Lyrica and Panadol drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among people who take Lyrica and Panadol. Common interactions include blood thyroid stimulating hormone decreased among females and paraesthesia among males.

The phase IV clinical study analyzes what interactions people who take Lyrica and Panadol have. It is created by eHealthMe based on reports of 42 people who take Lyrica and Panadol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 06, 2023

42 people who take Lyrica and Panadol together, and have interactions are studied.

What is Lyrica?

Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 249,011 Lyrica users for its effectiveness, alternative drugs and more.

What is Panadol?

Panadol has active ingredients of acetaminophen. eHealthMe is studying from 529 Panadol users for its effectiveness, alternative drugs and more.

Number of Lyrica and Panadol reports submitted per year:

Lyrica and Panadol drug interactions.

Common Lyrica and Panadol drug interactions by gender *:


  1. Blood thyroid stimulating hormone decreased
  2. Breast cancer
  3. Burning sensation
  4. Constipation
  5. Decreased appetite
  6. Depression
  7. Diarrhoea
  8. Face injury
  9. Flank pain
  10. Flushing


  1. Paraesthesia
  2. Fall
  3. General physical health deterioration
  4. Joint range of motion decreased
  5. Mobility decreased
  6. Neck pain
  7. Parkinson's disease
  8. Polyneuropathy
  9. Abdominal infection
  10. Asthenia

Common Lyrica and Panadol drug interactions by age *:










  1. Drooling
  2. Hallucination
  3. Overdose
  4. Poisoning
  5. Accommodation disorder
  6. Albumin urine present
  7. Animal bite
  8. Back pain
  9. Basedow's disease
  10. Bile duct obstruction


  1. Abdominal infection
  2. Asthenia
  3. Body mass index increased
  4. Burning sensation
  5. Chorea
  6. Decreased immune responsiveness
  7. Depressed mood
  8. Discomfort
  9. Eating disorder
  10. Fatigue


  1. Cytokine release syndrome
  2. Pyrexia


  1. Fall
  2. Blood creatinine increased
  3. Biliary sepsis
  4. Diarrhoea
  5. Dysgeusia
  6. Erythema
  7. Hypotension
  8. Intestinal perforation
  9. Malignant neoplasm progression
  10. Paraesthesia

Common conditions people have *:

  1. Neuralgia (pain in one or more nerves): 8 people, 19.05%
  2. Back Pain: 8 people, 19.05%
  3. Pain: 7 people, 16.67%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 14.29%
  5. Malignant Melanoma (skin cancer rises from melancytes): 5 people, 11.90%
  6. Constipation: 5 people, 11.90%
  7. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 9.52%
  8. Rashes (redness): 4 people, 9.52%
  9. Pneumonia: 4 people, 9.52%
  10. Multiple Myeloma (cancer of the plasma cells): 4 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Lyrica and Panadol?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

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Alternative drugs to, pros and cons of the 2 drugs:

Browse all drug interactions of Lyrica and Panadol:

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Common Lyrica side effects:

Browse all side effects of Lyrica:

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Common Lyrica interactions:

Browse all interactions between Lyrica and drugs from A to Z:

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How the study uses the data?

The study uses data from the FDA. It is based on pregabalin and acetaminophen (the active ingredients of Lyrica and Panadol, respectively), and Lyrica and Panadol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Lyrica and Panadol.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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