Aspirin and Metformin drug interactions - from FDA reports


Drug interactions are reported among people who take Aspirin and Metformin together. This study is created by eHealthMe based on reports of 36,455 people who take Aspirin and Metformin from FDA, and is updated regularly.

How to use this study: bring a copy to your health teams to ensure drug risks and benefits are fully discussed and understood.


Peer to Peer mobile support

Peer support for this study is available on our Ginger Health app. It's free, anonymous and secure. The app is ideal for people taking multiple medications or having multiple conditions.



On Jan, 23, 2019

36,455 people who take Aspirin, Metformin are studied.


Number of reports submitted per year:

Aspirin and Metformin drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Diarrhoea
  2. Nausea (feeling of having an urge to vomit)
  3. Back pain
  4. Vomiting
  5. Condition
  6. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  7. Constipation
  8. Electrolyte imbalance
  9. Hyperthyroidism (over activity of the thyroid gland)
  10. Abdominal pain
1 - 6 months:
  1. Back pain
  2. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  3. Malaise (a feeling of general discomfort or uneasiness)
  4. Asthenia (weakness)
  5. Nausea (feeling of having an urge to vomit)
  6. Renal impairment (severely reduced kidney function)
  7. Renal failure acute (rapid kidney dysfunction)
  8. Pain
  9. Blood glucose increased
  10. Confusional state
6 - 12 months:
  1. Hypoglycaemia (deficiency of glucose in the bloodstream)
  2. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
  3. Lactic acidosis (low ph in body tissues)
  4. Skin ulcer
  5. Renal failure acute (rapid kidney dysfunction)
  6. Cellulitis (infection under the skin)
  7. Chronic kidney disease
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Small intestinal obstruction (blockage in small intestine)
  10. Fatigue (feeling of tiredness)
1 - 2 years:
  1. Renal failure acute (rapid kidney dysfunction)
  2. Nausea (feeling of having an urge to vomit)
  3. Weight decreased
  4. Hypoglycaemia (deficiency of glucose in the bloodstream)
  5. Respiratory failure (inadequate gas exchange by the respiratory system)
  6. Lactic acidosis (low ph in body tissues)
  7. Cellulitis (infection under the skin)
  8. Sepsis (a severe blood infection that can lead to organ failure and death)
  9. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  10. Renal failure (kidney dysfunction)
2 - 5 years:
  1. Dehydration (dryness resulting from the removal of water)
  2. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  3. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  4. Lactic acidosis (low ph in body tissues)
  5. Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
  6. Chronic kidney disease
  7. Diarrhoea
  8. Renal failure acute (rapid kidney dysfunction)
  9. Renal failure (kidney dysfunction)
  10. Vomiting
5 - 10 years:
  1. Constipation
  2. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  3. Chronic kidney disease
  4. Back pain
  5. Urinary tract infection
  6. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  7. Nausea (feeling of having an urge to vomit)
  8. Sepsis (a severe blood infection that can lead to organ failure and death)
  9. Abdominal pain
  10. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
10+ years:
  1. Diarrhoea
  2. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  3. Pyrexia (fever)
  4. Haematemesis (vomiting of blood)
  5. Renal failure (kidney dysfunction)
  6. Vomiting
  7. Acute myocardial infarction (acute heart attack)
  8. Dehydration (dryness resulting from the removal of water)
  9. Pneumonia
  10. Fall
not specified:
  1. Nausea (feeling of having an urge to vomit)
  2. Fatigue (feeling of tiredness)
  3. Dyspnoea (difficult or laboured respiration)
  4. Diarrhoea
  5. Blood glucose increased
  6. Dizziness
  7. Drug ineffective
  8. Vomiting
  9. Pain
  10. Weight decreased

Most common drug interactions by gender *:

female:
  1. Weight decreased
  2. Asthenia (weakness)
  3. Pain in extremity
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Arthralgia (joint pain)
  6. Pneumonia
  7. Cough
  8. Chest pain
  9. Back pain
  10. Anaemia (lack of blood)
male:
  1. Dyspnoea (difficult or laboured respiration)
  2. Fatigue (feeling of tiredness)
  3. Pain
  4. Pneumonia
  5. Fall
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Headache (pain in head)
  8. Chest pain
  9. Hypotension (abnormally low blood pressure)
  10. Decreased appetite

Most common drug interactions by age *:

0-1:
  1. Premature baby
  2. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
  3. Hypoglycaemia neonatal (deficiency of glucose in the bloodstream in neonatal)
  4. Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
  5. Nausea (feeling of having an urge to vomit)
  6. Congenital teratoma (big tumour by birth)
  7. Conjunctival haemorrhage (bleeding underneath the conjunctiva)
  8. Cryptorchism
  9. Facial paresis (weakness in facial muscle movement)
  10. Foetal cerebrovascular disorder (a group of brain dysfunctions related to disease of the blood vessels supplying the brain of foetus)
2-9:
  1. Chest pain
  2. Haemoglobin decreased
  3. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
  4. Vomiting
  5. Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
  6. Alanine aminotransferase increased
  7. Aspartate aminotransferase increased
  8. Bacterial infection
  9. Blood amylase increased
  10. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
10-19:
  1. Hypotension (abnormally low blood pressure)
  2. Acidosis (build-up of carbon dioxide in the blood)
  3. Hypoglycaemia (deficiency of glucose in the bloodstream)
  4. Hyperlactacidaemia (the acidosis and also reduces the capacity of the kidney)
  5. Chronic kidney disease
  6. Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
  7. Mucosal inflammation (infection of mucous membrane)
  8. Oral candidiasis (fungal infection of mouth)
  9. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  10. Small intestinal obstruction (blockage in small intestine)
20-29:
  1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  2. Abdominal pain
  3. Nausea (feeling of having an urge to vomit)
  4. Fatigue (feeling of tiredness)
  5. Hyperglycaemia (high blood sugar)
  6. Vision blurred
  7. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  8. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  9. Vomiting
  10. Confusional state
30-39:
  1. Fatigue (feeling of tiredness)
  2. Headache (pain in head)
  3. Pain
  4. Vomiting
  5. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  6. Abdominal pain
  7. Nausea (feeling of having an urge to vomit)
  8. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  9. Diarrhoea
  10. Dehydration (dryness resulting from the removal of water)
40-49:
  1. Nausea (feeling of having an urge to vomit)
  2. Pain
  3. Fatigue (feeling of tiredness)
  4. Diarrhoea
  5. Dizziness
  6. Dyspnoea (difficult or laboured respiration)
  7. Vomiting
  8. Blood glucose increased
  9. Chest pain
  10. Headache (pain in head)
50-59:
  1. Weight decreased
  2. Malaise (a feeling of general discomfort or uneasiness)
  3. Chest pain
  4. Arthralgia (joint pain)
  5. Pain in extremity
  6. Renal failure acute (rapid kidney dysfunction)
  7. Asthenia (weakness)
  8. Fall
  9. Pyrexia (fever)
  10. Anxiety
60+:
  1. Nausea (feeling of having an urge to vomit)
  2. Dyspnoea (difficult or laboured respiration)
  3. Fall
  4. Pain
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Pneumonia
  7. Renal failure acute (rapid kidney dysfunction)
  8. Pain in extremity
  9. Headache (pain in head)
  10. Decreased appetite

* Approximation only. Some reports may have incomplete information.

Do you take Aspirin and Metformin?


You are not alone:




Related studies

Aspirin

Aspirin has active ingredients of aspirin. It is often used in blood clots. (latest outcomes from Aspirin 385,580 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 259,096 users)


Browse by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Aspirin and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Metformin and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Aspirin and Metformin
a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

What would happen?

Predict new side effects and undetected conditions when you take Aspirin and Metformin (101,847 reports studied)

FDA reports used in this study



Recent updates

Recent general studies
Recent personal studies

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Submit your testimonial

  • Please fill in your Testimonial.
  • Please enter a minimum of 10 characters for your Testimonial.
  • Please fill in your Name.

Please wait...

{progressItem}

Thank you!