Metformin and Zyban drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin and Zyban. Common interactions include suicidal ideation among females and malaise among males.

The phase IV clinical study analyzes what interactions people who take Metformin and Zyban have. It is created by eHealthMe based on reports of 50 people who take Metformin and Zyban from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 30, 2022

50 people who take Metformin and Zyban together, and have interactions are studied.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 405,986 Metformin users for its effectiveness, alternative drugs and more.

What is Zyban?

Zyban has active ingredients of bupropion hydrochloride. It is often used in quit smoking. eHealthMe is studying from 7,976 Zyban users for its effectiveness, alternative drugs and more.

Number of Metformin and Zyban reports submitted per year:

Common Metformin and Zyban drug interactions by gender *:

female:

Suicidal ideation
Abdominal discomfort
Abdominal pain lower
Accident
Anxiety
Aphonia
Appetite decreased
Arthritis
Blood glucose decreased
Blood potassium decreased

male:

Malaise
Chest pain
White blood cell count increased
Acidosis
Asthenia
Atrial fibrillation
Blood glucose increased
Cardiac arrest
Cardiac failure congestive
Cardio-respiratory arrest

Common Metformin and Zyban drug interactions by age *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute myocardial infarction

40-49:

Malaise
Depressed level of consciousness
Muscle weakness
Sensory loss
Arrhythmia
Blood alcohol increased
Blood cholesterol increased
Cardiac arrest
Chest pain
Confusional state

50-59:

Lactic acidosis
Sinus tachycardia
Agitation
Anxiety
Aphasia
Bladder cancer
Blood bicarbonate decreased
Blood glucose decreased
Blood glucose increased
Blood lactic acid increased

60+:

Malaise
Seizure
Cardio-respiratory arrest
Chronic obstructive pulmonary disease
Dehydration
Dermatitis
Dermatitis exfoliative
Diarrhoea
Diplopia
Dizziness

Common conditions people have *:

Type 2 Diabetes: 4 people, 8.00%
Stress And Anxiety: 4 people, 8.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.00%
Cough: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and Zyban?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .