Isordil and Wellbutrin drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among 20 people who take Isordil and Wellbutrin. Common interactions include formication among females, and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people who take Isordil and Wellbutrin have. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 24, 2023

20 people who take Isordil and Wellbutrin together, and have interactions are studied.

What is Isordil?

Isordil has active ingredients of isosorbide dinitrate. Currently, eHealthMe is studying from 2,994 Isordil users.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is used in depression. Currently, eHealthMe is studying from 113,156 Wellbutrin users.

Number of Isordil and Wellbutrin reports submitted per year:

Isordil and Wellbutrin drug interactions.

Common Isordil and Wellbutrin drug interactions by gender *:


  1. Formication
  2. Frustration
  3. Gastric mucosal hypertrophy
  4. Gastritis erosive
  5. Gastroenteritis
  6. Gastrointestinal pain
  7. Gastrooesophageal reflux disease
  8. Gingival pain
  9. Haematemesis
  10. Haematuria


  1. Cardiac failure congestive
  2. Constipation
  3. Micturition disorder
  4. Musculoskeletal chest pain
  5. Myocardial infarction
  6. Nephrogenic anaemia
  7. Renal injury
  8. Small intestinal obstruction
  9. Abdominal pain upper
  10. Arthralgia

Common Isordil and Wellbutrin drug interactions by age *:










  1. Acute coronary syndrome
  2. Cardiac disorder
  3. Chest pain
  4. Diabetes mellitus inadequate control
  5. Diabetes mellitus
  6. Diabetic retinopathy
  7. Cataract
  8. Type 2 diabetes mellitus


  1. Erythema
  2. Eustachian tube dysfunction
  3. Extrapyramidal disorder
  4. Eyelid ptosis
  5. Fatigue
  6. Fibromyalgia
  7. Flank pain
  8. Fluid retention
  9. Formication
  10. Frustration


  1. Cardiovascular disorder
  2. Death
  3. Gastrointestinal haemorrhage
  4. Hepatic enzyme increased
  5. Stent placement


  1. Chronic kidney disease
  2. Death
  3. Blindness
  4. Cardiac failure
  5. Cardiac failure congestive
  6. Colitis ischaemic
  7. Constipation
  8. Depressed level of consciousness
  9. Erythema
  10. Fall

Common conditions people have *:

  1. Chest Pain: 5 people, 25.00%
  2. Diabetes: 4 people, 20.00%
  3. Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 4 people, 20.00%
  4. Pain: 2 people, 10.00%
  5. Joint Pain: 2 people, 10.00%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.00%
  7. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.00%
  8. High Blood Pressure: 1 person, 5.00%
  9. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.00%
  10. Cough: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Isordil and Wellbutrin?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drug side effects by duration, gender and age:

Common Isordil drug interactions:

Browse interactions between Isordil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Wellbutrin drug interactions:

Browse interactions between Wellbutrin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on isosorbide dinitrate and bupropion hydrochloride (the active ingredients of Isordil and Wellbutrin, respectively), and Isordil and Wellbutrin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Isordil and Wellbutrin.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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