Metformin and Avandia drug interactions - from FDA reports

Summary

Drug interactions are reported among people who take Metformin and Avandia together. This study is created by eHealthMe based on reports of 8,133 people who take Metformin and Avandia from FDA, and is updated regularly.



What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on metformin hydrochloride and rosiglitazone maleate (the active ingredients of Metformin and Avandia, respectively), and Metformin and Avandia (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 259,096 users)

What is Avandia?

Avandia has active ingredients of rosiglitazone maleate. It is often used in diabetes. (latest outcomes from Avandia 141,364 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.


On Feb, 22, 2019

8,133 people who take Metformin, Avandia are studied.


Number of reports submitted per year:

Metformin and Avandia drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Dyspnoea (difficult or laboured respiration)
  2. Cardiac failure congestive
  3. Fatigue (feeling of tiredness)
  4. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  5. Asthenia (weakness)
  6. Weight increased
  7. Blood glucose increased
  8. Diarrhoea
  9. Headache (pain in head)
  10. Cardiovascular disorder (heart diseases)
1 - 6 months:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Cardiac failure congestive
  3. Bladder cancer
  4. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  5. Dyspnoea (difficult or laboured respiration)
  6. Fatigue (feeling of tiredness)
  7. Death
  8. Weight increased
  9. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  10. Blood glucose increased
6 - 12 months:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Cardiac failure congestive
  3. Bladder cancer
  4. Dyspnoea (difficult or laboured respiration)
  5. Weight increased
  6. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  7. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  8. Cardiac disorder
  9. Death
  10. Heart injury
1 - 2 years:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Cardiac failure congestive
  3. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  4. Bladder cancer
  5. Pain
  6. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
  7. Cardiac disorder
  8. Death
  9. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  10. Heart injury
2 - 5 years:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Cardiac failure congestive
  3. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  4. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  5. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
  6. Bladder cancer
  7. Pain
  8. Cardiac disorder
  9. Heart injury
  10. Death
5 - 10 years:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Cardiac failure congestive
  3. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  4. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  5. Cardiac disorder
  6. Pain
  7. Heart injury
  8. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
  9. Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
  10. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
10+ years:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Bladder cancer
  3. Eye disorder
  4. Headache (pain in head)
  5. Hemiplegia (paralysis of one side of the body)
  6. Injury
  7. Memory impairment
  8. Palpitations (feelings or sensations that your heart is pounding or racing)
  9. Abasia (inability to walk)
  10. Apparent death (playing dead)
not specified:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Blood glucose increased
  3. Cardiac failure congestive
  4. Nausea (feeling of having an urge to vomit)
  5. Weight decreased
  6. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  7. Pain
  8. Dyspnoea (difficult or laboured respiration)
  9. Decreased appetite
  10. Weight increased

Most common drug interactions by gender *:

female:
  1. Nausea (feeling of having an urge to vomit)
  2. Weight decreased
  3. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  4. Weight increased
  5. Vomiting
  6. Blood glucose decreased
  7. Dyspnoea (difficult or laboured respiration)
  8. Decreased appetite
  9. Pain
  10. Fatigue (feeling of tiredness)
male:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Cardiac failure congestive
  3. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
  4. Weight increased
  5. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  6. Dizziness
  7. Fatigue (feeling of tiredness)
  8. Injury
  9. Oedema peripheral (superficial swelling)
  10. Anxiety

Most common drug interactions by age *:

0-1:
  1. Abdominal pain
  2. Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
  3. Acute myocardial infarction (acute heart attack)
  4. Arteriosclerosis (thickening and hardening of arteries)
  5. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  6. Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  7. Carotid artery disease
  8. Congenital anomaly (birth defect)
  9. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  10. Foetal growth restriction (poor growth of a baby while in the mother's womb during pregnancy)
2-9:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Angina pectoris (chest pain due to ischemia of the heart muscle)
  3. Anxiety
  4. Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts)
  5. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  6. Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
  7. Pain
  8. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
10-19:
  1. Abdominal discomfort
  2. Bladder cancer
  3. Bone disorder
  4. Decreased appetite
  5. Headache (pain in head)
  6. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
  7. Sudden cardiac death
  8. Weight decreased
  9. Wrist fracture
20-29:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Pain
  3. Weight increased
  4. Cardiac failure congestive
  5. Hypertension (high blood pressure)
  6. Pulmonary embolism (blockage of the main artery of the lung)
  7. Cholecystitis (infection of gallbladder)
  8. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  9. Injury
  10. Obesity (a medical condition in which excess body fat)
30-39:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Cardiac failure congestive
  3. Pain
  4. Blood glucose increased
  5. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  6. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  7. Cardiac disorder
  8. Weight increased
  9. Drug ineffective
  10. Nausea (feeling of having an urge to vomit)
40-49:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Cardiac failure congestive
  3. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  4. Blood glucose increased
  5. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  6. Nausea (feeling of having an urge to vomit)
  7. Pain
  8. Weight decreased
  9. Cardiac disorder
  10. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
50-59:
  1. Blood glucose increased
  2. Nausea (feeling of having an urge to vomit)
  3. Weight decreased
  4. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  5. Pain
  6. Cardiac disorder
  7. Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
  8. Decreased appetite
  9. Vomiting
  10. Fatigue (feeling of tiredness)
60+:
  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Cardiac failure congestive
  3. Pain
  4. Vomiting
  5. Decreased appetite
  6. Fatigue (feeling of tiredness)
  7. Dizziness
  8. Cardiac disorder
  9. Oedema peripheral (superficial swelling)
  10. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and Avandia?


You are not alone:




Related publications that referenced our studies

Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Metformin and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Avandia and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Metformin and Avandia
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Metformin and Avandia



FDA reports used in this study


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