Linzess and Trental drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported only by a few people who take Linzess and Trental together.
The phase IV clinical study analyzes what interactions people who take Linzess and Trental have. It is created by eHealthMe based on reports of 4 people who take the same drugs from the FDA, and is updated regularly.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
4 people who take Linzess and Trental together, and have interactions are studied.
What is Linzess?
Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 19,590 Linzess users for its effectiveness, alternative drugs and more.
What is Trental?
Trental has active ingredients of pentoxifylline. eHealthMe is studying from 3,427 Trental users for its effectiveness, alternative drugs and more.
Number of Linzess and Trental reports submitted per year:

Common Linzess and Trental drug interactions by gender *:
female:
- Asthenia
- Somnolence
- Abdominal distension
- Acute coronary syndrome
- Acute left ventricular failure
- Acute respiratory failure
- Chronic kidney disease
- Drug ineffective
male:
n/a
Common Linzess and Trental drug interactions by age *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
n/a
60+:
- Asthenia
- Somnolence
- Abdominal distension
- Drug ineffective
* Approximation only. Some reports may have incomplete information.
Do you take Linzess and Trental?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
Browse all drug interactions of Linzess and Trental:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Linzess side effects:
- Diarrhea: 4,125 reports
- Drug ineffective: 3,698 reports
- Constipation: 1,267 reports
- Abdominal pain: 881 reports
- Fatigue (feeling of tiredness): 878 reports
- Headache (pain in head): 779 reports
Browse all side effects of Linzess:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Trental side effects:
- Weakness: 353 reports
- Breathing difficulty: 304 reports
- Pain: 242 reports
- Fatigue (feeling of tiredness): 199 reports
- Headache (pain in head): 186 reports
- Stress and anxiety: 184 reports
Browse all side effects of Trental:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Linzess interactions:
- Linzess and Gabapentin: 1,921 reports
- Linzess and Vitamin d: 1,736 reports
- Linzess and Aspirin: 1,659 reports
- Linzess and Omeprazole: 1,653 reports
- Linzess and Miralax: 1,301 reports
- Linzess and Pantoprazole: 1,048 reports
- Linzess and Lisinopril: 1,035 reports
- Linzess and Xyrem: 1,029 reports
- Linzess and Lyrica: 1,011 reports
- Linzess and Tramadol: 1,000 reports
Browse all interactions between Linzess and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Trental interactions:
- Trental and Lasix: 541 reports
- Trental and Aspirin: 443 reports
- Trental and Lipitor: 353 reports
- Trental and Coumadin: 306 reports
- Trental and Zocor: 264 reports
- Trental and Plavix: 258 reports
- Trental and Norvasc: 257 reports
- Trental and Prednisone: 255 reports
- Trental and Synthroid: 247 reports
- Trental and Prilosec: 238 reports
Browse all interactions between Trental and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on linaclotide and pentoxifylline (the active ingredients of Linzess and Trental, respectively), and Linzess and Trental (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Linzess and Trental.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Vesicare and Genitourinary Tract Infection - 8 seconds ago
- Metoclopramide and Autonomic Nervous System Imbalance - 8 seconds ago
- Mucinex D and Bradycardia - 10 seconds ago
- Psyllium and Atelectasis - 11 seconds ago
- Cefdinir and Cialis drug interaction - 13 seconds ago
- Neoral and Gastrointestinal Candidiasis - 19 seconds ago
- Flexeril and Obsessive-Compulsive Disorder - 20 seconds ago
- Subutex and Soma drug interaction - 21 seconds ago
- Clopra and Novolog drug interaction - 24 seconds ago
- Xolair and Infertility - 26 seconds ago