Coumadin and Chlorothiazide drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among people who take Coumadin and Chlorothiazide. Common interactions include cardiomegaly among females and activities of daily living impaired among males.

The phase IV clinical study analyzes what interactions people who take Coumadin and Chlorothiazide have. It is created by eHealthMe based on reports of 10 people who take Coumadin and Chlorothiazide from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2022

10 people who take Coumadin and Chlorothiazide together, and have interactions are studied.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 131,493 Coumadin users for its effectiveness, alternative drugs and more.

What is Chlorothiazide?

Chlorothiazide has active ingredients of chlorothiazide. eHealthMe is studying from 1,093 Chlorothiazide users for its effectiveness, alternative drugs and more.

Number of Coumadin and Chlorothiazide reports submitted per year:

Coumadin and Chlorothiazide drug interactions.

Common Coumadin and Chlorothiazide drug interactions by gender *:


  1. Cardiomegaly
  2. Cellulitis
  3. Drug administration error
  4. Dysphonia
  5. Dyspnoea
  6. Extremity contracture
  7. Haematuria present
  8. Hepatic congestion
  9. Hepatomegaly
  10. Hypoxia


  1. Activities of daily living impaired
  2. Anaemia
  3. Azotaemia
  4. Benign prostatic hyperplasia
  5. Blood creatinine increased
  6. Blood glucose increased
  7. Blood pressure decreased
  8. Blood pressure increased
  9. Blood urea increased
  10. Bradycardia

Common Coumadin and Chlorothiazide drug interactions by age *:


  1. International normalised ratio increased


  1. Abdominal distension
  2. Anaemia
  3. Cardiomegaly
  4. Cellulitis
  5. Fluid retention
  6. Hepatic congestion
  7. Hepatomegaly
  8. Hypoxia
  9. Postoperative wound infection
  10. Pulmonary hypertension




  1. Asthma
  2. Dyspnoea
  3. Fluid retention
  4. Pulmonary arterial hypertension
  5. Respiratory disorder
  6. Right ventricular failure
  7. Upper respiratory tract infection






  1. Calcification of muscle
  2. Dysphonia
  3. Extremity contracture
  4. Impaired self-care
  5. Joint contracture
  6. Joint range of motion decreased
  7. Joint stiffness
  8. Mobility decreased
  9. Muscle fibrosis
  10. Musculoskeletal stiffness


  1. Cervical vertebral fracture
  2. Fatigue
  3. Haematemesis
  4. Haematuria present
  5. Loin pain
  6. Nausea
  7. Vomiting

Common conditions people have *:

  1. Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 1 person, 10.00%
  2. Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 10.00%
  3. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 10.00%
  4. Ocular Rosacea (redness, irritation or burning of the eyes): 1 person, 10.00%
  5. Nuclear Magnetic Resonance Imaging Abdominal: 1 person, 10.00%
  6. High Blood Pressure: 1 person, 10.00%
  7. High Blood Cholesterol: 1 person, 10.00%
  8. Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 10.00%
  9. Computerised Tomogram Abdomen: 1 person, 10.00%
  10. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Coumadin and Chlorothiazide?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Browse all drug interactions of Coumadin and Chlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Coumadin interactions:

Browse all interactions between Coumadin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Chlorothiazide interactions:

Browse all interactions between Chlorothiazide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on warfarin sodium and chlorothiazide (the active ingredients of Coumadin and Chlorothiazide, respectively), and Coumadin and Chlorothiazide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Coumadin and Chlorothiazide.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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