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Leucovorin calcium and Metformin hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among 82 people who take Leucovorin calcium and Metformin hydrochloride. Common interactions include osteoporosis among females, and diarrhoea among males.

The phase IV clinical study analyzes what interactions people who take Leucovorin calcium and Metformin hydrochloride have. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2023

82 people who take Leucovorin calcium and Metformin hydrochloride together, and have interactions are studied.

What is Leucovorin calcium?

Leucovorin calcium has active ingredients of leucovorin calcium. It is used in rheumatoid arthritis. Currently, eHealthMe is studying from 22,779 Leucovorin calcium users.

What is Metformin hydrochloride?

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is used in diabetes. Currently, eHealthMe is studying from 51,892 Metformin hydrochloride users.

Number of Leucovorin calcium and Metformin hydrochloride reports submitted per year:

Leucovorin calcium and Metformin hydrochloride drug interactions.

Common Leucovorin Calcium and Metformin Hydrochloride drug interactions by gender *:

female:

  1. Osteoporosis
  2. Pain
  3. Rotator cuff syndrome
  4. Scoliosis
  5. Tendonitis
  6. Musculoskeletal pain
  7. Respiratory failure
  8. Ascites
  9. Diarrhoea
  10. Fatigue

male:

  1. Diarrhoea
  2. Pain
  3. Bone erosion
  4. C-reactive protein increased
  5. Cholestasis
  6. Drug ineffective
  7. Drug intolerance
  8. Drug-induced liver injury
  9. Dyspepsia
  10. Gastrointestinal infection

Common Leucovorin Calcium and Metformin Hydrochloride drug interactions by age *:

0-1:

  1. Foetal disorder
  2. Foetal exposure during pregnancy
  3. Low birth weight baby
  4. Neutropenia neonatal
  5. Premature baby

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Oropharyngeal pain
  2. Urinary tract infection
  3. Mixed liver injury

50-59:

  1. Haemoglobin increased
  2. Hepatic cirrhosis
  3. Hepatic fibrosis
  4. Hepatic steatosis
  5. Hypertension
  6. Hypokinesia
  7. Infection
  8. Joint ankylosis
  9. Liver disorder
  10. Localised infection

60+:

  1. Tumour lysis syndrome
  2. Cholestasis
  3. Perineal infection
  4. Pulmonary embolism
  5. Anaemia
  6. Arthralgia
  7. Asthenia
  8. Dyspnoea
  9. Headache
  10. Ascites

Common conditions people have *:

  1. High Blood Pressure: 15 people, 18.29%
  2. Type 2 Diabetes: 8 people, 9.76%
  3. Multiple Myeloma (cancer of the plasma cells): 8 people, 9.76%
  4. Dyslipidaemia (abnormal amount of lipids): 8 people, 9.76%
  5. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 8.54%
  6. Psoriasis (immune-mediated disease that affects the skin): 7 people, 8.54%
  7. Hypokalemia (low potassium): 7 people, 8.54%
  8. Colorectal Cancer Stage Iv (cancer of colon and rectal spreads to liver or lung): 6 people, 7.32%
  9. Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 6 people, 7.32%
  10. K-Ras Gene Mutation: 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

Do you take Leucovorin calcium and Metformin hydrochloride?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Drug side effects by duration, gender and age:

Common Leucovorin calcium drug interactions:

Browse interactions between Leucovorin calcium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Metformin hydrochloride drug interactions:

Browse interactions between Metformin hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on leucovorin calcium and metformin hydrochloride (the active ingredients of Leucovorin calcium and Metformin hydrochloride, respectively), and Leucovorin calcium and Metformin hydrochloride (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Leucovorin calcium and Metformin hydrochloride.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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