Doxepin hydrochloride and Spironolactone drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Doxepin hydrochloride and Spironolactone. Common interactions include anaemia among females and anaemia among males.
The phase IV clinical study analyzes what interactions people who take Doxepin hydrochloride and Spironolactone have. It is created by eHealthMe based on reports of 13 people who take Doxepin hydrochloride and Spironolactone from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
13 people who take Doxepin hydrochloride and Spironolactone together, and have interactions are studied.
What is Doxepin hydrochloride?
Doxepin hydrochloride has active ingredients of doxepin hydrochloride. It is often used in insomnia. eHealthMe is studying from 1,931 Doxepin hydrochloride users for its effectiveness, alternative drugs and more.
What is Spironolactone?
Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 101,998 Spironolactone users for its effectiveness, alternative drugs and more.
Number of Doxepin hydrochloride and Spironolactone reports submitted per year:

Common Doxepin Hydrochloride and Spironolactone drug interactions by gender *:
female:
- Anaemia
- Bundle branch block left
- Cardiac failure
- Cardiac failure congestive
- Cardiomegaly
- Central nervous system lesion
- Cerebrovascular accident
- Diarrhoea
- Gastric disorder
- Gastrointestinal disorder
male:
- Anaemia
- Anxiety
- Diarrhoea
- Productive cough
- Weight decreased
- White blood cell count decreased
Common Doxepin Hydrochloride and Spironolactone drug interactions by age *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Headache
40-49:
n/a
50-59:
- Chronic kidney disease
- Constipation
- Hypertensive heart disease
- Large intestinal ulcer
- Productive cough
- Pyrexia
- Renal failure
- Respiratory failure
- Vomiting
- Weight decreased
60+:
- Anaemia
- Constipation
- Diarrhoea
- White blood cell count decreased
Common conditions people have *:
- Hypokalemia (low potassium): 3 people, 23.08%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 15.38%
- Depression: 2 people, 15.38%
- Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch): 2 people, 15.38%
- Infection: 2 people, 15.38%
- Constipation: 2 people, 15.38%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 15.38%
- Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 15.38%
- Feeling Hot: 2 people, 15.38%
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 15.38%
* Approximation only. Some reports may have incomplete information.
Do you take Doxepin hydrochloride and Spironolactone?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
- Doxepin hydrochloride (1,931 reports)
- Spironolactone (101,998 reports)
Browse all drug interactions of Doxepin hydrochloride and Spironolactone:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Doxepin hydrochloride side effects:
- Dizziness: 151 reports
- Stress and anxiety: 145 reports
- Insomnia (sleeplessness): 141 reports
- Fatigue (feeling of tiredness): 117 reports
- Drug ineffective: 104 reports
Browse all side effects of Doxepin hydrochloride:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Spironolactone side effects:
- Breathing difficulty: 8,125 reports
- Fatigue (feeling of tiredness): 6,809 reports
- Hypotension (abnormally low blood pressure): 5,698 reports
- Diarrhea: 5,440 reports
- Dizziness: 5,097 reports
Browse all side effects of Spironolactone:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Doxepin hydrochloride interactions:
- Doxepin hydrochloride and Gabapentin: 218 reports
- Doxepin hydrochloride and Aspirin: 170 reports
- Doxepin hydrochloride and Lorazepam: 140 reports
- Doxepin hydrochloride and Lopurin: 119 reports
- Doxepin hydrochloride and Vitamin d: 118 reports
- Doxepin hydrochloride and Baclofen: 112 reports
- Doxepin hydrochloride and Prednisone: 106 reports
- Doxepin hydrochloride and Vitamin d3: 103 reports
- Doxepin hydrochloride and Ativan: 102 reports
Browse all interactions between Doxepin hydrochloride and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Spironolactone interactions:
- Spironolactone and Furosemide: 34,324 reports
- Spironolactone and Aspirin: 15,329 reports
- Spironolactone and Omeprazole: 11,226 reports
- Spironolactone and Lasix: 10,837 reports
- Spironolactone and Metformin: 10,504 reports
- Spironolactone and Carvedilol: 10,246 reports
- Spironolactone and Lisinopril: 9,050 reports
- Spironolactone and Pantoprazole: 8,681 reports
- Spironolactone and Digoxin: 8,612 reports
- Spironolactone and Amlodipine: 7,729 reports
Browse all interactions between Spironolactone and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on doxepin hydrochloride and spironolactone (the active ingredients of Doxepin hydrochloride and Spironolactone, respectively), and Doxepin hydrochloride and Spironolactone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Doxepin hydrochloride and Spironolactone.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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