Metformin and Zyban drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin and Zyban. Common interactions include suicidal ideation among females and malaise among males.

The phase IV clinical study analyzes what interactions people who take Metformin and Zyban have. It is created by eHealthMe based on reports of 50 people who take Metformin and Zyban from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Nov, 30, 2022

50 people who take Metformin and Zyban together, and have interactions are studied.


What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 405,986 Metformin users for its effectiveness, alternative drugs and more.

What is Zyban?

Zyban has active ingredients of bupropion hydrochloride. It is often used in quit smoking. eHealthMe is studying from 7,976 Zyban users for its effectiveness, alternative drugs and more.

Number of Metformin and Zyban reports submitted per year:

Metformin and Zyban drug interactions.

Common Metformin and Zyban drug interactions by gender *:

female:

  1. Suicidal ideation
  2. Abdominal discomfort
  3. Abdominal pain lower
  4. Accident
  5. Anxiety
  6. Aphonia
  7. Appetite decreased
  8. Arthritis
  9. Blood glucose decreased
  10. Blood potassium decreased

male:

  1. Malaise
  2. Chest pain
  3. White blood cell count increased
  4. Acidosis
  5. Asthenia
  6. Atrial fibrillation
  7. Blood glucose increased
  8. Cardiac arrest
  9. Cardiac failure congestive
  10. Cardio-respiratory arrest

Common Metformin and Zyban drug interactions by age *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Acute myocardial infarction

40-49:

  1. Malaise
  2. Depressed level of consciousness
  3. Muscle weakness
  4. Sensory loss
  5. Arrhythmia
  6. Blood alcohol increased
  7. Blood cholesterol increased
  8. Cardiac arrest
  9. Chest pain
  10. Confusional state

50-59:

  1. Lactic acidosis
  2. Sinus tachycardia
  3. Agitation
  4. Anxiety
  5. Aphasia
  6. Bladder cancer
  7. Blood bicarbonate decreased
  8. Blood glucose decreased
  9. Blood glucose increased
  10. Blood lactic acid increased

60+:

  1. Malaise
  2. Seizure
  3. Cardio-respiratory arrest
  4. Chronic obstructive pulmonary disease
  5. Dehydration
  6. Dermatitis
  7. Dermatitis exfoliative
  8. Diarrhoea
  9. Diplopia
  10. Dizziness

Common conditions people have *:

  1. Type 2 Diabetes: 4 people, 8.00%
  2. Stress And Anxiety: 4 people, 8.00%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.00%
  4. Cough: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and Zyban?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Browse all drug interactions of Metformin and Zyban:

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Common Metformin side effects:

Browse all side effects of Metformin:

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Common Zyban side effects:

Browse all side effects of Zyban:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Metformin interactions:

Browse all interactions between Metformin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Zyban interactions:

Browse all interactions between Zyban and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride and bupropion hydrochloride (the active ingredients of Metformin and Zyban, respectively), and Metformin and Zyban (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Metformin and Zyban.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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