Bicillin and Ibuprofen drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among people who take Bicillin and Ibuprofen. Common interactions include cellulitis among females and muscle twitching among males.

The phase IV clinical study analyzes what interactions people who take Bicillin and Ibuprofen have. It is created by eHealthMe based on reports of 17 people who take Bicillin and Ibuprofen from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 26, 2022

17 people who take Bicillin and Ibuprofen together, and have interactions are studied.

What is Bicillin?

Bicillin has active ingredients of penicillin g benzathine. eHealthMe is studying from 613 Bicillin users for its effectiveness, alternative drugs and more.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 210,415 Ibuprofen users for its effectiveness, alternative drugs and more.

Number of Bicillin and Ibuprofen reports submitted per year:

Bicillin and Ibuprofen drug interactions.

Common Bicillin and Ibuprofen drug interactions by gender *:


  1. Cellulitis
  2. Anal fistula
  3. Death
  4. Dementia alzheimer's type
  5. Drug hypersensitivity
  6. Rash
  7. Swelling


  1. Muscle twitching
  2. Anhedonia
  3. Injection site pain
  4. Myoclonus
  5. Pallor
  6. Bone density decreased
  7. Tooth loss
  8. Apnoea
  9. Drug administration error
  10. Anal abscess

Common Bicillin and Ibuprofen drug interactions by age *:






  1. Abasia
  2. Arthralgia
  3. Asthenia
  4. Convulsion
  5. Dizziness
  6. Feeling cold
  7. Injection site pain
  8. Muscle twitching
  9. Myoclonus
  10. Pallor


  1. Anhedonia
  2. Anxiety
  3. Emotional distress
  4. Injury
  5. Tooth loss
  6. Bone density decreased


  1. Drug administration error
  2. Anhedonia
  3. Anxiety
  4. Bone density decreased
  5. Bone loss
  6. Emotional distress
  7. Tooth loss
  8. Depression
  9. Panic attack




  1. Anal abscess
  2. Anal fistula
  3. Nausea
  4. Pollakiuria
  5. Thirst
  6. Tremor
  7. Vomiting
  8. Anhedonia
  9. Anxiety
  10. Chronic kidney disease



Common conditions people have *:

  1. Streptococcal Infection: 7 people, 41.18%
  2. Hiv Infection: 6 people, 35.29%
  3. Syphilis - Tertiary (the formation of chronic gummas, which are soft, tumour-like balls of inflammation which may vary considerably in size. they typically affect the skin, bone, and liver, but can occur anywhere): 2 people, 11.76%
  4. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 2 people, 11.76%
  5. Immunodeficiency Disorders: 1 person, 5.88%
  6. Erysipelas (bacterial skin infection): 1 person, 5.88%
  7. Bone Disorder: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Bicillin and Ibuprofen?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Browse all drug interactions of Bicillin and Ibuprofen:

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Common Ibuprofen side effects:

Browse all side effects of Ibuprofen:

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Common Ibuprofen interactions:

Browse all interactions between Ibuprofen and drugs from A to Z:

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How the study uses the data?

The study uses data from the FDA. It is based on penicillin g benzathine and ibuprofen (the active ingredients of Bicillin and Ibuprofen, respectively), and Bicillin and Ibuprofen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Bicillin and Ibuprofen.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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