Diovan and Metformin drug interactions - from FDA reports

Summary

Drug interactions are reported among people who take Diovan and Metformin together. This study is created by eHealthMe based on reports of 4,690 people who take Diovan and Metformin from FDA, and is updated regularly.



What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on valsartan and metformin hydrochloride (the active ingredients of Diovan and Metformin, respectively), and Diovan and Metformin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Diovan?

Diovan has active ingredients of valsartan. It is often used in high blood pressure. (latest outcomes from Diovan 72,779 users)

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 259,096 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.


On Mar, 07, 2019

4,690 people who take Diovan, Metformin are studied.


Number of reports submitted per year:

Diovan and Metformin drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Renal impairment (severely reduced kidney function)
  2. Diarrhoea
  3. Blood creatinine increased
  4. Blood glucose increased
  5. Pneumonia
  6. Diabetes mellitus inadequate control
  7. Drug ineffective
  8. Fatigue (feeling of tiredness)
  9. Hypotension (abnormally low blood pressure)
  10. Pyrexia (fever)
1 - 6 months:
  1. Blood glucose increased
  2. Glucose urine present
  3. Cardiac failure congestive
  4. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  5. Blood triglycerides increased
  6. Carotid artery stenosis (narrowing of carotid artery)
  7. Hyperkalaemia (damage to or disease of the kidney)
  8. Hypoglycaemia (deficiency of glucose in the bloodstream)
  9. Toxic skin eruption (skin breakdown due to toxic substance)
  10. Angina pectoris (chest pain due to ischemia of the heart muscle)
6 - 12 months:
  1. Blood glucose increased
  2. Abdominal pain
  3. Abortion (termination of pregnancy)
  4. Acute myocardial infarction (acute heart attack)
  5. Drug exposure during pregnancy
  6. Hypoglycaemia (deficiency of glucose in the bloodstream)
  7. Idiopathic thrombocytopenic purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting)
  8. Platelet count decreased
  9. Anaemia (lack of blood)
  10. Back pain
1 - 2 years:
  1. Dyspnoea (difficult or laboured respiration)
  2. Hypertensive crisis
  3. C-reactive protein increased
  4. Electrocardiogram qrs complex prolonged
  5. Impaired work ability
  6. Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
  7. Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
  8. Refractory anaemia (an anaemia which does not respond to treatment)
  9. Angina pectoris (chest pain due to ischemia of the heart muscle)
  10. Blood pressure diastolic decreased
2 - 5 years:
  1. Abdominal pain upper
  2. Renal failure (kidney dysfunction)
  3. Nausea (feeling of having an urge to vomit)
  4. Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
  5. Cholecystitis chronic (long lasting infection of gallbladder)
  6. Dyspnoea (difficult or laboured respiration)
  7. Anxiety
  8. Nephrolithiasis (calculi in the kidneys)
  9. Thrombocytopenia (decrease of platelets in blood)
  10. Chronic kidney disease
5 - 10 years:
  1. Fall
  2. Hair colour changes
  3. Hair disorder
  4. Intervertebral disc protrusion (spinal disc protrusion)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Pyrexia (fever)
  7. Angina pectoris (chest pain due to ischemia of the heart muscle)
  8. Arrhythmia (irregular heartbeat)
  9. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  10. Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
10+ years:
  1. Renal impairment (severely reduced kidney function)
  2. Anaemia (lack of blood)
  3. Abdominal pain upper
  4. Cataract (clouding of the lens inside the eye)
  5. Cerebral infarction (less blood supply to brain resulting tissue damage)
  6. Hypoglycaemia (deficiency of glucose in the bloodstream)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Nephrolithiasis (calculi in the kidneys)
  9. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  10. Pulmonary embolism (blockage of the main artery of the lung)
not specified:
  1. Blood glucose increased
  2. Nausea (feeling of having an urge to vomit)
  3. Dyspnoea (difficult or laboured respiration)
  4. Pain
  5. Fatigue (feeling of tiredness)
  6. Dizziness
  7. Diarrhoea
  8. Weight decreased
  9. Headache (pain in head)
  10. Drug ineffective

Most common drug interactions by gender *:

female:
  1. Diarrhoea
  2. Fall
  3. Fatigue (feeling of tiredness)
  4. Dizziness
  5. Drug ineffective
  6. Arthralgia (joint pain)
  7. Anxiety
  8. Pain in extremity
  9. Oedema peripheral (superficial swelling)
  10. Vomiting
male:
  1. Dyspnoea (difficult or laboured respiration)
  2. Blood glucose increased
  3. Cardiac failure congestive
  4. Headache (pain in head)
  5. Weight increased
  6. Vomiting
  7. Asthenia (weakness)
  8. Hypotension (abnormally low blood pressure)
  9. Anaemia (lack of blood)
  10. Pneumonia

Most common drug interactions by age *:

0-1:
  1. Chest pain
  2. Hypersensitivity
  3. Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
  4. Nausea (feeling of having an urge to vomit)
  5. Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
  6. Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
  7. Cardiomyopathy (weakening of the heart muscle)
  8. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  9. Femur fracture
  10. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
2-9:

n/a

10-19:
  1. Abdominal pain
  2. Anxiety
  3. Cholecystitis chronic (long lasting infection of gallbladder)
  4. Gallbladder disorder
  5. Injury
  6. Insomnia (sleeplessness)
  7. Pain
20-29:
  1. Blood glucose increased
  2. Gouty arthritis (joint inflammation with crystal formation)
  3. Localised infection (infection at the single location)
  4. Oedema peripheral (superficial swelling)
  5. Staphylococcus test positive
  6. Nausea (feeling of having an urge to vomit)
  7. Pain
  8. Abdominal pain upper
  9. Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
  10. Cholecystitis chronic (long lasting infection of gallbladder)
30-39:
  1. Abdominal pain
  2. Arthralgia (joint pain)
  3. Headache (pain in head)
  4. Constipation
  5. Gastroenteritis (inflammation of stomach and intestine)
  6. Angina pectoris (chest pain due to ischemia of the heart muscle)
  7. Abortion (termination of pregnancy)
  8. Back pain
  9. Drug exposure during pregnancy
  10. Diarrhoea
40-49:
  1. Nausea (feeling of having an urge to vomit)
  2. Pain
  3. Cardiac failure congestive
  4. Pain in extremity
  5. Arthralgia (joint pain)
  6. Dyspnoea (difficult or laboured respiration)
  7. Diarrhoea
  8. Vomiting
  9. Hyperlipidaemia (presence of excess lipids in the blood)
  10. Weight increased
50-59:
  1. Dyspnoea (difficult or laboured respiration)
  2. Weight decreased
  3. Anaemia (lack of blood)
  4. Anxiety
  5. Asthenia (weakness)
  6. Chest pain
  7. Depression
  8. Drug ineffective
  9. Pneumonia
  10. Vomiting
60+:
  1. Dyspnoea (difficult or laboured respiration)
  2. Blood glucose increased
  3. Vomiting
  4. Asthenia (weakness)
  5. Fall
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Arthralgia (joint pain)
  8. Decreased appetite
  9. Pain in extremity
  10. Anaemia (lack of blood)

* Approximation only. Some reports may have incomplete information.

Do you take Diovan and Metformin?


You are not alone:




Related publications that referenced our studies

Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Diovan and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Metformin and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Diovan and Metformin
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Diovan and Metformin (59,999 reports studied)



FDA reports used in this study


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