Glipizide and Metformin drug interactions - from FDA reports

Summary

Drug interactions are reported among people who take Glipizide and Metformin together. This study is created by eHealthMe based on reports of 17,661 people who take Glipizide and Metformin from FDA, and is updated regularly.



What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on glipizide and metformin hydrochloride (the active ingredients of Glipizide and Metformin, respectively), and Glipizide and Metformin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Glipizide?

Glipizide has active ingredients of glipizide. It is often used in diabetes. (latest outcomes from Glipizide 44,241 users)

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 259,096 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.


On Feb, 23, 2019

17,661 people who take Glipizide, Metformin are studied.


Number of reports submitted per year:

Glipizide and Metformin drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Back pain
  2. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  3. Blood glucose increased
  4. Renal impairment (severely reduced kidney function)
  5. Diarrhoea
  6. Renal failure acute (rapid kidney dysfunction)
  7. Confusional state
  8. Hypoglycaemia (deficiency of glucose in the bloodstream)
  9. Dizziness
  10. Nausea (feeling of having an urge to vomit)
1 - 6 months:
  1. Back pain
  2. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  3. Renal impairment (severely reduced kidney function)
  4. Blood glucose increased
  5. Hypoglycaemia (deficiency of glucose in the bloodstream)
  6. Nausea (feeling of having an urge to vomit)
  7. Cough
  8. Vision blurred
  9. Drug intolerance (drug sensitivity)
  10. Abortion (termination of pregnancy)
6 - 12 months:
  1. Nausea (feeling of having an urge to vomit)
  2. Pruritus (severe itching of the skin)
  3. Back pain
  4. Constipation
  5. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  6. Fatigue (feeling of tiredness)
  7. Hepatic enzyme increased
  8. Stress
  9. Tinnitus (a ringing in the ears)
  10. Burning sensation
1 - 2 years:
  1. Respiratory failure (inadequate gas exchange by the respiratory system)
  2. Renal failure acute (rapid kidney dysfunction)
  3. Abdominal pain
  4. Blood glucose increased
  5. Diarrhoea
  6. Nausea (feeling of having an urge to vomit)
  7. Sepsis (a severe blood infection that can lead to organ failure and death)
  8. Hypoglycaemia (deficiency of glucose in the bloodstream)
  9. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  10. Vomiting
2 - 5 years:
  1. Diarrhoea
  2. Nausea (feeling of having an urge to vomit)
  3. Hypoglycaemia (deficiency of glucose in the bloodstream)
  4. Chronic kidney disease
  5. Dehydration (dryness resulting from the removal of water)
  6. Vomiting
  7. Abdominal distension
  8. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  9. Headache (pain in head)
  10. Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
5 - 10 years:
  1. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  2. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  3. Dehydration (dryness resulting from the removal of water)
  4. Chronic kidney disease
  5. Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
  6. Anaemia (lack of blood)
  7. Diarrhoea
  8. Hypoglycaemia (deficiency of glucose in the bloodstream)
  9. Cardiac failure congestive
  10. Fall
10+ years:
  1. Chronic kidney disease
  2. Constipation
  3. Urinary tract infection
  4. Fatigue (feeling of tiredness)
  5. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  6. Pancreatic carcinoma (pancreatic cancer)
  7. Abdominal pain
  8. Alopecia (absence of hair from areas of the body)
  9. Asthma
  10. Bladder cancer
not specified:
  1. Blood glucose increased
  2. Nausea (feeling of having an urge to vomit)
  3. Weight decreased
  4. Diarrhoea
  5. Drug ineffective
  6. Fatigue (feeling of tiredness)
  7. Dyspnoea (difficult or laboured respiration)
  8. Dizziness
  9. Vomiting
  10. Pain

Most common drug interactions by gender *:

female:
  1. Headache (pain in head)
  2. Dyspnoea (difficult or laboured respiration)
  3. Asthenia (weakness)
  4. Decreased appetite
  5. Pain in extremity
  6. Fall
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Arthralgia (joint pain)
  9. Injection site pain
  10. Weight increased
male:
  1. Blood glucose increased
  2. Drug ineffective
  3. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  4. Vomiting
  5. Decreased appetite
  6. Headache (pain in head)
  7. Blood glucose decreased
  8. Cardiac failure congestive
  9. Hypertension (high blood pressure)
  10. Fall

Most common drug interactions by age *:

0-1:
  1. Flushing (the warm, red condition of human skin)
  2. Nausea (feeling of having an urge to vomit)
  3. Psoriasis (immune-mediated disease that affects the skin)
  4. Weight decreased
  5. Abdominal pain
  6. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
  7. Arteriosclerosis (thickening and hardening of arteries)
  8. Ascites (accumulation of fluid in the abdominal cavity)
  9. Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
  10. Blood creatinine increased
2-9:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Abdominal pain
  3. Abdominal rigidity
  4. Abdominal tenderness
  5. Acidosis (build-up of carbon dioxide in the blood)
  6. Blood creatinine increased
  7. Blood glucose increased
  8. Blood urea increased
  9. Drug level above therapeutic
  10. Faecaloma (hard mass of fecal matter)
10-19:
  1. Vomiting
  2. Hypoglycaemia (deficiency of glucose in the bloodstream)
  3. Anxiety
  4. Intentional overdose
  5. Abdominal pain
  6. Abdominal pain upper
  7. Adnexa uteri pain
  8. Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
  9. Arthralgia (joint pain)
  10. Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
20-29:
  1. Completed suicide (act of taking one's own life)
  2. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  3. Vision blurred
  4. Abdominal pain
  5. Hyperglycaemia (high blood sugar)
  6. Hyperlipidaemia (presence of excess lipids in the blood)
  7. Bradycardia (abnormally slow heart action)
  8. Cerebral infarction (less blood supply to brain resulting tissue damage)
  9. Dyspepsia (indigestion)
  10. Encephalopathy (functioning of the brain is affected by some agent or condition)
30-39:
  1. Nausea (feeling of having an urge to vomit)
  2. Completed suicide (act of taking one's own life)
  3. Vomiting
  4. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  5. Pain
  6. Blood glucose increased
  7. Dizziness
  8. Fatigue (feeling of tiredness)
  9. Abdominal pain
  10. Pulmonary embolism (blockage of the main artery of the lung)
40-49:
  1. Blood glucose increased
  2. Nausea (feeling of having an urge to vomit)
  3. Pain
  4. Weight decreased
  5. Diarrhoea
  6. Drug ineffective
  7. Headache (pain in head)
  8. Vomiting
  9. Dyspnoea (difficult or laboured respiration)
  10. Fatigue (feeling of tiredness)
50-59:
  1. Dyspnoea (difficult or laboured respiration)
  2. Blood glucose decreased
  3. Injection site pain
  4. Anxiety
  5. Pain in extremity
  6. Arthralgia (joint pain)
  7. Depression
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  10. Asthenia (weakness)
60+:
  1. Blood glucose increased
  2. Nausea (feeling of having an urge to vomit)
  3. Blood glucose decreased
  4. Decreased appetite
  5. Pain
  6. Fall
  7. Headache (pain in head)
  8. Cardiac failure congestive
  9. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  10. Pain in extremity

* Approximation only. Some reports may have incomplete information.

Do you take Glipizide and Metformin?


You are not alone:




Related publications that referenced our studies

Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Glipizide and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Metformin and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Glipizide and Metformin
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Glipizide and Metformin (57,431 reports studied)



FDA reports used in this study


Recent updates

Recent general studies
Recent personal studies


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Submit your testimonial

  • Please fill in your Testimonial.
  • Please enter a minimum of 10 characters for your Testimonial.
  • Please fill in your Name.

Please wait...

{progressItem}

Thank you!