Bactrim and Zoloft drug interactions - from FDA reports

Drug interactions are reported among people who take Bactrim and Zoloft together. This study is created by eHealthMe based on reports of 1,119 people who take Bactrim and Zoloft from FDA, and is updated regularly.

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On Dec, 21, 2018

1,119 people who take Bactrim, Zoloft are studied.

Number of reports submitted per year:

Bactrim and Zoloft drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Nausea (feeling of having an urge to vomit)
  2. Fatigue (feeling of tiredness)
  3. Asthenia (weakness)
  4. Chest pain
  5. Drug hypersensitivity
  6. Renal failure (kidney dysfunction)
  7. Headache (pain in head)
  8. Pain
  9. Dizziness
  10. General physical health deterioration (weak health status)
1 - 6 months:
  1. Agitation (state of anxiety or nervous excitement)
  2. Anaemia (lack of blood)
  3. Aspartate aminotransferase increased
  4. Blood bilirubin increased
  5. Decreased appetite
  6. Febrile neutropenia (fever with reduced white blood cells)
  7. Hypokalaemia (low potassium)
  8. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
  9. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  10. Hypotension (abnormally low blood pressure)
6 - 12 months:
  1. Abscess (pus)
  2. Bone disorder
  3. Fistula (an abnormal connection or passageway between two)
  4. Heart transplant
  5. Hypoaesthesia (reduced sense of touch or sensation)
  6. Incisional drainage
  7. Maternal exposure during pregnancy (use of substance during pregnancy)
  8. Oral surgery
  9. Osteomyelitis (infection of bone)
  10. Osteonecrosis (death of bone)
1 - 2 years:
  1. Nausea (feeling of having an urge to vomit)
  2. Calcinosis (calcium deposits in any soft tissue)
  3. Cardiac failure
  4. Coma (state of unconsciousness lasting more than six hours)
  5. Drug hypersensitivity
  6. Electroencephalogram abnormal
  7. Hearing impaired
  8. Hypertension (high blood pressure)
  9. Overdose
  10. Vertigo
2 - 5 years:
  1. Hot flush (sudden feelings of heat)
  2. Hyperhidrosis (abnormally increased sweating)
  3. Injury
  4. Laceration (tearing of soft body tissue)
  5. Lipase increased
  6. Loss of consciousness
  7. Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Mania (a state of abnormally elevated or irritable mood)
  10. Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
5 - 10 years:
  1. Foot fracture
  2. Lower limb fracture
  3. Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
  4. Abnormal behaviour
  5. Abortion spontaneous (naturally occurring miscarriage)
  6. Bladder disorder
  7. Cardiac disorder
  8. Congenital anomaly (birth defect)
  9. Craniosynostosis (a baby is born with an abnormally shaped skull or develops one during growth)
  10. Developmental delay
10+ years:
  1. Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
  2. Cleft palate (birth defect (congenital) of the upper part of the mouth)
  3. Congenital cardiovascular anomaly (birth defect of heart vessels)
  4. Ear infection
  5. Heart disease congenital
  6. Limb malformation (abnormal birth defect of leg)
  7. Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
  8. Patent ductus arteriosus (condition in which the ductus arteriosus does not close)
  9. Skull malformation (abnormal skull structure)
not specified:
  1. Pain
  2. Nausea (feeling of having an urge to vomit)
  3. Back pain
  4. Fatigue (feeling of tiredness)
  5. Pyrexia (fever)
  6. Headache (pain in head)
  7. Pain in extremity
  8. Weight decreased
  9. Anaemia (lack of blood)
  10. Vomiting

Most common drug interactions by gender *:

  1. Fatigue (feeling of tiredness)
  2. Pain in extremity
  3. Vomiting
  4. Drug hypersensitivity
  5. Headache (pain in head)
  6. Anaemia (lack of blood)
  7. Pyrexia (fever)
  8. Oedema peripheral (superficial swelling)
  9. Insomnia (sleeplessness)
  10. Fall
  1. Pain
  2. Weight decreased
  3. Impaired healing
  4. Bone disorder
  5. Cellulitis (infection under the skin)
  6. Drug abuse
  7. Dyspnoea (difficult or laboured respiration)
  8. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  9. Chest pain
  10. Neuralgia (pain in one or more nerves)

Most common drug interactions by age *:

  1. Congenital nail disorder (nail disease by birth)
  2. Nipple disorder (disease of nipple)
  3. Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues)
  4. Facial dysmorphism (an anatomical malformation of face)
  5. Fever neonatal
  6. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
  7. Hydrocephalus (water on the brain)
  8. Hypotonia neonatal (low muscle tone in neonatal)
  9. Low birth weight baby
  10. Maternal drugs affecting foetus (chemical affecting the baby before birth taken by mother)
  1. Dyspnoea (difficult or laboured respiration)
  2. Hypertension (high blood pressure)
  3. Urinary incontinence (inability to control the flow of urine and involuntary urination)
  4. Abdominal distension
  5. Abdominal pain
  6. Abnormal behaviour
  7. Acrochordon (small, soft, common, benign skin tag)
  8. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  9. Anaemia (lack of blood)
  10. Animal bite
  1. Nausea (feeling of having an urge to vomit)
  2. Pyrexia (fever)
  3. Headache (pain in head)
  4. Somnolence (a state of near-sleep, a strong desire for sleep)
  5. Agitation (state of anxiety or nervous excitement)
  6. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  7. Decreased appetite
  8. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  9. Vomiting
  10. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  1. Back pain
  2. Anaemia (lack of blood)
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  4. Insomnia (sleeplessness)
  5. Fatigue (feeling of tiredness)
  6. Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
  7. Palpitations (feelings or sensations that your heart is pounding or racing)
  8. Pyrexia (fever)
  9. Suicidal ideation
  10. Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
  1. Pyrexia (fever)
  2. Nausea (feeling of having an urge to vomit)
  3. Headache (pain in head)
  4. Back pain
  5. Cellulitis (infection under the skin)
  6. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  7. Pain
  8. Pulmonary embolism (blockage of the main artery of the lung)
  9. Bone disorder
  10. Drug screen positive
  1. Pain
  2. Nausea (feeling of having an urge to vomit)
  3. Pyrexia (fever)
  4. Oedema peripheral (superficial swelling)
  5. Dehydration (dryness resulting from the removal of water)
  6. Arthralgia (joint pain)
  7. Rash
  8. Confusional state
  9. Weight decreased
  10. Asthenia (weakness)
  1. Nausea (feeling of having an urge to vomit)
  2. Fatigue (feeling of tiredness)
  3. Pain
  4. Drug hypersensitivity
  5. Vomiting
  6. Erythema (redness of the skin)
  7. Scar
  8. Hypertension (high blood pressure)
  9. Skin hypertrophy (skin cells enlarges)
  10. Skin induration (an abnormally hard spot or area on the skin)
  1. Pain in extremity
  2. Pneumonia
  3. Osteomyelitis (infection of bone)
  4. Impaired healing
  5. Dysphagia (condition in which swallowing is difficult or painful)
  6. Asthenia (weakness)
  7. Bone disorder
  8. Fatigue (feeling of tiredness)
  9. Spinal osteoarthritis (joint cartilage loss in spine)
  10. Anhedonia (inability to experience pleasure from activities usually found enjoyable)

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study

Do you take Bactrim and Zoloft?

You are not alone:

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Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. (latest outcomes from Bactrim 53,096 users)


Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 112,881 users)

Browse by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Interactions between Bactrim and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Zoloft and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Bactrim and Zoloft
a b c d e f g h i j k l m n o p q r s t u v w x y z

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What would happen?

Predict new side effects and undetected conditions when you take Bactrim and Zoloft (34,068 reports studied)

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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