Arava and Tagamet drug interactions - from FDA reports

Drug interactions are reported among people who take Arava and Tagamet together. This study is created by eHealthMe based on reports of 36 people who take Arava and Tagamet from FDA, and is updated regularly.

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On Jan, 12, 2019

36 people who take Arava, Tagamet are studied.

Number of reports submitted per year:

Arava and Tagamet drug interactions.

Most common drug interactions over time *:

1 - 6 months:
  1. Gamma-glutamyltransferase increased
  2. Alanine aminotransferase increased
  3. Aspergillosis (an infection caused by a fungus called aspergillus)
  4. Blood potassium decreased
  5. Cholecystitis infective (infection of gallbladder capable to infect other organs)
  6. Hospitalisation
  7. Interstitial lung disease
  8. Pancreatitis (inflammation of pancreas)
  9. Blood bilirubin increased
  10. Drug level increased
6 - 12 months:


1 - 2 years:


2 - 5 years:
  1. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  2. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  3. Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
  4. Ascites (accumulation of fluid in the abdominal cavity)
  5. Dehydration (dryness resulting from the removal of water)
  6. Hepatorenal syndrome (renal failure in patients with advanced chronic liver disease)
  7. Renal failure acute (rapid kidney dysfunction)
5 - 10 years:


10+ years:


not specified:
  1. Cataract (clouding of the lens inside the eye)
  2. Haemoglobin decreased
  3. Interstitial lung disease
  4. Mitral valve incompetence (inefficient heart valve)
  5. Nausea (feeling of having an urge to vomit)
  6. Pleural effusion (water on the lungs)
  7. Weakness
  8. Aspergillosis (an infection caused by a fungus called aspergillus)
  9. Blood bilirubin increased
  10. Cholecystitis infective (infection of gallbladder capable to infect other organs)

Most common drug interactions by gender *:

  1. Abdominal distension
  2. Abdominal pain upper
  3. Arthralgia (joint pain)
  4. Choking (mechanical obstruction of the flow of air from the environment into the lungs)
  5. Interstitial lung disease
  6. Joint stiffness

Most common drug interactions by age *:









  1. Diarrhoea
  2. Haemorrhagic ovarian cyst (bleeding ovarian cyst)
  3. Pruritus (severe itching of the skin)
  4. Alanine aminotransferase increased
  5. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  6. Aspartate aminotransferase increased
  7. Blood alkaline phosphatase increased
  8. Blood lactate dehydrogenase increased
  9. Calculus ureteric (stone in ureter)
  10. Hepatic function abnormal
  1. Blood potassium decreased
  2. Cyst (a closed sac)
  3. Drug ineffective
  4. Haematocrit decreased
  5. Haemoglobin decreased
  6. Hysterosalpingo-oophorectomy
  7. Neoplasm (tumour)
  8. Postoperative haematoma (localized collection of blood outside the blood vessels after post-operative)
  9. Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues)
  10. Abdominal wall infection

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study

Do you take Arava and Tagamet?

You are not alone:

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Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. (latest outcomes from Arava 34,016 users)


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Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Interactions between Arava and drugs from A to Z
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Interactions between Tagamet and drugs from A to Z
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What would happen?

Predict new side effects and undetected conditions when you take Arava and Tagamet

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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