Doxepin hydrochloride and Tramadol drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Doxepin hydrochloride and Tramadol. Common interactions include nasal discomfort among females and cholecystitis infective among males.
The phase IV clinical study analyzes what interactions people who take Doxepin hydrochloride and Tramadol have. It is created by eHealthMe based on reports of 60 people who take Doxepin hydrochloride and Tramadol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
60 people who take Doxepin hydrochloride and Tramadol together, and have interactions are studied.
What is Doxepin hydrochloride?
Doxepin hydrochloride has active ingredients of doxepin hydrochloride. It is often used in insomnia. eHealthMe is studying from 1,963 Doxepin hydrochloride users for its effectiveness, alternative drugs and more.
What is Tramadol?
Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 200,135 Tramadol users for its effectiveness, alternative drugs and more.
Number of Doxepin hydrochloride and Tramadol reports submitted per year:

Common Doxepin Hydrochloride and Tramadol drug interactions by gender *:
female:
- Nasal discomfort
- Neck pain
- Nephrolithiasis
- Nervousness
- Neuropathy peripheral
- Overdose
- Pneumonia
- Radial nerve palsy
- Rib fracture
- Sepsis
male:
- Cholecystitis infective
- Cholelithiasis
- Decreased immune responsiveness
- Drug ineffective
- Erythema of eyelid
- Eye infection
- Eye pain
- Eye pruritus
- Impaired driving ability
- Ocular hyperaemia
Common Doxepin Hydrochloride and Tramadol drug interactions by age *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Drug toxicity
- Cardio-respiratory arrest
- Completed suicide
- Drug abuse
40-49:
- Eye swelling
- Conjunctivitis
- Decreased immune responsiveness
- Erythema of eyelid
- Eye infection
- Eye pain
- Eye pruritus
- Impaired driving ability
- Ocular hyperaemia
- Pneumonia
50-59:
- Sepsis
- Suicide attempt
- Urinary tract infection
- Bundle branch block left
- Cardiac failure
- Cardiac failure congestive
- Cardiomegaly
- Completed suicide
- Dysarthria
- Hypertensive heart disease
60+:
- Cholecystitis infective
- Cholelithiasis
- Weight decreased
- Drug hypersensitivity
- Aggression
- Diarrhoea
- Hypoacusis
- Pain in extremity
- Pulmonary oedema
- Staphylococcal infection
Common conditions people have *:
- Diabetes: 9 people, 15.00%
- Essential Hypertension (primary hypertension): 7 people, 11.67%
- Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 6 people, 10.00%
- Depression: 6 people, 10.00%
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 6 people, 10.00%
- Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 10.00%
- Hypoaesthesia (reduced sense of touch or sensation): 6 people, 10.00%
- Gout (uric acid crystals building up in the body): 6 people, 10.00%
- Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 6 people, 10.00%
- Prostatomegaly (enlargement of the prostate): 6 people, 10.00%
* Approximation only. Some reports may have incomplete information.
Do you take Doxepin hydrochloride and Tramadol?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
- Doxepin hydrochloride (1,963 reports)
- Tramadol (200,135 reports)
Browse all drug interactions of Doxepin hydrochloride and Tramadol:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Doxepin hydrochloride side effects:
- Dizziness: 151 reports
- Stress and anxiety: 145 reports
- Insomnia (sleeplessness): 141 reports
- Fatigue (feeling of tiredness): 117 reports
- Drug ineffective: 104 reports
Browse all side effects of Doxepin hydrochloride:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Tramadol side effects:
- Pain: 14,785 reports
- Fatigue (feeling of tiredness): 12,058 reports
- Drug ineffective: 10,171 reports
- Headache (pain in head): 9,302 reports
- Diarrhea: 9,053 reports
- Nausea and vomiting: 8,804 reports
- Dizziness: 8,432 reports
Browse all side effects of Tramadol:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Doxepin hydrochloride interactions:
- Doxepin hydrochloride and Gabapentin: 218 reports
- Doxepin hydrochloride and Aspirin: 170 reports
- Doxepin hydrochloride and Lorazepam: 140 reports
- Doxepin hydrochloride and Lopurin: 119 reports
- Doxepin hydrochloride and Vitamin d: 118 reports
- Doxepin hydrochloride and Baclofen: 112 reports
- Doxepin hydrochloride and Prednisone: 106 reports
- Doxepin hydrochloride and Vitamin d3: 103 reports
- Doxepin hydrochloride and Amlodipine: 102 reports
Browse all interactions between Doxepin hydrochloride and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Tramadol interactions:
- Tramadol and Gabapentin: 23,835 reports
- Tramadol and Omeprazole: 22,862 reports
- Tramadol and Aspirin: 21,558 reports
- Tramadol and Prednisone: 17,905 reports
- Tramadol and Lisinopril: 16,314 reports
- Tramadol and Furosemide: 15,345 reports
- Tramadol and Oxycontin: 14,187 reports
- Tramadol and Hydrocodone bitartrate and acetaminophen: 14,161 reports
- Tramadol and Amlodipine: 13,348 reports
- Tramadol and Metformin: 13,342 reports
Browse all interactions between Tramadol and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on doxepin hydrochloride and tramadol hydrochloride (the active ingredients of Doxepin hydrochloride and Tramadol, respectively), and Doxepin hydrochloride and Tramadol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Doxepin hydrochloride and Tramadol.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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