Cozaar and Metformin drug interactions - from FDA reports

Summary

Drug interactions are reported among people who take Cozaar and Metformin together. This study is created by eHealthMe based on reports of 2,580 people who take Cozaar and Metformin from FDA, and is updated regularly.



What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on losartan potassium and metformin hydrochloride (the active ingredients of Cozaar and Metformin, respectively), and Cozaar and Metformin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Cozaar?

Cozaar has active ingredients of losartan potassium. It is often used in high blood pressure. (latest outcomes from Cozaar 37,171 users)

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 259,096 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.


On Mar, 13, 2019

2,580 people who take Cozaar, Metformin are studied.


Number of reports submitted per year:

Cozaar and Metformin drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  2. Cough
  3. Constipation
  4. Neuropathy peripheral (surface nerve damage)
  5. Cerebral haemorrhage (bleeding within the brain)
  6. Neutropenia (an abnormally low number of neutrophils)
  7. Pruritus (severe itching of the skin)
  8. Visual impairment
  9. Alopecia (absence of hair from areas of the body)
  10. Arthralgia (joint pain)
1 - 6 months:
  1. Hepatitis acute
  2. Neutropenia (an abnormally low number of neutrophils)
  3. Anomaly of external ear congenital
  4. Polydactyly (more than five fingers or toes on a hand or foot)
  5. Oedema peripheral (superficial swelling)
  6. Diarrhoea
  7. Drug ineffective
  8. Drug intolerance (drug sensitivity)
  9. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
  10. Loss of consciousness
6 - 12 months:
  1. Abdominal pain
  2. Angioedema (rapid swelling of the dermis)
  3. Dyspnoea (difficult or laboured respiration)
  4. Weight decreased
  5. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
  6. Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
  7. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  8. Asthenia (weakness)
  9. Blood bicarbonate decreased
  10. Blood calcium decreased
1 - 2 years:
  1. Neutropenia (an abnormally low number of neutrophils)
  2. Hepatitis acute
  3. Anxiety
  4. Haemoglobin decreased
  5. Overdose
  6. Rash morbilliform (a rash that looks like measles)
  7. Rectal haemorrhage (bleeding from anus)
  8. Renal failure (kidney dysfunction)
  9. Adverse drug reaction
  10. Adverse event
2 - 5 years:
  1. Abdominal pain
  2. Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
  3. Deafness
  4. Diarrhoea
  5. Hyperthermia (body temperature greatly above normal)
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
  8. Anaemia (lack of blood)
  9. Arteriosclerosis (thickening and hardening of arteries)
  10. Cardiac failure congestive
5 - 10 years:
  1. Hypotension (abnormally low blood pressure)
  2. Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
  3. Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
  4. Sinus bradycardia (an unusually slow heartbeat due to heart disease)
  5. Bradycardia (abnormally slow heart action)
  6. Non-cardiac chest pain
  7. Chronic kidney disease
  8. Angina pectoris (chest pain due to ischemia of the heart muscle)
  9. Cardiovascular disorder (heart diseases)
  10. Cholestatic liver injury (due to injury bile cannot floe from liver)
10+ years:
  1. Cough
  2. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  3. Lip dry
  4. Lip exfoliation
  5. Lip swelling
  6. Meningioma (a diverse set of tumours arising from the meninges)
  7. Muscle spasms (muscle contraction)
  8. Nephrolithiasis (calculi in the kidneys)
  9. Neuropathy peripheral (surface nerve damage)
  10. Night sweats (sweating in night)
not specified:
  1. Nausea (feeling of having an urge to vomit)
  2. Blood glucose increased
  3. Diarrhoea
  4. Dyspnoea (difficult or laboured respiration)
  5. Fatigue (feeling of tiredness)
  6. Weight decreased
  7. Asthenia (weakness)
  8. Dizziness
  9. Vomiting
  10. Pain

Most common drug interactions by gender *:

female:
  1. Drug ineffective
  2. Pain
  3. Headache (pain in head)
  4. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  5. Arthralgia (joint pain)
  6. Fall
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Oedema peripheral (superficial swelling)
  9. Pain in extremity
  10. Cardiac failure congestive
male:
  1. Blood glucose increased
  2. Fatigue (feeling of tiredness)
  3. Cardiac failure congestive
  4. Headache (pain in head)
  5. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  6. Insomnia (sleeplessness)
  7. Drug ineffective
  8. Depression
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

Most common drug interactions by age *:

0-1:
  1. Anomaly of external ear congenital
  2. Polydactyly (more than five fingers or toes on a hand or foot)
  3. Premature baby
2-9:

n/a

10-19:
  1. Abdominal pain upper
  2. Diarrhoea
  3. Nausea (feeling of having an urge to vomit)
  4. Pancreatitis acute (sudden inflammation of pancreas)
  5. Vomiting
  6. Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
  7. Drug ineffective
  8. Encephalitis herpes (inflammation of the brain due to herpes infection)
  9. Memory impairment
  10. Mucous membrane disorder (disease of mucous membrane)
20-29:
  1. Erythema multiforme (a type of hypersensitivity reaction)
30-39:
  1. Nausea (feeling of having an urge to vomit)
  2. Diarrhoea
  3. Vomiting
  4. Fatigue (feeling of tiredness)
  5. Hyperglycaemia (high blood sugar)
  6. Asthenia (weakness)
  7. Depression
  8. Dizziness
  9. Urinary tract infection
  10. Abdominal discomfort
40-49:
  1. Nausea (feeling of having an urge to vomit)
  2. Weight decreased
  3. Blood glucose increased
  4. Cardiac failure congestive
  5. Vomiting
  6. Back pain
  7. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  8. Abdominal pain upper
  9. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  10. Chest pain
50-59:
  1. Hypotension (abnormally low blood pressure)
  2. Dizziness
  3. Fatigue (feeling of tiredness)
  4. Arthralgia (joint pain)
  5. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  6. Anxiety
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Pain
  9. Pain in extremity
  10. Abdominal pain
60+:
  1. Nausea (feeling of having an urge to vomit)
  2. Dyspnoea (difficult or laboured respiration)
  3. Cardiac failure congestive
  4. Headache (pain in head)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Vomiting
  7. Drug ineffective
  8. Pain in extremity
  9. Oedema peripheral (superficial swelling)
  10. Arthralgia (joint pain)

* Approximation only. Some reports may have incomplete information.


Do you take Cozaar and Metformin?

You are not alone:




Related publications that referenced our studies


Results from eHealthMe (non-FDA) reports of taking Cozaar and Metformin together

Drug effectiveness (drug is found to be effective) over time *:
Cozaar:
  • < 1 month: 50% (1 of 2 people)
  • 1 - 6 months: 66% (2 of 3 people)
  • 6 - 12 months: 0.0% (0 of 1 people)
  • 1 - 2 years: 50% (4 of 8 people)
  • 2 - 5 years: 53% (7 of 13 people)
  • 5 - 10 years: 38% (5 of 13 people)
  • 10+ years: 83% (5 of 6 people)
  • not specified: 100% (2 of 2 people)
Metformin:
  • < 1 month: 0.0% (0 of 1 people)
  • 1 - 6 months: 25% (1 of 4 people)
  • 6 - 12 months: 0.0% (0 of 0 people)
  • 1 - 2 years: 57% (4 of 7 people)
  • 2 - 5 years: 61% (8 of 13 people)
  • 5 - 10 years: 62% (10 of 16 people)
  • 10+ years: 16% (1 of 6 people)
  • not specified: 0.0% (0 of 0 people)
Drug effectiveness (drug is found to be effective) by gender *:
Cozaar:
  • female: 44% (11 of 25 people)
  • male: 65% (15 of 23 people)
Metformin:
  • female: 60% (15 of 25 people)
  • male: 40% (9 of 22 people)
Drug effectiveness (drug is found to be effective) by age *:
Cozaar:
  • 0-1: 0.0% (0 of 0 people)
  • 2-9: 0.0% (0 of 0 people)
  • 10-19: 0.0% (0 of 0 people)
  • 20-29: 0.0% (0 of 0 people)
  • 30-39: 0.0% (0 of 2 people)
  • 40-49: 50.0% (1 of 2 people)
  • 50-59: 68.0% (11 of 16 people)
  • 60+: 50.0% (14 of 28 people)
Metformin:
  • 0-1: 0.0% (0 of 0 people)
  • 2-9: 0.0% (0 of 0 people)
  • 10-19: 0.0% (0 of 0 people)
  • 20-29: 0.0% (0 of 0 people)
  • 30-39: 100.0% (2 of 2 people)
  • 40-49: 0.0% (0 of 2 people)
  • 50-59: 46.0% (7 of 15 people)
  • 60+: 53.0% (15 of 28 people)
Race of the people *:
  • African American, Non-Hispanic: 2.03 %
  • American Indian/Alaska Native: 0.0 %
  • Asian: 1.52 %
  • Hispanic: 5.08 %
  • Native Hawaiians/Pacific Islanders: 0.0 %
  • Two or more races: 3.05 %
  • White, Non-Hispanic: 88.32 %

* Approximation only.


Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Cozaar and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Metformin and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Cozaar and Metformin
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Cozaar and Metformin



FDA reports used in this study


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