Clonazepam and Lotrel drug interactions - from FDA reports

Drug interactions are reported among people who take Clonazepam and Lotrel together. This study is created by eHealthMe based on reports of 168 people who take Clonazepam and Lotrel from FDA, and is updated regularly.

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On Feb, 12, 2019

168 people who take Clonazepam, Lotrel are studied.

Number of reports submitted per year:

Clonazepam and Lotrel drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Pain
  2. Weight decreased
  3. Agitation (state of anxiety or nervous excitement)
  4. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  5. Diarrhoea
  6. Drug hypersensitivity
  7. Drug ineffective
  8. Hallucination (an experience involving the perception of something not present)
  9. Hospitalisation
  10. Insomnia (sleeplessness)
1 - 6 months:


6 - 12 months:
  1. Anaphylactic reaction (serious allergic reaction)
  2. Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
  3. Hypersensitivity
  4. Oropharyngeal swelling
  5. Pharyngitis (inflammation of the pharynx, causing a sore throat)
  6. Throat lesion
1 - 2 years:
  1. Arthropathy
  2. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  3. Hyperglycaemia (high blood sugar)
  4. Intervertebral disc protrusion (spinal disc protrusion)
  5. Type 2 diabetes mellitus
2 - 5 years:
  1. Abdominal pain
  2. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  3. Blindness
  4. Breast mass
  5. Cardiac disorder
  6. Chest pain
  7. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  8. Crying
  9. Deafness
  10. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
5 - 10 years:
  1. Hyperkalaemia (damage to or disease of the kidney)
  2. Hypoaesthesia (reduced sense of touch or sensation)
  3. Hypocalcaemia (levels of calcium in blood serum are abnormally low)
  4. Lymphocyte count decreased
  5. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  6. Photopsia (presence of perceived flashes of light)
  7. Platelet count decreased
  8. White blood cell count decreased
  9. Aspartate aminotransferase increased
  10. Blood glucose increased
10+ years:
  1. Blood testosterone decreased
  2. Prostate cancer
  3. Therapeutic response unexpected
  4. Thrombosis (formation of a blood clot inside a blood vessel)
not specified:
  1. Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
  2. Biliary dilatation
  3. Breast cancer
  4. Bronchial secretion retention
  5. Cellulitis (infection under the skin)
  6. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  7. Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
  8. Decreased interest
  9. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  10. Dental caries

Most common drug interactions by gender *:

  1. Cataract (clouding of the lens inside the eye)
  2. Fatigue (feeling of tiredness)
  3. Dehydration (dryness resulting from the removal of water)
  4. Injury
  5. Depression
  6. Renal failure (kidney dysfunction)
  7. Weight increased
  8. Chest pain
  9. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  10. Oedema peripheral (superficial swelling)
  1. Fatigue (feeling of tiredness)
  2. Nausea (feeling of having an urge to vomit)
  3. Gait disturbance
  4. Abdominal pain upper
  5. Alanine aminotransferase increased
  6. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  7. Arthralgia (joint pain)
  8. Asthenia (weakness)
  9. Cataract (clouding of the lens inside the eye)
  10. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

Most common drug interactions by age *:







  1. Weight increased
  2. Complex partial seizures (epileptic seizure)
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  4. Haematochezia (passage of stools containing blood)
  5. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
  6. Hemiparesis (weakness on one side of the body)
  7. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  8. Muscle rigidity (muscle stiffness)
  9. Paraplegia (paralysis of the legs and lower body)
  10. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  1. Death
  2. Depression
  3. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  4. Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
  5. Grand mal convulsion (a type of generalized seizure that affects the entire brain)
  6. Injection site irritation
  7. Injection site pain
  8. Insomnia (sleeplessness)
  9. Malnutrition (condition that results from eating a diet in which certain nutrients are lacking)
  10. Meningitis bacterial (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
  1. Depression
  2. Pain
  3. Palpitations (feelings or sensations that your heart is pounding or racing)
  4. Renal failure (kidney dysfunction)
  5. Asthenia (weakness)
  6. Cataract (clouding of the lens inside the eye)
  7. Chest pain
  8. Diarrhoea
  9. Dyspnoea (difficult or laboured respiration)
  10. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  1. Diarrhoea
  2. Back pain
  3. Injury
  4. Myalgia (muscle pain)
  5. Renal failure (kidney dysfunction)
  6. Acquired immunodeficiency syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv))
  7. Actinomycosis (infection that causes sores, or abscesses)
  8. Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
  9. Biliary dilatation
  10. Breast cancer
  1. Dizziness
  2. Bone pain
  3. Hypotension (abnormally low blood pressure)
  4. Pruritus (severe itching of the skin)
  5. Asthenia (weakness)
  6. Blood creatinine increased
  7. Blood iron decreased
  8. Cardiac failure congestive
  9. Diarrhoea
  10. Injury

* Approximation only. Some reports may have incomplete information.

Do you take Clonazepam and Lotrel?

You are not alone:

Related studies


Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Clonazepam 83,696 users)


Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. (latest outcomes from Lotrel 12,303 users)

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Interactions between Clonazepam and drugs from A to Z
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What would happen?

Predict new side effects and undetected conditions when you take Clonazepam and Lotrel (24,561 reports studied)

FDA reports used in this study

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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