeling of having an urge to vomit)
  9. Pulmonary hypertension primary (increase in blood pressure in the lung artery with no cause)
  10. Pyrexia (fever)
  1. Blood alkaline phosphatase increased
  2. Gamma-glutamyltransferase increased
  3. Pancreatitis (inflammation of pancreas)
  4. Anxiety
  5. Blood bilirubin increased
  6. Cardiac failure congestive
  7. Cardiomyopathy (weakening of the heart muscle)
  8. Cataract (clouding of the lens inside the eye)
  9. Cerebral infarction (less blood supply to brain resulting tissue damage)
  10. Condition

* Approximation only. Some reports may have incomplete information.

Do you take Arava and Tagamet?

You are not alone:

Related studies

Browse interactions by gender and age

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Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Interactions between Arava and drugs from A to Z
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Interactions between Tagamet and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Arava and Tagamet
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What would happen?

Predict new side effects and undetected conditions when you take Arava and Tagamet

FDA reports used in this study

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