Felodipine and Metformin drug interactions - from FDA reports
Drug interactions are reported among people who take Felodipine and Metformin together. This study is created by eHealthMe based on reports of 1,066 people who take Felodipine and Metformin from FDA, and is updated regularly.
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1,066 people who take Felodipine, Metformin are studied.
Number of reports submitted per year:

Most common drug interactions over time *:
< 1 month:
- Renal failure acute (rapid kidney dysfunction)
- Hyperkalaemia (damage to or disease of the kidney)
- Coma (state of unconsciousness lasting more than six hours)
- Diarrhoea
- Fatigue (feeling of tiredness)
- Hypoglycaemia (deficiency of glucose in the bloodstream)
- Muscular weakness (muscle weakness)
- Nausea (feeling of having an urge to vomit)
- Vomiting
- Acute respiratory failure
1 - 6 months:
- Cough
- Nausea (feeling of having an urge to vomit)
- Pyrexia (fever)
- Rash erythematous (redness of the skin)
- Vomiting
- Bradycardia (abnormally slow heart action)
- Chills (felling of cold)
- Decreased appetite
- Dizziness
- Haematocrit decreased
6 - 12 months:
- Subdural haematoma (blood collects between the skull and the surface of the brain)
- Blood glucose increased
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Hypoglycaemia (deficiency of glucose in the bloodstream)
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
1 - 2 years:
- Death
- Cardiac arrest
- Cardiac failure congestive
- Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
- Chronic kidney disease
- Diarrhoea
- Lactic acidosis (low ph in body tissues)
- Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
- Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
- Sepsis (a severe blood infection that can lead to organ failure and death)
2 - 5 years:
- Bradycardia (abnormally slow heart action)
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Hypoaesthesia (reduced sense of touch or sensation)
- Renal impairment (severely reduced kidney function)
- Cough
- Haematocrit decreased
- Haematocrit increased
- Haemoglobin decreased
- Lymphocyte count decreased
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
5 - 10 years:
- Chills (felling of cold)
- Death
- Decreased appetite
- Dizziness
- Incontinence (lack of moderation or self-control)
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Pyrexia (fever)
- Cardiac failure congestive
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Heart rate increased
10+ years:
- Ovarian cancer (cancer of ovary)
- Cardiac arrest
- Device dislocation
- Diarrhoea
- Drug intolerance (drug sensitivity)
- Gastritis (inflammation of stomach)
- Haemorrhoids (a swollen vein or group of veins in the region of the anus)
- Hypercholesterolaemia (high levels of cholesterol in the blood)
- Hypertriglyceridaemia (excess of triglycerides in the blood)
- Ileus (a painful obstruction of the ileum or other part of the intestine)
not specified:
- Renal failure acute (rapid kidney dysfunction)
- Dyspnoea (difficult or laboured respiration)
- Dizziness
- Syncope (loss of consciousness with an inability to maintain postural tone)
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Bradycardia (abnormally slow heart action)
- Vomiting
- Pain
- Diarrhoea
- Confusional state
Most common drug interactions by gender *:
female:
- Pain
- Renal failure acute (rapid kidney dysfunction)
- Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
- Malaise (a feeling of general discomfort or uneasiness)
- Fall
- Nausea (feeling of having an urge to vomit)
- Drug ineffective
- Weight decreased
- Anaemia (lack of blood)
- Blood glucose increased
male:
- Renal failure acute (rapid kidney dysfunction)
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Blood creatinine increased
- Cough
- Diarrhoea
- Haemorrhage (bleeding)
- Hypoglycaemia (deficiency of glucose in the bloodstream)
- Pain in extremity
- Pneumonia
- Haemoglobin decreased
Most common drug interactions by age *:
0-1:
- Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
- Prostate cancer
2-9:
- Chest pain
- Haemoglobin decreased
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
- Vomiting
- Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
- Alanine aminotransferase increased
- Aspartate aminotransferase increased
- Bacterial infection
- Blood amylase increased
10-19:
n/a
20-29:
n/a
30-39:
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
- Hypoglycaemia (deficiency of glucose in the bloodstream)
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Anaphylactic reaction (serious allergic reaction)
- Angioedema (rapid swelling of the dermis)
- Blood glucose increased
- Cardiac failure congestive
- Condition
- Confusional state
40-49:
- Bradycardia (abnormally slow heart action)
- Intentional overdose
- Blood creatinine increased
- Diarrhoea
- Malaise (a feeling of general discomfort or uneasiness)
- Chronic kidney disease
- Hyperlipidaemia (presence of excess lipids in the blood)
- Cough
- Pyrexia (fever)
- Abdominal distension
50-59:
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
- Atrioventricular block complete (heart block complete)
- Bradycardia (abnormally slow heart action)
- Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
- Syncope (loss of consciousness with an inability to maintain postural tone)
- Multiple injuries
- Therapeutic agent toxicity (poisoning by ability to cure substance)
- Asthenia (weakness)
- Chest pain
60+:
- Renal failure acute (rapid kidney dysfunction)
- Dizziness
- Bradycardia (abnormally slow heart action)
- Diarrhoea
- Fatigue (feeling of tiredness)
- Lactic acidosis (low ph in body tissues)
- Nausea (feeling of having an urge to vomit)
- Drug ineffective
- Hyperkalaemia (damage to or disease of the kidney)
- Pain in extremity
* Approximation only. Some reports may have incomplete information.
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Related studies
Felodipine
Felodipine has active ingredients of felodipine. It is often used in high blood pressure. (latest outcomes from Felodipine 10,517 users)
Metformin
Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 259,096 users)
Browse by gender and age
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Interactions between Felodipine and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y zInteractions between Metformin and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all drug interactions of Felodipine and Metformin
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- ŽUPANIĆ KRMEK DU, BRAJKOVIĆ I, BEKIĆ D, KRNIĆ A, JURKOVIĆ P, PAVLOVIĆ T, "CALCIFIED DEEP VEIN THROMBOSIS IN A PATIENT WITH RECURRENT DEEP VEIN THROMBOSIS AND SARCOIDOSIS", Acta Medica Croatica, 2014 Mar .
- Lee IS, Kim KS, Kim KH, Park J, Jeong HS, Kim Y, Na YC, Chung WS, Ahn KS, Lee SG, Um JY, "Antihyperglycemic and Antiobesity Effects of JAL2 on db/db Mice", Evidence-Based Complementary and Alternative Medicine, 2016 Mar .
What would happen?
Predict new side effects and undetected conditions when you take Felodipine and Metformin (49,916 reports studied)
FDA reports used in this study
- Want to find out more about the FDA reports used in the study? You can request them from FDA.
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