Klonopin and Metolazone drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Klonopin and Metolazone. Common interactions include fatigue among females and asthenia among males.
The phase IV clinical study analyzes what interactions people who take Klonopin and Metolazone have. It is created by eHealthMe based on reports of 105 people who take Klonopin and Metolazone from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
105 people who take Klonopin and Metolazone together, and have interactions are studied.
What is Klonopin?
Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 62,428 Klonopin users for its effectiveness, alternative drugs and more.
What is Metolazone?
Metolazone has active ingredients of metolazone. It is often used in swelling. eHealthMe is studying from 12,267 Metolazone users for its effectiveness, alternative drugs and more.
Number of Klonopin and Metolazone reports submitted per year:

Klonopin and Metolazone drug interactions by gender *:
Klonopin and Metolazone drug interactions by age *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Klonopin and Metolazone?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
- Klonopin (62,428 reports)
- Metolazone (12,267 reports)
Browse all drug interactions of Klonopin and Metolazone:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Klonopin side effects:
- Stress and anxiety: 5,458 reports
- Fatigue (feeling of tiredness): 4,937 reports
- Drug ineffective: 4,898 reports
- Depression: 4,404 reports
- Headache (pain in head): 4,220 reports
- Pain: 4,144 reports
- Insomnia (sleeplessness): 3,957 reports
Browse all side effects of Klonopin:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Metolazone side effects:
- Breathing difficulty: 1,469 reports
- Acute kidney failure: 981 reports
- Hypotension (abnormally low blood pressure): 876 reports
- Fatigue (feeling of tiredness): 875 reports
- Weakness: 866 reports
Browse all side effects of Metolazone:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Klonopin interactions:
- Klonopin and Seroquel: 5,867 reports
- Klonopin and Neurontin: 4,829 reports
- Klonopin and Wellbutrin: 4,788 reports
- Klonopin and Cymbalta: 4,736 reports
- Klonopin and Zoloft: 4,700 reports
- Klonopin and Synthroid: 4,476 reports
- Klonopin and Aspirin: 4,295 reports
- Klonopin and Ambien: 4,100 reports
- Klonopin and Effexor: 4,029 reports
- Klonopin and Lamictal: 3,923 reports
Browse all interactions between Klonopin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Metolazone interactions:
- Metolazone and Furosemide: 5,105 reports
- Metolazone and Aspirin: 3,027 reports
- Metolazone and Lasix: 2,818 reports
- Metolazone and Spironolactone: 2,546 reports
- Metolazone and Allopurinol: 2,084 reports
- Metolazone and Omeprazole: 1,814 reports
- Metolazone and Digoxin: 1,730 reports
- Metolazone and Gabapentin: 1,728 reports
- Metolazone and Carvedilol: 1,696 reports
- Metolazone and Prednisone: 1,629 reports
Browse all interactions between Metolazone and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on clonazepam and metolazone (the active ingredients of Klonopin and Metolazone, respectively), and Klonopin and Metolazone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Klonopin and Metolazone.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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