Lisinopril and Spironolactone drug interactions - from FDA reports

Summary

Drug interactions are reported among people who take Lisinopril and Spironolactone together. This study is created by eHealthMe based on reports of 5,810 people who take Lisinopril and Spironolactone from FDA, and is updated regularly.



What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on lisinopril and spironolactone (the active ingredients of Lisinopril and Spironolactone, respectively), and Lisinopril and Spironolactone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Lisinopril?

Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. (latest outcomes from Lisinopril 228,281 users)

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. (latest outcomes from Spironolactone 61,531 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.


On Feb, 10, 2019

5,810 people who take Lisinopril, Spironolactone are studied.


Number of reports submitted per year:

Lisinopril and Spironolactone drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Hyperkalaemia (damage to or disease of the kidney)
  2. Back pain
  3. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  4. Renal impairment (severely reduced kidney function)
  5. Dizziness
  6. Dehydration (dryness resulting from the removal of water)
  7. Cardiac failure
  8. Condition
  9. Oedema peripheral (superficial swelling)
  10. Dyspnoea (difficult or laboured respiration)
1 - 6 months:
  1. Hyperkalaemia (damage to or disease of the kidney)
  2. Proteinuria (presence of protein in the urine)
  3. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
  4. Cardiac failure
  5. Back pain
  6. Calciphylaxis (is a syndrome with vascular calcium accumulation)
  7. Renal failure acute (rapid kidney dysfunction)
  8. Dehydration (dryness resulting from the removal of water)
  9. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  10. Chronic kidney disease
6 - 12 months:
  1. Hyperkalaemia (damage to or disease of the kidney)
  2. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  3. Joint swelling
  4. Swelling
  5. Diarrhoea
  6. Fall
  7. Fatigue (feeling of tiredness)
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Alopecia (absence of hair from areas of the body)
  10. Cartilage injury
1 - 2 years:
  1. Hyperkalaemia (damage to or disease of the kidney)
  2. Chronic kidney disease
  3. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  4. Renal failure acute (rapid kidney dysfunction)
  5. Rectal haemorrhage (bleeding from anus)
  6. Bradycardia (abnormally slow heart action)
  7. Nausea (feeling of having an urge to vomit)
  8. Renal failure (kidney dysfunction)
  9. Blood creatinine increased
  10. Cardiac failure congestive
2 - 5 years:
  1. Chronic kidney disease
  2. Hyperkalaemia (damage to or disease of the kidney)
  3. Renal failure (kidney dysfunction)
  4. Diarrhoea
  5. Iron deficiency anaemia
  6. Renal failure acute (rapid kidney dysfunction)
  7. Dyspnoea (difficult or laboured respiration)
  8. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  9. Hypotension (abnormally low blood pressure)
  10. Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
5 - 10 years:
  1. Angina pectoris (chest pain due to ischemia of the heart muscle)
  2. Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
  3. Depression
  4. Drug ineffective
  5. Gastric ulcer (stomach ulcer)
  6. Hypotension (abnormally low blood pressure)
  7. Pain
  8. Renal injury (kidney injury)
  9. Suicidal ideation
  10. Blood glucose increased
10+ years:
  1. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  2. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  3. Cholecystitis acute (rapid infection of gallbladder)
  4. Drug ineffective
  5. Dyspnoea (difficult or laboured respiration)
  6. Electrolyte imbalance
  7. Gallbladder disorder
  8. Hypotension (abnormally low blood pressure)
  9. Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
  10. Abdominal pain
not specified:
  1. Dyspnoea (difficult or laboured respiration)
  2. Cardiac failure congestive
  3. Nausea (feeling of having an urge to vomit)
  4. Fatigue (feeling of tiredness)
  5. Pain
  6. Asthenia (weakness)
  7. Dizziness
  8. Hypotension (abnormally low blood pressure)
  9. Diarrhoea
  10. Renal failure acute (rapid kidney dysfunction)

Most common drug interactions by gender *:

female:
  1. Pain
  2. Asthenia (weakness)
  3. Anxiety
  4. Fall
  5. Diarrhoea
  6. Vomiting
  7. Dizziness
  8. Chest pain
  9. Renal failure acute (rapid kidney dysfunction)
  10. Dehydration (dryness resulting from the removal of water)
male:
  1. Dyspnoea (difficult or laboured respiration)
  2. Cardiac failure congestive
  3. Fall
  4. Pain
  5. Anaemia (lack of blood)
  6. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  7. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  8. Back pain
  9. Pneumonia
  10. Weight decreased

Most common drug interactions by age *:

0-1:
  1. Apnoea (suspension of external breathing)
  2. Cardiac arrest
  3. Crying
  4. Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
  5. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
  6. Hypotonia (low muscle tone)
  7. Premature baby
  8. Renal failure (kidney dysfunction)
2-9:
  1. Ascites (accumulation of fluid in the abdominal cavity)
  2. Asthenia (weakness)
  3. Cardiac failure
  4. Dyspnoea (difficult or laboured respiration)
  5. Fluid overload (too much fluid in the blood)
  6. Hypotension (abnormally low blood pressure)
  7. Hypoxia (low oxygen in tissues)
  8. Oedema (fluid collection in tissue)
  9. Oedema peripheral (superficial swelling)
  10. Pleural effusion (water on the lungs)
10-19:
  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Cardiac failure congestive
  3. Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
  4. Nausea (feeling of having an urge to vomit)
  5. Pericardial effusion (fluid around the heart)
  6. Vomiting
  7. Aortic valve incompetence
  8. Blood pressure decreased
  9. Cardiac failure
  10. Cardiomegaly (increased size of heart than normal)
20-29:
  1. Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
  2. Cardiac failure congestive
  3. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  4. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  5. Chest discomfort
  6. Dyspnoea (difficult or laboured respiration)
  7. Influenza like illness
  8. Urinary tract infection
  9. Ventricular fibrillation (abnormally irregular heart rhythm)
  10. Presyncope
30-39:
  1. Nausea (feeling of having an urge to vomit)
  2. Vomiting
  3. Anxiety
  4. Dyspnoea (difficult or laboured respiration)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Pulmonary oedema (fluid accumulation in the lungs)
  7. Dizziness
  8. Fall
  9. Pneumonia
  10. Depression
40-49:
  1. Nausea (feeling of having an urge to vomit)
  2. Weight increased
  3. Fatigue (feeling of tiredness)
  4. Vomiting
  5. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  6. Hypotension (abnormally low blood pressure)
  7. Dehydration (dryness resulting from the removal of water)
  8. Renal failure acute (rapid kidney dysfunction)
  9. Pyrexia (fever)
  10. Dizziness
50-59:
  1. Chest pain
  2. Hyperkalaemia (damage to or disease of the kidney)
  3. Asthenia (weakness)
  4. Anxiety
  5. Vomiting
  6. Diarrhoea
  7. Fall
  8. Dizziness
  9. Hypotension (abnormally low blood pressure)
  10. Dehydration (dryness resulting from the removal of water)
60+:
  1. Dyspnoea (difficult or laboured respiration)
  2. Hyperkalaemia (damage to or disease of the kidney)
  3. Nausea (feeling of having an urge to vomit)
  4. Dizziness
  5. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  6. Anaemia (lack of blood)
  7. Pneumonia
  8. Anxiety
  9. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  10. Dehydration (dryness resulting from the removal of water)

* Approximation only. Some reports may have incomplete information.

Do you take Lisinopril and Spironolactone?


You are not alone:




Related publications that referenced our studies

Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Lisinopril and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Spironolactone and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Lisinopril and Spironolactone
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Lisinopril and Spironolactone (52,418 reports studied)



FDA reports used in this study


Recent updates

Recent general studies
Recent personal studies


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Submit your testimonial

  • Please fill in your Testimonial.
  • Please enter a minimum of 10 characters for your Testimonial.
  • Please fill in your Name.

Please wait...

{progressItem}

Thank you!