Diphen and Misoprostol drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Diphen and Misoprostol. Common interactions include gait disturbance among females and pain among males.
The phase IV clinical study analyzes what interactions people who take Diphen and Misoprostol have. It is created by eHealthMe based on reports of 67 people who take Diphen and Misoprostol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
67 people who take Diphen and Misoprostol together, and have interactions are studied.
What is Diphen?
Diphen has active ingredients of diphenhydramine hydrochloride. eHealthMe is studying from 87,645 Diphen users for its effectiveness, alternative drugs and more.
What is Misoprostol?
Misoprostol has active ingredients of misoprostol. It is often used in abortion. eHealthMe is studying from 7,628 Misoprostol users for its effectiveness, alternative drugs and more.
Number of Diphen and Misoprostol reports submitted per year:

Common Diphen and Misoprostol drug interactions by gender *:
female:
- Gait disturbance
- Haematoma
- Hypoaesthesia
- Neuralgia
- Oedema peripheral
- Peripheral swelling
- Confusional state
- Lung infiltration
- Urinary tract infection
- Blood pressure increased
male:
- Pain
- Pneumonia
- Cardiac failure congestive
- Heart rate decreased
- Renal disorder
- Rheumatoid arthritis
- Urinary tract infection
- Wound infection
- Anaemia
- Granulocytopenia
Common Diphen and Misoprostol drug interactions by age *:
0-1:
n/a
2-9:
n/a
10-19:
- Aggression
- Amniotic cavity infection
- Anaphylactic reaction
- Anaphylactoid syndrome of pregnancy
- Anxiety
- Aphasia
- Beta haemolytic streptococcal infection
- Blood alkaline phosphatase increased
- Blood bicarbonate decreased
- Blood creatinine decreased
20-29:
n/a
30-39:
- Anaemia
- Aphasia
- Cerebrovascular accident
- Dizziness
- Dyspnoea
- Fatigue
- Gastric ulcer
- Infusion related reaction
- Insomnia
- Muscle spasms
40-49:
n/a
50-59:
- Blood pressure systolic decreased
- Colitis ulcerative
- Cystitis
- Drug hypersensitivity
- Drug ineffective
- Headache
- Hypoxia
- Infusion related reaction
- Infusion site pain
- Mental impairment
60+:
- Dyspnoea
- Rheumatoid arthritis
- Tendon rupture
- Thrombosis
- Weight increased
- Pain
- Blood potassium increased
- Fatigue
- Aortic aneurysm
- Blood glucose increased
Common conditions people have *:
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 18 people, 26.87%
- Immunodeficiency Common Variable: 18 people, 26.87%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 11.94%
- Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 7 people, 10.45%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 8.96%
- Combined Immunodeficiency: 5 people, 7.46%
* Approximation only. Some reports may have incomplete information.
Do you take Diphen and Misoprostol?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
- Diphen (87,645 reports)
- Misoprostol (7,628 reports)
Browse all drug interactions of Diphen and Misoprostol:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Diphen side effects:
- Fatigue (feeling of tiredness): 8,422 reports
- High blood pressure: 7,919 reports
- Headache (pain in head): 7,440 reports
- Pain: 6,769 reports
- Joint pain: 6,496 reports
- Drug ineffective: 6,251 reports
- Sinusitis (inflammation of sinus): 5,702 reports
Browse all side effects of Diphen:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Misoprostol side effects:
- Pain: 553 reports
- Birth control: 503 reports
- Fever: 401 reports
- Dizziness: 360 reports
- Drug ineffective: 358 reports
Browse all side effects of Misoprostol:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Diphen interactions:
- Diphen and Prednisone: 17,795 reports
- Diphen and Acetaminophen: 10,345 reports
- Diphen and Vitamin d: 9,154 reports
- Diphen and Aspirin: 8,681 reports
- Diphen and Methotrexate: 8,666 reports
- Diphen and Gabapentin: 7,900 reports
- Diphen and Pantoprazole: 7,812 reports
- Diphen and Tylenol: 7,215 reports
- Diphen and Vitamin d3: 6,985 reports
- Diphen and Omeprazole: 6,952 reports
Browse all interactions between Diphen and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Misoprostol interactions:
- Misoprostol and Mifepristone: 1,573 reports
- Misoprostol and Doxycycline: 1,369 reports
- Misoprostol and Methotrexate: 768 reports
- Misoprostol and Prednisone: 660 reports
- Misoprostol and Enbrel: 518 reports
- Misoprostol and Diclofenac sodium: 387 reports
- Misoprostol and Humira: 355 reports
- Misoprostol and Omeprazole: 308 reports
- Misoprostol and Tramadol: 301 reports
- Misoprostol and Folic acid: 291 reports
Browse all interactions between Misoprostol and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on diphenhydramine hydrochloride and misoprostol (the active ingredients of Diphen and Misoprostol, respectively), and Diphen and Misoprostol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Diphen and Misoprostol.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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