Estazolam and Zopiclone drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among 52 people who take Estazolam and Zopiclone. Common interactions include osteoarthritis among females, and cardiac failure among males.

The phase IV clinical study analyzes what interactions people who take Estazolam and Zopiclone have. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 28, 2023

52 people who take Estazolam and Zopiclone together, and have interactions are studied.

What is Estazolam?

Estazolam has active ingredients of estazolam. It is used in insomnia. Currently, eHealthMe is studying from 2,601 Estazolam users.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is used in insomnia. Currently, eHealthMe is studying from 49,229 Zopiclone users.

Number of Estazolam and Zopiclone reports submitted per year:

Estazolam and Zopiclone drug interactions.

Common Estazolam and Zopiclone drug interactions by gender *:


  1. Osteoarthritis
  2. Pancytopenia
  3. Drug toxicity
  4. Abdominal pain
  5. Anaemia
  6. Cardiac arrest
  7. Chills
  8. Colitis
  9. Electrocardiogram t wave amplitude decreased
  10. Febrile neutropenia


  1. Cardiac failure
  2. Liver injury
  3. Depressed mood
  4. Depression
  5. Fatigue
  6. Myelodysplastic syndrome
  7. Paraesthesia
  8. Schizophrenia
  9. Septic shock
  10. Acute myeloid leukaemia

Common Estazolam and Zopiclone drug interactions by age *:








  1. Depressed mood
  2. Drug ineffective
  3. Fatigue
  4. Paraesthesia
  5. Hospitalisation
  6. Hypersomnia
  7. Sedation
  8. Suicide attempt
  9. Affective disorder
  10. Anhedonia


  1. Abdominal pain
  2. Chills
  3. Colitis
  4. Peritonitis
  5. Pyrexia
  6. Retroperitoneal abscess
  7. Blood alkaline phosphatase increased
  8. Blood cholinesterase increased
  9. Constipation
  10. Depression


  1. Dehydration
  2. Hypophagia
  3. Nausea
  4. Pulmonary hypertension
  5. Renal failure acute
  6. Rhabdomyolysis
  7. Schizophrenia


  1. Liver injury
  2. Febrile neutropenia
  3. Herpes zoster
  4. Infection
  5. Nausea
  6. Shoulder operation
  7. Acute graft versus host disease in intestine
  8. Depression
  9. Graft versus host disease
  10. Myelodysplastic syndrome


  1. Cardiac failure
  2. Drug toxicity
  3. Aphagia
  4. Arteriosclerosis coronary artery
  5. Asphyxia
  6. Cardio-respiratory arrest
  7. Chloasma
  8. Chronic kidney disease
  9. Dermatitis exfoliative
  10. Disseminated intravascular coagulation

Common conditions people have *:

  1. Constipation: 15 people, 28.85%
  2. Nausea (feeling of having an urge to vomit): 10 people, 19.23%
  3. Diabetes: 9 people, 17.31%
  4. Pain: 9 people, 17.31%
  5. Lung Cancer - Non-Small Cell (lung cancer): 7 people, 13.46%
  6. Nausea And Vomiting: 7 people, 13.46%
  7. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 11.54%
  8. Diarrhea: 6 people, 11.54%
  9. Cough: 5 people, 9.62%
  10. Fever: 5 people, 9.62%

* Approximation only. Some reports may have incomplete information.

Do you take Estazolam and Zopiclone?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Drug side effects by duration, gender and age:

Common Estazolam drug interactions:

Browse interactions between Estazolam and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Zopiclone drug interactions:

Browse interactions between Zopiclone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on estazolam and eszopiclone (the active ingredients of Estazolam and Zopiclone, respectively), and Estazolam and Zopiclone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Estazolam and Zopiclone.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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