Lodine xl and Tylenol drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among people who take Lodine xl and Tylenol. Common interactions include burning sensation among females and pruritus among males.

The phase IV clinical study analyzes what interactions people who take Lodine xl and Tylenol have. It is created by eHealthMe based on reports of 11 people who take Lodine xl and Tylenol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 30, 2022

11 people who take Lodine xl and Tylenol together, and have interactions are studied.

What is Lodine xl?

Lodine xl has active ingredients of etodolac. eHealthMe is studying from 418 Lodine xl users for its effectiveness, alternative drugs and more.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 189,508 Tylenol users for its effectiveness, alternative drugs and more.

Number of Lodine xl and Tylenol reports submitted per year:

Lodine xl and Tylenol drug interactions.

Common Lodine Xl and Tylenol drug interactions by gender *:


  1. Burning sensation
  2. Cholelithiasis
  3. Cholesterosis
  4. Confusion
  5. Constipation
  6. Deep vein thrombosis
  7. Diarrhoea
  8. Drug ineffective
  9. Drug maladministration
  10. Dyspepsia


  1. Pruritus
  2. Adverse event
  3. Benign neoplasm
  4. Benign prostatic hyperplasia
  5. Bile duct stone
  6. Borderline glaucoma
  7. Breast cyst
  8. Bronchial disorder
  9. Carotid bruit
  10. Cataract

Common Lodine Xl and Tylenol drug interactions by age *:








  1. Abdominal pain
  2. Abdominal pain upper
  3. Cholecystitis chronic
  4. Nausea
  5. Vomiting
  6. Abdominal discomfort
  7. Biliary dyskinesia
  8. Cholelithiasis
  9. Cholesterosis
  10. Constipation




  1. Abdominal pain upper
  2. Drug maladministration
  3. Dyspepsia
  4. Fatigue
  5. Myalgia
  6. Overdose
  7. Tongue coated


  1. Upper respiratory tract infection
  2. Urticaria
  3. Pruritus
  4. Adverse event
  5. Angiopathy
  6. Anxiety
  7. Aortic arteriosclerosis
  8. Aortic calcification
  9. Arteriosclerosis
  10. Atelectasis


  1. Abdominal pain upper
  2. Arthralgia
  3. Sweating increased
  4. Tendonitis
  5. Back pain
  6. Burning sensation
  7. Confusion
  8. Drug ineffective
  9. Nausea
  10. Pain in extremity

Common conditions people have *:

  1. Stress And Anxiety: 2 people, 18.18%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
  3. Radicular Pain (pain ""radiated"" along the dermatome (sensory distribution) of a nerve due to inflammation): 1 person, 9.09%
  4. Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 9.09%
  5. Mood Swings (an extreme or rapid change in mood): 1 person, 9.09%
  6. Joint Pain: 1 person, 9.09%
  7. Hormone Level Abnormal: 1 person, 9.09%
  8. Hair Loss: 1 person, 9.09%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%
  10. Back Pain: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Lodine xl and Tylenol?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Browse all drug interactions of Lodine xl and Tylenol:

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Common Tylenol side effects:

Browse all side effects of Tylenol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Tylenol interactions:

Browse all interactions between Tylenol and drugs from A to Z:

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How the study uses the data?

The study uses data from the FDA. It is based on etodolac and acetaminophen (the active ingredients of Lodine xl and Tylenol, respectively), and Lodine xl and Tylenol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Lodine xl and Tylenol.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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