Concerta and Folic acid drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among people who take Concerta and Folic acid. Common interactions include asthenia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people who take Concerta and Folic acid have. It is created by eHealthMe based on reports of 74 people who take Concerta and Folic acid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

74 people who take Concerta and Folic acid together, and have interactions are studied.

What is Concerta?

Concerta has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 21,978 Concerta users for its effectiveness, alternative drugs and more.

What is Folic acid?

Folic acid has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 124,889 Folic acid users for its effectiveness, alternative drugs and more.

Number of Concerta and Folic acid reports submitted per year:

Concerta and Folic acid drug interactions.

Common Concerta and Folic Acid drug interactions by gender *:


  1. Asthenia
  2. Cholecystitis chronic
  3. Cholesterosis
  4. Diarrhoea
  5. Faeces discoloured
  6. Fatigue
  7. Fibromyalgia
  8. Hypokalaemia
  9. Injection site pain
  10. Malaise


  1. Pyrexia
  2. Weight decreased
  3. Osteonecrosis of jaw
  4. Pain
  5. Vision blurred
  6. Constipation
  7. Dizziness
  8. Dry eye
  9. Fall
  10. Hypertension

Common Concerta and Folic Acid drug interactions by age *:




  1. Hypertension
  2. Abdominal distension
  3. Abdominal pain
  4. Abnormal behaviour
  5. Amnesia
  6. Anaemia
  7. Animal bite
  8. Anogenital warts
  9. Arrhythmia
  10. Arteriosclerosis coronary artery


  1. Injection site pain
  2. Abdominal discomfort
  3. Arthritis
  4. Asthma
  5. Calculus ureteric
  6. Calculus urinary
  7. Cerebral venous thrombosis
  8. Cholecystitis chronic
  9. Clostridium difficile colitis
  10. Completed suicide


  1. Abdominal discomfort
  2. Abdominal pain
  3. Abdominal pain upper
  4. Biliary dyskinesia
  5. Cholecystitis chronic
  6. Cholesterosis
  7. Deep vein thrombosis
  8. Diarrhoea
  9. Faeces discoloured
  10. Hypokalaemia


  1. Arthralgia
  2. Blood pressure increased
  3. Dissociation
  4. Fibromyalgia
  5. Hallucination, visual
  6. Malaise
  7. Pruritus
  8. Type 2 diabetes mellitus
  9. Deep vein thrombosis
  10. Pulmonary embolism


  1. Oedema peripheral
  2. Osteitis
  3. Osteoarthritis
  4. Osteonecrosis of jaw
  5. Osteoporosis
  6. Radius fracture
  7. Rib fracture
  8. Skin papilloma
  9. Skin ulcer
  10. Spinal fracture


  1. Atrioventricular block complete
  2. Dyspnoea
  3. Fall
  4. Haemolytic anaemia
  5. Head injury
  6. Memory impairment
  7. Nausea
  8. Nephrolithiasis
  9. Platelet count decreased
  10. Sick sinus syndrome


  1. Asthenia
  2. Cataract
  3. Diverticulum
  4. Ecchymosis
  5. Haematoma
  6. Haemorrhagic anaemia
  7. Headache
  8. Intraocular pressure increased
  9. Muscular weakness
  10. Myasthenia gravis

Common conditions people have *:

  1. Osteoporosis (bones weak and more likely to break): 14 people, 18.92%
  2. Stress And Anxiety: 7 people, 9.46%
  3. Pain: 7 people, 9.46%
  4. Depression: 6 people, 8.11%
  5. Ankylosing Spondylitis (type of arthritis affecting the spine): 6 people, 8.11%
  6. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 6.76%
  7. Inflammation: 5 people, 6.76%
  8. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 5 people, 6.76%
  9. Psoriasis (immune-mediated disease that affects the skin): 4 people, 5.41%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Concerta and Folic acid?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Common Concerta and Folic acid interactions:

Browse all drug interactions of Concerta and Folic acid:

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Common Concerta interactions:

Browse all interactions between Concerta and drugs from A to Z:

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Common Folic acid interactions:

Browse all interactions between Folic acid and drugs from A to Z:

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How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride and folic acid (the active ingredients of Concerta and Folic acid, respectively), and Concerta and Folic acid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Concerta and Folic acid.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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