Hydroxyurea and Clozapine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyurea and Clozapine. Common interactions include ascites among females and neutropenia among males.

The phase IV clinical study analyzes what interactions people who take Hydroxyurea and Clozapine have. It is created by eHealthMe based on reports of 18 people who take Hydroxyurea and Clozapine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 18, 2023

18 people who take Hydroxyurea and Clozapine together, and have interactions are studied.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 13,918 Hydroxyurea users for its effectiveness, alternative drugs and more.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 66,418 Clozapine users for its effectiveness, alternative drugs and more.

Number of Hydroxyurea and Clozapine reports submitted per year:

Common Hydroxyurea and Clozapine drug interactions by gender *:

female:

Ascites
Cell marker increased
Duodenal ulcer
Fibrosis
Gastric ulcer perforation
Gastritis
Gastrointestinal haemorrhage
Gastrointestinal inflammation
Helicobacter gastritis
Lymphocytic infiltration

male:

Neutropenia
Mean cell volume increased
Polycythaemia
Red blood cell count decreased

Common Hydroxyurea and Clozapine drug interactions by age *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Mean cell volume increased
Polycythaemia
Red blood cell count decreased

30-39:

n/a

40-49:

n/a

50-59:

Neutropenia

60+:

Haematocrit increased
Haemoglobin increased
Gastric ulcer perforation
Gastritis
Gastrointestinal haemorrhage
Gastrointestinal inflammation
Helicobacter gastritis
Lymphocytic infiltration
Metaplasia
Nausea

Common conditions people have *:

Polycythaemia (proportion of blood volume that is occupied by red blood cells increases): 11 people, 61.11%
Constipation: 10 people, 55.56%
High Blood Cholesterol: 8 people, 44.44%
Bipolar Disorder (mood disorder): 4 people, 22.22%
Mania (a state of abnormally elevated or irritable mood): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyurea and Clozapine?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .