Aspirin and Protonix drug interactions - from FDA reports

Drug interactions are reported among people who take Aspirin and Protonix together. This study is created by eHealthMe based on reports of 8,557 people who take Aspirin and Protonix from FDA, and is updated regularly.

Who is eHealthMe: we are a data analysis company who specializes in health care industry. Our independent and original studies have been referenced on 400+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and EANO.

On Aug, 15, 2018

8,557 people who take Aspirin, Protonix are studied.

Number of reports submitted per year:

Aspirin and Protonix drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Nausea (feeling of having an urge to vomit)
  2. Anaemia (lack of blood)
  3. Pain
  4. Pneumonia
  5. Multi-organ failure (multisystem organ failure)
  6. Renal failure (kidney dysfunction)
  7. Anxiety
  8. Depression
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Injury
1 - 6 months:
  1. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  2. Nausea (feeling of having an urge to vomit)
  3. Asthenia (weakness)
  4. Decreased appetite
  5. Syncope (loss of consciousness with an inability to maintain postural tone)
  6. Cerebral haemorrhage (bleeding within the brain)
  7. Pain
  8. Abdominal discomfort
  9. Abdominal pain
  10. Anaemia (lack of blood)
6 - 12 months:
  1. Osteoporosis (bones weak and more likely to break)
  2. Spinal fracture (fracture in one of vertebrae)
  3. Bone density decreased
  4. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  5. Spinal compression fracture (fracture due to spinal compression on bone)
  6. Cubital tunnel syndrome (a condition brought on by increased pressure on the ulnar nerve at the elbow)
  7. Epicondylitis (tennis elbow)
  8. Ligament sprain (ligament stretched)
  9. Hepatic steatosis (fatty liver disease)
  10. Arthralgia (joint pain)
1 - 2 years:
  1. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  2. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  3. Arthralgia (joint pain)
  4. Asthenia (weakness)
  5. Cellulitis (infection under the skin)
  6. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  7. Localised infection (infection at the single location)
  8. Pain
  9. Peripheral ischaemia (impaired circulation to an extremity)
  10. Rectal haemorrhage (bleeding from anus)
2 - 5 years:
  1. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  2. Anxiety
  3. Depression
  4. Pain
  5. Angina pectoris (chest pain due to ischemia of the heart muscle)
  6. Bone disorder
  7. Fall
  8. Renal failure (kidney dysfunction)
  9. Anaemia (lack of blood)
  10. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
5 - 10 years:
  1. Muscle atrophy (a decrease in the mass of the muscle)
  2. Oesophageal achalasia (difficulty swallowing, food sticking in the oesophagus)
  3. Oesophageal ulcer (ulcer of oesophagus)
  4. Pain
  5. Pancreatitis (inflammation of pancreas)
  6. Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
  7. Pruritus generalised (generalized itching)
  8. Rash
  9. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  10. Skin cancer
10+ years:
  1. Constipation
  2. Intestinal obstruction
  3. Multi-organ failure (multisystem organ failure)
  4. Neutropenia (an abnormally low number of neutrophils)
  5. Pneumonia
  6. Subdural haematoma (blood collects between the skull and the surface of the brain)
  7. Anaemia (lack of blood)
  8. Ankle fracture
  9. Arteriosclerosis (thickening and hardening of arteries)
  10. Bladder disorder
not specified:
  1. Pain
  2. Dyspnoea (difficult or laboured respiration)
  3. Nausea (feeling of having an urge to vomit)
  4. Fatigue (feeling of tiredness)
  5. Anxiety
  6. Diarrhoea
  7. Anaemia (lack of blood)
  8. Asthenia (weakness)
  9. Pneumonia
  10. Chest pain
Personalize this study to your gender and age

Most common drug interactions by gender *:

  1. Diarrhoea
  2. Anxiety
  3. Asthenia (weakness)
  4. Fall
  5. Dizziness
  6. Vomiting
  7. Chest pain
  8. Pneumonia
  9. Anaemia (lack of blood)
  10. Arthralgia (joint pain)
  1. Dyspnoea (difficult or laboured respiration)
  2. Pain
  3. Injury
  4. Diarrhoea
  5. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  6. Dizziness
  7. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  8. Fall
  9. Oedema peripheral (superficial swelling)
  10. Vomiting
Subscribe to monitor Aspirin and Protonix

Most common drug interactions by age *:

  1. Cough
  2. Crying
  3. Heart disease congenital
  4. Irritability
  5. Multimorbidity (co-occurrence of two or more chronic medical conditions in one person)
  6. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  7. Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
  8. Septic shock (shock due to blood infection)
  9. Transplant failure (transplantation failed to meet outcome)
  10. Vomiting
  1. Abasia (inability to walk)
  2. Arthralgia (joint pain)
  3. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
  4. Cardiac disorder
  5. Cataract (clouding of the lens inside the eye)
  6. Femur fracture
  7. Fibromyalgia (a long-term condition which causes pain all over the body)
  8. Fracture
  9. Pain
  10. Pain in extremity
  1. Crohn's disease (condition that causes inflammation of the gastrointestinal tract)
  2. Pneumonia
  3. Abdominal pain upper
  4. Deafness unilateral
  5. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  6. Fatigue (feeling of tiredness)
  7. Hypotension (abnormally low blood pressure)
  8. Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
  9. Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
  10. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  1. Pneumonia
  2. Cardiomegaly (increased size of heart than normal)
  3. Nausea (feeling of having an urge to vomit)
  4. Anxiety
  5. Dyspnoea (difficult or laboured respiration)
  6. Cardiac failure congestive
  7. Urinary tract infection
  8. Vomiting
  9. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  10. Pain
  1. Pain
  2. Anxiety
  3. Nausea (feeling of having an urge to vomit)
  4. Vomiting
  5. Chest pain
  6. Dyspnoea (difficult or laboured respiration)
  7. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  8. Pain in extremity
  9. Depression
  10. Injury
  1. Pain
  2. Chest pain
  3. Nausea (feeling of having an urge to vomit)
  4. Anxiety
  5. Dyspnoea (difficult or laboured respiration)
  6. Dizziness
  7. Diarrhoea
  8. Fatigue (feeling of tiredness)
  9. Vomiting
  10. Depression
  1. Pain
  2. Nausea (feeling of having an urge to vomit)
  3. Fatigue (feeling of tiredness)
  4. Diarrhoea
  5. Anxiety
  6. Dyspnoea (difficult or laboured respiration)
  7. Anaemia (lack of blood)
  8. Arthralgia (joint pain)
  9. Hypotension (abnormally low blood pressure)
  10. Headache (pain in head)
  1. Asthenia (weakness)
  2. Fatigue (feeling of tiredness)
  3. Anaemia (lack of blood)
  4. Pneumonia
  5. Diarrhoea
  6. Fall
  7. Dizziness
  8. Chest pain
  9. Cardiac failure congestive
  10. Anxiety
Click here to get more results

* Approximation only. Some reports may have incomplete information.

Are you new to Aspirin and Protonix or have questions?

Volunteer or get paid to help people with your care experience

Related studies


Aspirin has active ingredients of aspirin. It is often used in blood clots. (latest outcomes from Aspirin 317,745 users)


Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. (latest outcomes from Protonix 55,375 users)

Interactions between Aspirin and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Protonix and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Aspirin and Protonix
a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

What would happen?

Predict new side effects and undetected conditions when you take Aspirin and Protonix (73,803 reports studied)

You are not alone. Join our personalized support groups:

You may be interested in these posts

More posts for: Aspirin, Protonix

Recent updates

General studies

You could also:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.